本文關(guān)鍵詞：青海地區(qū)藏族慢性乙肝患者血清IP-10的測(cè)定及意義　出處：《青海大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 慢性乙型病毒性肝炎 干擾素誘導(dǎo)蛋白10（IP-10）

【摘要】：目的：探討青海地區(qū)藏族慢性乙型病毒性肝炎（CHB）患者血清中干擾素誘導(dǎo)蛋白10（IP-10）表達(dá)水平、與CHB肝臟損害的關(guān)系及其臨床意義。 方法：選取在青海地區(qū)生活5年以上的藏族、除外母嬰垂直傳播的CHB患者40例，除外CHB以外的肝損傷因素，門診體檢健康者20例。采集空腹靜脈血，分離血清。CHB患者分為輕中度組與重度組，體檢健康者作為對(duì)照組。所有血清樣本用雙抗體夾心ELISA法檢測(cè)干擾素誘導(dǎo)蛋白10（IP-10）表達(dá)水平。采集并記錄CHB患者入院時(shí)血清谷丙轉(zhuǎn)氨酶（ALT）的水平。 結(jié)果：CHB患者（輕中度組及重度組）血清中IP-10水平顯著高于健康組，差異有統(tǒng)計(jì)學(xué)意義（P0.01）。CHB患者血清IP-10水平與肝臟功能損害指標(biāo)（如ALT）呈正相關(guān)關(guān)系（輕中度組r=0.458，P0.05；重度組r=0.647，P0.05）。 結(jié)論：青海地區(qū)藏族慢性乙肝患者中，，IP-10同樣參與了慢性乙肝的損傷過(guò)程；且血清中IP-10的升高水平與肝臟功能損害程度呈正相關(guān)關(guān)系；監(jiān)測(cè)藏族CHB患者血清IP-10的變化,可考慮作為判斷青海藏族CHB患者病情發(fā)展、轉(zhuǎn)歸及指導(dǎo)進(jìn)一步治療的指標(biāo)之一。
[Abstract]:Objective:. To investigate the expression level of interferon inducible protein (IFN- IP-10) in serum of patients with chronic viral hepatitis B (CHB) of Tibetan nationality in Qinghai area and its relationship with liver damage of CHB and its clinical significance. Methods: 40 CHB patients who lived in Qinghai area for more than 5 years except for vertical transmission from mother to child were selected. The factors of liver injury other than CHB were excluded. Fasting venous blood was collected and serum. CHB patients were divided into mild to moderate group and severe group. All serum samples were tested for interferon inducible protein 10 (IP-10) by double antibody sandwich ELISA method. The level of serum alanine aminotransferase (alt) was collected and recorded on admission in patients with CHB. Results the level of IP-10 in the serum of the patients (mild to moderate and severe) was significantly higher than that of the healthy controls. There was a positive correlation between serum IP-10 level and liver function damage (such as alt) in patients with P0.01. CHB (P 0.05). In the severe group, the rhizoid was 0. 647% (P 0. 05). Conclusion: IP-10 is also involved in the damage process of chronic hepatitis B in Tibetan patients in Qinghai area. There was a positive correlation between the level of serum IP-10 and the degree of liver function damage. Monitoring the changes of serum IP-10 in Tibetan CHB patients can be considered as one of the indexes to judge the development of Tibetan CHB in Qinghai province and to guide the further treatment.
【學(xué)位授予單位】：青海大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R512.62

【共引文獻(xiàn)】

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1 王琦;乙肝病毒癌基因HBx與細(xì)胞癌基因RMP的協(xié)同致癌作用及其分子機(jī)制[D];蘇州大學(xué);2013年

2 陸海生;JNK信號(hào)通路介導(dǎo)HBx對(duì)RXRα的磷酸化并促進(jìn)HCC進(jìn)程的分子機(jī)制[D];廈門大學(xué);2014年

本文編號(hào)：1433858