本文關(guān)鍵詞：維生素D受體基因SNP rs2222570多態(tài)性與河南人群肺結(jié)核病易感性研究　出處：《現(xiàn)代預(yù)防醫(yī)學(xué)》2017年13期 　論文類型：期刊論文

  更多相關(guān)文章： 結(jié)核病 維生素D受體基因 基因多態(tài)性 病例-對(duì)照研究

【摘要】：目的調(diào)查河南地區(qū)維生素D受體(VDR)基因SNP位點(diǎn)rs2222570和結(jié)核病易感性之間關(guān)系。方法研究采用以醫(yī)院為基礎(chǔ)的病例對(duì)照研究方法,病例組納入260個(gè)結(jié)核菌菌陽(yáng)患者,并以年齡和性別相匹配納入258名健康體檢人群作為對(duì)照組。采用聚合酶鏈?zhǔn)椒磻?yīng)-限制性片段長(zhǎng)度多態(tài)性對(duì)VDR基因SNP位點(diǎn)rs2222570多態(tài)性進(jìn)行分析。結(jié)果在本次研究中258例對(duì)照人群中VDR基因C/C,C/T和T/T三種基因型分別占110(42.6%),106(41.1%),42(16.3%);在260例結(jié)核病患者中VDR基因C/C,C/T and T/T三種基因型分別占70(26.9%),130(50%),60(23.1%),二者分布存在統(tǒng)計(jì)學(xué)差異(=14.499,P=0.001)。單因素分析表明VDR基因SNP位點(diǎn)rs2222570多態(tài)性與結(jié)核病患病風(fēng)險(xiǎn)相關(guān),VDR基因野生型C/C與雜合型C/T和突變型T/T相比降低了結(jié)核病發(fā)病50%的風(fēng)險(xiǎn)(校正OR=0.496,95%CI:0.344-0.717)。結(jié)論在河南地區(qū)VDR受體基因多態(tài)性與結(jié)核病發(fā)病相關(guān)。
[Abstract]:Objective to investigate the Henan area of the vitamin D receptor (VDR) gene SNP polymorphism and the relationship between the rs2222570 susceptibility of tuberculosis. Methods on a hospital-based case-control study method, case group included 260 TB smear positive patients, and matched by age and gender in 258 healthy subjects as the control group. Using polymerase chain reaction restriction fragment length polymorphism analysis of VDR gene SNP rs2222570 polymorphism. The results in this study, 258 cases of control group in VDR gene C/C, C/T and T/T three genotypes respectively accounted for 110 (42.6%), 106 (41.1%), 42 (16.3%); in 260 cases of TB patients in VDR C/C C/T and T/T gene, three genotypes accounted for 70 (26.9%), 130 (50%), 60 (23.1%), there was a significant difference between the two distributions (=14.499, P=0.001). Single factor analysis showed that the VDR gene SNP rs2222570 polymorphism and tuberculosis The risk of VDR gene wild type C/C is lower than that of heterozygous C/T and mutant T/T. It reduces the risk of TB 50% (corrected OR=0.496,95%CI:0.344-0.717). Conclusion the polymorphism of VDR receptor gene is associated with the incidence of tuberculosis in Henan area.

【作者單位】： 河南省疾病預(yù)防控制中心;
【分類號(hào)】：R181.3;R521
【正文快照】： 據(jù)WTO統(tǒng)計(jì),目前全球感染者約占全球總?cè)丝诘娜种?每天約有8000人死于結(jié)核病,每年約有300萬(wàn)人死于結(jié)核病。中國(guó)作為結(jié)核病高負(fù)擔(dān)國(guó)家,每年有100萬(wàn)人發(fā)病[1]。盡管結(jié)核病作為一種高度傳染性疾病,但結(jié)核菌攜帶者中只有十分之一的發(fā)病,結(jié)核分枝桿菌的感染、結(jié)核病的發(fā)生和轉(zhuǎn)歸

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 石福欣,李國(guó)棟;可溶性白細(xì)胞介素-6受體基因的擴(kuò)增、克隆及序列分析[J];中國(guó)醫(yī)科大學(xué)學(xué)報(bào);1997年04期

2 鐘理;血管緊張素Ⅱ1型受體基因多態(tài)性和二尖瓣脫垂綜合征[J];國(guó)外醫(yī)學(xué).心血管疾病分冊(cè);2000年06期

3 徐家蓉;魯一兵;耿厚法;吳s，

本文編號(hào)：1428300