本文關(guān)鍵詞：體育鍛煉對支持和促進(jìn)干細(xì)胞的自然行為的影響，由筆耕文化傳播整理發(fā)布。

【摘要】：CD34抗原是單鏈跨膜糖蛋白，在造血干細(xì)胞、造血祖細(xì)胞以及內(nèi)皮祖細(xì)胞、內(nèi)皮細(xì)胞、胚胎成纖維細(xì)胞和一些胎兒和成人神經(jīng)組織細(xì)胞表達(dá)。在完全分化的造血干細(xì)胞如淋巴細(xì)胞、單核細(xì)胞、粒細(xì)胞、紅細(xì)胞和血小板不表達(dá)。定期體育運動與低心血管發(fā)病率有關(guān)。然而體育鍛煉有助于心血管疾病發(fā)生的機制目前并不清楚。已有研究表明：體育鍛煉有助于提高和改善內(nèi)皮祖細(xì)胞的數(shù)量和功能。 本研究的目的是評估有氧和無氧運動以及有氧訓(xùn)練和無氧訓(xùn)練對CD34~+細(xì)胞生物學(xué)行為以及后生理參數(shù)的影響。 研究結(jié)果表明： 1有氧運動或有氧訓(xùn)練以及無氧運動或無氧訓(xùn)練均能增加機體最大耗氧量。但以有氧運動或有氧訓(xùn)練增加明顯。 2與無氧運動或無氧訓(xùn)練比，有氧運動或有氧訓(xùn)練顯著降低血液中乳酸含量。 3與有氧運動或有氧訓(xùn)練比，無氧運動或無氧訓(xùn)練顯著增加外周血中血紅蛋白、紅細(xì)胞、白細(xì)胞和紅細(xì)胞容積。 4與對照組或有氧運動、有氧訓(xùn)練比，無氧運動或無氧訓(xùn)練下受試者外周血CD34~+造血祖細(xì)胞的數(shù)量明顯增加。
【關(guān)鍵詞】：
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2013
【分類號】：G804.2
【目錄】：

• Acknowledgments5-7
• 摘要7-8
• Abstract8-12
• List of Tables12-13
• List of Figures13-14
• List of Abbreviations14-16
• INTRODUCTION16-38
• 1.1 EXERCISE TRAINING16-22
• 1.1.1 Development of the body from one egg18-21
• 1.1.2 First Embryonic Stem Cells21
• 1.1.3 Second Adult Stem Cells21-22
• 1.2 WAYS TO OBTAIN STEM CELLS22-24
• 1.2.1 Cell lines are configured for these human cells in one of the following way22-23
• 1.2.2 Way in Which the Thomson and Gearhart to Obtain Embryonic Stem Cells Method of therapeutic cloning23-24
• 1.3 APPLICATIONS AND USES OF STEM CELLS24-26
• 1.3.1 Economic benefit (http://health.dailynewscentral.com)25-26
• 1.4 THE LATEST DEVELOPMENTS IN STEM CELLS26-32
• 1.4.1 Stem cells for the first time to address the patient's heart26-27
• 1.4.2 Production of blood cells from embryonic stem cells27-28
• 1.4.3 Save the cord blood of the newborn in order to play against the treatment of cancer in adulthood28-30
• 1.4.4 Convert adult stem cells to new tissues and Nerves30-31
• 1.4.5 Convert stem cells into nerve cells to treat diseases of the Brain31-32
• 1.5 EMBRYONIC STEM CELLS TO TREAT PARKINSON'S DISEASE32
• 1.6 SPINAL CELLS TO TREAT KIDNEY CANCER32-33
• 1.7 STEM CELLS TO TREAT LIVER PATIENTS33
• 1.8 STEM CELLS TO TREAT DIABETICS33-34
• 1.9 GENETIC ENGINEERING AND STEM CELLS TO TREAT RHEUMATISM AND ARTHRITIS34
• 1.10 DEVISE AN ALTERNATIVE TO EMBRYO CLONING34-35
• 1.11 STEM CELL HISTORY35-38
• REVIEW OF LITERATURE38-52
• 2.1 PHYSICAL ACTIVITY MODES AND FUNCTION39-40
• 2.2 EPCS MARKERS40-41
• 2.3 EXERCISE INDUCED MECHANISMS UNDERLYING VESSEL FORMATION IN MUSCULAR TISSUE41-42
• 2.4 EXERCISE INDUCED STEM CELL MOBILIZATION: ITS THERAPEUTIC OPTION FOR NON-INVASIVE MINIMAL THERAPY42-43
• 2.5 MOBILIZATION IN RESPONSE TO GROWTH FACTORS43-45
• 2.6 HOMING AND SURVIVAL OF EPCS45-46
• 2.7 CIRCADIAN RHYTHMS REGULATE HEMATOPOIESIS46-47
• 2.8 STEM CELL REGULATION47-49
• 2.9 EXTRINSIC REGULATION OF HEMATOPOIETIC STEM CELL49-50
• 2.10 SKELETAL MUSCLE STEM CELLS50-52
• MATERIAL AND METHODS52-62
• 3.1 PARTICIPANTS52
• 3.2 TESTING PROCEDURES52-55
• 3.3 A STRAND -RYHMING TEST55-56
• 3.3.1 Maximal oxygen consumption VO2max (L/min)55-56
• 3.3.2 Circulating progenitor cell number56
• 3.4 IOTEST CD34-PE56-57
• 3.4.1 Use56-57
• 3.4.2 Principle57
• 3.5 EXAMPLES OF CLINICAL57-59
• 3.5.1 Applications57-58
• 3.5.2 Storage and stability58
• 3.5.3 Precautions58-59
• 3.5.4 Samples59
• 3.6 METHODOLOGY59-61
• 3.6.1 Necessary material not supplied59
• 3.6.2 Procedure59-61
• 3.7 BODY COMPOSITION61
• 3.8 STATISTICAL ANALYSIS61-62
• RESULTS62-69
• 4.1 SUBJECTS CHARACTERISTICS62-63
• 4.2 HEMATOPOIETIC STEM CELLS63-69
• DISCUSSION69-82
• 5.1 PHYSIOLOGICAL CHANGES DURING EXERCISE70-78
• 5.2 EPCS AND ADAPTATION RESPONSE78-82
• CONCLUSION82-84
• 6.1 IT MAY BE CONCLUDED THAT82-83
• 6.2 THE QUESTIONS TO BE SOLVED83-84
• References84-98
• Appendix98-130

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  本文關(guān)鍵詞：體育鍛煉對支持和促進(jìn)干細(xì)胞的自然行為的影響，，由筆耕文化傳播整理發(fā)布。

本文編號：362402