廣西白褲瑤聚居地區(qū)不同民族人群心理應(yīng)激狀況及環(huán)境和遺傳影響因素的研究
發(fā)布時間：2018-07-31 08:49
【摘要】：目的(1)了解廣西白褲瑤聚居地區(qū)不同民族人群的心理應(yīng)激及相關(guān)心理行為狀況。(2)探索基因COMT、NPSR1、HSP90B1、HSP90AA2、FKBP5的基因多態(tài)性與廣西白褲瑤聚居地區(qū)的不同民族人群心理應(yīng)激及相關(guān)心理特征的關(guān)系。(3)分析影響廣西白褲瑤聚居地區(qū)的不同民族人群心理應(yīng)激的社會(環(huán)境)與遺傳作用以及之間的關(guān)系。方法(1)采取分層隨機整群抽樣的方法,分別隨機抽取廣西南丹縣白褲瑤族聚集地區(qū)里湖鄉(xiāng)、八圩鄉(xiāng)2個白褲瑤族村以及壯族與漢族雜居地2個村,單純隨機抽取18歲以上的白褲瑤族193人、壯族200人和漢族186人,共579名村民作為研究對象。(2)采用自編一般人口學(xué)、心理應(yīng)激相關(guān)行為因素問卷進行人口學(xué)特征和應(yīng)激相關(guān)行為調(diào)查。(3)對調(diào)查對象進行身高、體重、腰圍、臀圍、腹圍、心率、血壓等體格檢查和TC、TG、HDLC和LDLC生化指標(biāo)檢測。(4)采用心理測量工具生活事件量表、簡化心身癥狀自評量表、簡易應(yīng)對方式問卷、社會支持評定量表調(diào)查心理應(yīng)激及相關(guān)心理特征。(5)采用iMLDR法對COMT基因的rs6267、rs769224、rs4680、NPSR1基因的rs12673132、rs6947841、rs324981、rs6972158,HSP90B1基因的rs17034977,HSP90AA2基因的rs2726836以及FKBP5基因的rs1360780、 rs3800373共11個位點SNP分型檢測。(6)采用SPSS19.0統(tǒng)計軟件、Amos5.0統(tǒng)計分析軟件進行數(shù)據(jù)分析。應(yīng)用t檢驗或卡方檢驗比較不同人口學(xué)特征之間應(yīng)激相關(guān)的心理行為和基因型、等位基因的分布。應(yīng)用Amos5.0構(gòu)建結(jié)構(gòu)方程,分析(社會)環(huán)境與心理應(yīng)激發(fā)生的關(guān)系。通過單因素和多因素logistic回歸分析(社會)環(huán)境因素、基因多態(tài)性與心理應(yīng)激發(fā)生風(fēng)險的關(guān)系。結(jié)果(1)總體生活事件量表得分第百分五十分位數(shù)(P50)是27分,總分≥20分的有293人次,陽性率50.60%。其中,家庭事件、工作事件和社交事件的發(fā)生頻率分別為75.82%、11.57%和24.35%。發(fā)生頻率排在前三位的生活事件分別是家庭經(jīng)濟困難234,人次(40.41%)、欠債133人次(22.97%)、住房緊張96人次(16.58%)。(2)總體心理癥狀總分44.39±13.16,范圍是29-110,總體陽性率13.82%。四個因子均分分別是軀體化1.75±0.63、焦慮1.47±0.58、抑郁1.51±0.58、敵對1.32±0.45；三個民族的心理因子的陽性率在8.00%-34.48%之間。焦慮因子在三個民族和總體之間差異有統(tǒng)計學(xué)意義(P0.05)；與全國常模比較,三個民族的軀體化因子均高于常模,白褲瑤族的焦慮高于全國常模,敵對低于常模；壯族的敵對因子低于全國常模。(3)總體應(yīng)對方式總分40.93±10.95,其中積極應(yīng)對為25.61±8.10；消極應(yīng)對為15.32±4.39。漢族的積極應(yīng)對分最高,壯族其次,白褲瑤族最低。三個民族消極應(yīng)對、積極應(yīng)對均高于全國常模。(4)總體社會支持總分27.72±6.07；其中主觀支持為12.57±3.09；客觀支持為8.24±2.60；支持利用度為6.91±2.42,漢族的主觀支持高于壯族。與壯族常模比較,三個民族的社會支持總分、主觀支持和社會支持利用度均小于常模；客觀支持則高于常模。(5)篩查的5個基因的11個基因位點的基因型和等位基因分布情況,NPSRlrs12673132位點的等位基因G/A,NPSR1rs6947841的等位基因C/T在性別之間差異有統(tǒng)計學(xué)意義(P0.05)。對不同民族的基因型和基因分布情況進行比較,除了NPSRlrs324981的基因型和等位基因、HSP90BIrs17034977和HSP90AA2rs2726836的等位基因在三個民族之間差異無統(tǒng)計學(xué)意義外(P0.05),其他基因位點的基因型和基因位點在三個民族之間差異均有統(tǒng)計學(xué)意義(P0.05)。(6)以生活事件總分≥20分為心理應(yīng)激陽性,對篩查基因位點的生活事件陽性/陰性分組的基因型和等位基因分布進行比較,白褲瑤族、漢族人群未發(fā)現(xiàn)兩組之間差異；壯族人群COMTrs4680的基因型；NPSRlrs324981的基因型和等位基因,FKBP5rs1360780的基因型分別在兩組差異有統(tǒng)計學(xué)意義(P0.05)。(7)以心理癥狀因子分≥2分為心理癥狀陽性,對篩查基因位點的心理癥狀陽性/陰性分組的基因型和等位基因分布進行比較,白褲瑤族人群的焦慮因子兩組比較中發(fā)現(xiàn)FKBP5rs1360780和FKBP5rs3800373的基因型和等位基因分布差異有統(tǒng)計學(xué)意義(P0.05)。在壯族人群中,COMTrs769224、NPSR1rs6947841、NPSR1rs6972158位點的基因型在焦慮因子兩組間差異有統(tǒng)計學(xué)意義(P0.05)；FKBP5rs1360780的等位基因在抑郁因子兩組間差異有統(tǒng)計學(xué)意義(P0.05)。對漢族人群的HSP90AA2rs2726836等位基因在軀體化因子兩組問差異有統(tǒng)計學(xué)意義(P0.05)。NPSR1rs324981的等位基因在抑郁因子兩組間差異有統(tǒng)計學(xué)意義(P0.05)。COMTrs769224的基因型和等位基因、HSP90AA2rs2726836的等位基因在敵對因子兩組間差異有統(tǒng)計學(xué)意義(P0.05)。(8)對不同應(yīng)對方式分組的基因型和等位基因進行比較,漢族的NPSR1rs6972158等位基因分布差異有統(tǒng)計學(xué)意義(P0.05)。利用多元方差模型分析,對白褲瑤族、壯族和漢族的篩查基因位點的主觀支持、客觀支持和支持利用度進行比較,三個維度之間差異無統(tǒng)計學(xué)意義(P0.05)。(9)應(yīng)用單因素Logistic回歸分析全體調(diào)查對象不同基因型與心理應(yīng)激(生活事件陽性)發(fā)生的危險性,結(jié)果發(fā)現(xiàn)以NPSRl基因rs324981位點AA基因型為參照,攜帶TT基因型者發(fā)生心理應(yīng)激的風(fēng)險降低0.445(95%CI：0.234-0.844)倍,差異有統(tǒng)計學(xué)意義(P0.05)。(10)應(yīng)用多因素Logistic回歸分析結(jié)果顯示,軀體化、焦慮和抑郁三個心理癥狀使心理應(yīng)激發(fā)生風(fēng)險分別增加2.381倍(95%CI:1.554-3.649),2.017倍(95%CI：1.148-3.544)和1.845倍(95%CI：1.053-3.230),差異均有統(tǒng)計學(xué)意義(P0.05)。舒張壓和收縮壓使心理應(yīng)激發(fā)生風(fēng)險分別為0.981倍(95%CI:0.968-0.995)和1.025倍(95%CI：1.003-1.048),差異均有統(tǒng)計學(xué)意義(P0.05)。結(jié)論(1)廣西白褲瑤族聚居地區(qū)人群總體生活事件陽性率較高,引起心理應(yīng)激的事件以家庭事件為主。(2)研究對象總體心理癥狀陽性率處在正常范圍,焦慮水平在三個民族之間具有差異；三個民族的軀體化以及白褲瑤族的焦慮程度較全國平均水平高,兩少數(shù)民族的敵對程度均低于平均水平。三個民族消極應(yīng)對、積極應(yīng)對均高于全國水平,漢族的積極應(yīng)對最多見。三個民族的社會支持總分、主觀支持和社會支持利用度低于壯族平均水平；客觀支持則較高。(3)NPSRlrs12673132、rs6947841基因位點的基因型或等位基因存在性別差異。COMTrs6267、rs769224、rs4680, NPSR1rs12673132、rs324981、 rs6972158以及FKBP5rsl360780、rs3800373基因位點的基因型或等位基因存在民族差異。(4)篩查選取的FKBP5 rs1360780、rs3800373,C0MT rs4680.769224, NPSR1 rs324981、rs6947841、rs6972158, HSP90AA2rs2726836基因位點多態(tài)性分布在不同民族的生活事件、心理癥狀、應(yīng)對方式中體現(xiàn)出差異。(5) NPSR1rs324981基因位點攜帶T等位基因的基因型可能是心理應(yīng)激發(fā)生的保護性基因型。軀體化、焦慮和抑郁心理癥狀和收縮壓升高是心理應(yīng)激發(fā)生的危險因素；舒張壓降低是心理應(yīng)激發(fā)生的保護因素。
[Abstract]:Objective (1) to understand the psychological stress and related psychological behavior of different ethnic groups in the habitation area of Guangxi Bai Ku Yao. (2) explore the genetic polymorphisms of gene COMT, NPSR1, HSP90B1, HSP90AA2, FKBP5 and the psychological stress and psychological characteristics of different ethnic groups in the habitation area of Guangxi Bai Ku Yao. (3) analysis of the influence of Guangxi Bai Ku Yao settlement The relationship between the social (environment) and the heredity and the relationship between the psychological stress of different ethnic groups in the region. Method (1) the method of stratified random cluster sampling was adopted to randomly select the Guangxi Nandan County white trousers and Yao Nationality Area Li Hu Township, the 2 white trousers and Yao Ethnic Villages in eight polder villages and the 2 villages of the Zhuang and Han Hans, which were randomly selected for 18 years of age. 193 people of Bai Ku Yao, 200 Zhuang and 186 Han people, 579 villagers were studied as subjects. (2) a survey of demographic characteristics and stress related behavior was conducted by self-made general demography and psychological stress related behavioral factors questionnaire. (3) body height, weight, waist circumference, hip circumference, heart rate, blood pressure, and other physical examinations and TC, TG, HDLC and LDLC biochemical indexes. (4) the psychometric tool life events scale was used to simplify the self rating scale of psychosomatic symptoms, simple coping style questionnaire, and social support rating scale to investigate psychological stress and related psychological characteristics. (5) rs6267, rs769224, rs4680, rs12673132, rs6947841, rs324981, COMT gene, rs6267, rs769224, rs4680, and the iMLDR method were used. Rs6972158, HSP90B1 gene rs17034977, HSP90AA2 gene rs2726836 and FKBP5 gene rs1360780, rs3800373 altogether 11 loci SNP typing. (6) SPSS19.0 statistical software, Amos5.0 statistical analysis software for data analysis. Using t test or chi square test to compare the stress related psychological behavior between different demographic characteristics and the difference between the psychological behavior and the The distribution of genotypes and alleles. Structure equations were constructed with Amos5.0, and the relationship between (SOCIAL) environment and psychological stress was analyzed. The relationship between genetic polymorphism and the risk of psychological stress was analyzed by single factor and multiple factor Logistic regression analysis (SOCIAL). Results (1) the score of the total life event scale was fifty. P50) was 27. There were 293 people with a total score of more than 20. The positive rate was 50.60%.. The frequency of family events, work events and social events were 75.82%, 11.57% and 24.35%., respectively, were 234, 40.41%, 22.97%, 96 (16.58%). (16.58%). (2) The total score of the total psychological symptoms was 44.39 + 13.16, with a range of 29-110. The total positive rate of 13.82%. four factors was 1.75 + 0.63, anxiety 1.47 + 0.58, depression 1.51 + 0.58 and hostile 1.32 0.45, and the positive rate of psychological factors of three nationalities was between 8.00%-34.48%. P0.05, compared with the national norm, the somatization factors of the three ethnic groups were all higher than the norm, and the anxiety of the Bai Ku Yao was higher than the national norm and the enemy was lower than the norm. The antagonism factor of the Zhuang nationality was lower than the national norm. (3) the total coping style was 40.93 + 10.95, of which the positive should be 25.61 + 8.10, and the negative coping was 15.32 + 4.39. Han Han. Coping with the highest score, the second of Zhuang nationality, white pants Yao was the lowest. Three ethnic negative responses were higher than the national norm. (4) the total social support score was 27.72 + 6.07, the subjective support was 12.57 + 3.09, the objective support was 8.24 + 2.60, the support utilization was 6.91 + 2.42, and the subjective support of the Han nationality was higher than the Zhuang. Compared with the Zhuang normal model, three. The subjective support and social support utilization are less than the norm, and the objective support is higher than the norm. (5) the genotype and allele distribution of the 11 gene loci of the 5 genes of the screening, the allele G/A of the NPSRlrs12673132 site and the NPSR1rs6947841 allele C/T are statistically different among the sexes. Study significance (P0.05). Compared with the genotype and gene distribution of different nationalities, the alleles of HSP90BIrs17034977 and HSP90AA2rs2726836 are not statistically significant between the three ethnic groups except the genotype and allele of NPSRlrs324981 (P0.05), and the genotypes and loci of the other gene loci are between the three nationalities. The difference was statistically significant (P0.05). (6) the total score of the life events was more than 20, and the genotype and allele distribution of the positive / negative group were compared. The white pants Yao nationality, the Han population did not find the difference between the two groups; the COMTrs4680 genotypes of the Zhuang population; NPSRlrs324981 Genotypes and alleles, the genotypes of FKBP5rs1360780 were statistically significant in the two groups (P0.05). (7) the psychological symptom factor was more than 2 of the mental symptoms positive, and the genotype and allele distribution of the positive / negative group of the screening gene locus were compared, and the two groups of anxiety factors of the Bai pants Yao population were compared. There was significant difference in the distribution of genotypes and alleles between FKBP5rs1360780 and FKBP5rs3800373 (P0.05). In the Zhuang population, the genotype of COMTrs769224, NPSR1rs6947841 and NPSR1rs6972158 loci were statistically significant between the two groups of anxiety factors (P0.05); FKBP5rs1360780 alleles were among the two groups of depressive factors. The difference was statistically significant (P0.05). The HSP90AA2rs2726836 alleles of the Han population were statistically significant in the two groups of somatization factors (P0.05).NPSR1rs324981 alleles were statistically significant in the two groups of depressive factors (P0.05).COMTrs769224 genotypes and alleles, HSP90AA2rs2726836 alleles were in a statistical significance The differences between the two groups were statistically significant (P0.05). (8) the genotype and alleles of different coping styles were compared, and the distribution of NPSR1rs6972158 alleles in the Han nationality was statistically significant (P0.05). The subjective support of the screening gene loci of Bai Ku Yao nationality, Zhuang and Han nationality was analyzed by multivariate variance model. The difference between the three dimensions was not statistically significant (P0.05). (9) a single factor Logistic regression was used to analyze the risk of different genotypes and psychological stress (positive life events) in all the subjects, and the results were found to carry the TT genotype in the NPSRl based rs324981 locus AA genotype. The risk of psychological stress decreased by 0.445 (95%CI:0.234-0.844), and the difference was statistically significant (P0.05). (10) the results of multiple factor Logistic regression analysis showed that the three psychological symptoms of somatization, anxiety and depression increased the risk of psychological stress by 2.381 times (95%CI:1.554-3.649), 2.017 times (95%CI:1.148-3.544) and 1.845 times (95%C). I:1.053-3.230), the difference was statistically significant (P0.05). The risk of diastolic and systolic pressure was 0.981 times (95%CI:0.968-0.995) and 1.025 times (95%CI:1.003-1.048) respectively. The difference was statistically significant (P0.05). Conclusion (1) the positive rate of overall life events in the population of Guangxi Bai Ku Yao people was higher, causing psychological stress. The most exciting events are family events. (2) the positive rate of the overall psychological symptoms of the study is in the normal range, and the level of anxiety is different among the three ethnic groups; the somatization of the three ethnic groups and the anxiety of the Bai Ku Yao are higher than the national average, and the enemy pairs of the two ethnic minorities are lower than the average level. Three ethnic groups should be negative. The positive response was higher than the national level. The positive response of the Han people was the most common. The total social support score of the three ethnic groups, the subjective support and the social support utilization were lower than the average level of the Zhuang, and the objective support was higher. (3) NPSRlrs12673132, the genotype or allele of the rs6947841 gene locus had sex differences.COMTrs6267, rs769224, rs468. 0, NPSR1rs12673132, rs324981, rs6972158, and FKBP5rsl360780, there are ethnic differences in genotype or allele of rs3800373 gene loci. (4) screening selected FKBP5 rs1360780, rs3800373, C0MT rs4680.769224, NPSR1 rs324981, polymorphism distribution in different ethnic groups. Differences in psychological symptoms and coping styles. (5) the genotype of NPSR1rs324981 allele carrying T allele may be a protective genotype of psychological stress. Somatization, anxiety and depression and elevated systolic pressure are the risk factors for psychological stress; diastolic pressure is a protective cause of psychological stress. Prime.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2015
【分類號】：B844;R195
本文編號：2155060
[Abstract]:Objective (1) to understand the psychological stress and related psychological behavior of different ethnic groups in the habitation area of Guangxi Bai Ku Yao. (2) explore the genetic polymorphisms of gene COMT, NPSR1, HSP90B1, HSP90AA2, FKBP5 and the psychological stress and psychological characteristics of different ethnic groups in the habitation area of Guangxi Bai Ku Yao. (3) analysis of the influence of Guangxi Bai Ku Yao settlement The relationship between the social (environment) and the heredity and the relationship between the psychological stress of different ethnic groups in the region. Method (1) the method of stratified random cluster sampling was adopted to randomly select the Guangxi Nandan County white trousers and Yao Nationality Area Li Hu Township, the 2 white trousers and Yao Ethnic Villages in eight polder villages and the 2 villages of the Zhuang and Han Hans, which were randomly selected for 18 years of age. 193 people of Bai Ku Yao, 200 Zhuang and 186 Han people, 579 villagers were studied as subjects. (2) a survey of demographic characteristics and stress related behavior was conducted by self-made general demography and psychological stress related behavioral factors questionnaire. (3) body height, weight, waist circumference, hip circumference, heart rate, blood pressure, and other physical examinations and TC, TG, HDLC and LDLC biochemical indexes. (4) the psychometric tool life events scale was used to simplify the self rating scale of psychosomatic symptoms, simple coping style questionnaire, and social support rating scale to investigate psychological stress and related psychological characteristics. (5) rs6267, rs769224, rs4680, rs12673132, rs6947841, rs324981, COMT gene, rs6267, rs769224, rs4680, and the iMLDR method were used. Rs6972158, HSP90B1 gene rs17034977, HSP90AA2 gene rs2726836 and FKBP5 gene rs1360780, rs3800373 altogether 11 loci SNP typing. (6) SPSS19.0 statistical software, Amos5.0 statistical analysis software for data analysis. Using t test or chi square test to compare the stress related psychological behavior between different demographic characteristics and the difference between the psychological behavior and the The distribution of genotypes and alleles. Structure equations were constructed with Amos5.0, and the relationship between (SOCIAL) environment and psychological stress was analyzed. The relationship between genetic polymorphism and the risk of psychological stress was analyzed by single factor and multiple factor Logistic regression analysis (SOCIAL). Results (1) the score of the total life event scale was fifty. P50) was 27. There were 293 people with a total score of more than 20. The positive rate was 50.60%.. The frequency of family events, work events and social events were 75.82%, 11.57% and 24.35%., respectively, were 234, 40.41%, 22.97%, 96 (16.58%). (16.58%). (2) The total score of the total psychological symptoms was 44.39 + 13.16, with a range of 29-110. The total positive rate of 13.82%. four factors was 1.75 + 0.63, anxiety 1.47 + 0.58, depression 1.51 + 0.58 and hostile 1.32 0.45, and the positive rate of psychological factors of three nationalities was between 8.00%-34.48%. P0.05, compared with the national norm, the somatization factors of the three ethnic groups were all higher than the norm, and the anxiety of the Bai Ku Yao was higher than the national norm and the enemy was lower than the norm. The antagonism factor of the Zhuang nationality was lower than the national norm. (3) the total coping style was 40.93 + 10.95, of which the positive should be 25.61 + 8.10, and the negative coping was 15.32 + 4.39. Han Han. Coping with the highest score, the second of Zhuang nationality, white pants Yao was the lowest. Three ethnic negative responses were higher than the national norm. (4) the total social support score was 27.72 + 6.07, the subjective support was 12.57 + 3.09, the objective support was 8.24 + 2.60, the support utilization was 6.91 + 2.42, and the subjective support of the Han nationality was higher than the Zhuang. Compared with the Zhuang normal model, three. The subjective support and social support utilization are less than the norm, and the objective support is higher than the norm. (5) the genotype and allele distribution of the 11 gene loci of the 5 genes of the screening, the allele G/A of the NPSRlrs12673132 site and the NPSR1rs6947841 allele C/T are statistically different among the sexes. Study significance (P0.05). Compared with the genotype and gene distribution of different nationalities, the alleles of HSP90BIrs17034977 and HSP90AA2rs2726836 are not statistically significant between the three ethnic groups except the genotype and allele of NPSRlrs324981 (P0.05), and the genotypes and loci of the other gene loci are between the three nationalities. The difference was statistically significant (P0.05). (6) the total score of the life events was more than 20, and the genotype and allele distribution of the positive / negative group were compared. The white pants Yao nationality, the Han population did not find the difference between the two groups; the COMTrs4680 genotypes of the Zhuang population; NPSRlrs324981 Genotypes and alleles, the genotypes of FKBP5rs1360780 were statistically significant in the two groups (P0.05). (7) the psychological symptom factor was more than 2 of the mental symptoms positive, and the genotype and allele distribution of the positive / negative group of the screening gene locus were compared, and the two groups of anxiety factors of the Bai pants Yao population were compared. There was significant difference in the distribution of genotypes and alleles between FKBP5rs1360780 and FKBP5rs3800373 (P0.05). In the Zhuang population, the genotype of COMTrs769224, NPSR1rs6947841 and NPSR1rs6972158 loci were statistically significant between the two groups of anxiety factors (P0.05); FKBP5rs1360780 alleles were among the two groups of depressive factors. The difference was statistically significant (P0.05). The HSP90AA2rs2726836 alleles of the Han population were statistically significant in the two groups of somatization factors (P0.05).NPSR1rs324981 alleles were statistically significant in the two groups of depressive factors (P0.05).COMTrs769224 genotypes and alleles, HSP90AA2rs2726836 alleles were in a statistical significance The differences between the two groups were statistically significant (P0.05). (8) the genotype and alleles of different coping styles were compared, and the distribution of NPSR1rs6972158 alleles in the Han nationality was statistically significant (P0.05). The subjective support of the screening gene loci of Bai Ku Yao nationality, Zhuang and Han nationality was analyzed by multivariate variance model. The difference between the three dimensions was not statistically significant (P0.05). (9) a single factor Logistic regression was used to analyze the risk of different genotypes and psychological stress (positive life events) in all the subjects, and the results were found to carry the TT genotype in the NPSRl based rs324981 locus AA genotype. The risk of psychological stress decreased by 0.445 (95%CI:0.234-0.844), and the difference was statistically significant (P0.05). (10) the results of multiple factor Logistic regression analysis showed that the three psychological symptoms of somatization, anxiety and depression increased the risk of psychological stress by 2.381 times (95%CI:1.554-3.649), 2.017 times (95%CI:1.148-3.544) and 1.845 times (95%C). I:1.053-3.230), the difference was statistically significant (P0.05). The risk of diastolic and systolic pressure was 0.981 times (95%CI:0.968-0.995) and 1.025 times (95%CI:1.003-1.048) respectively. The difference was statistically significant (P0.05). Conclusion (1) the positive rate of overall life events in the population of Guangxi Bai Ku Yao people was higher, causing psychological stress. The most exciting events are family events. (2) the positive rate of the overall psychological symptoms of the study is in the normal range, and the level of anxiety is different among the three ethnic groups; the somatization of the three ethnic groups and the anxiety of the Bai Ku Yao are higher than the national average, and the enemy pairs of the two ethnic minorities are lower than the average level. Three ethnic groups should be negative. The positive response was higher than the national level. The positive response of the Han people was the most common. The total social support score of the three ethnic groups, the subjective support and the social support utilization were lower than the average level of the Zhuang, and the objective support was higher. (3) NPSRlrs12673132, the genotype or allele of the rs6947841 gene locus had sex differences.COMTrs6267, rs769224, rs468. 0, NPSR1rs12673132, rs324981, rs6972158, and FKBP5rsl360780, there are ethnic differences in genotype or allele of rs3800373 gene loci. (4) screening selected FKBP5 rs1360780, rs3800373, C0MT rs4680.769224, NPSR1 rs324981, polymorphism distribution in different ethnic groups. Differences in psychological symptoms and coping styles. (5) the genotype of NPSR1rs324981 allele carrying T allele may be a protective genotype of psychological stress. Somatization, anxiety and depression and elevated systolic pressure are the risk factors for psychological stress; diastolic pressure is a protective cause of psychological stress. Prime.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2015
【分類號】：B844;R195
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