本文關(guān)鍵詞：腦動脈瘤血管支架的結(jié)構(gòu)設(shè)計(jì)及其血流場分析　出處：《新疆大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 腦動脈瘤 血管支架結(jié)構(gòu) 血流場特性 雙向流固耦合

【摘要】：背景腦動脈瘤是人體腦部的血管不正常的突起或者血管的增大膨脹,加之長期以往血流沖擊形成血塊,引起血管狹窄、腦部供血不足或者腦部血管破裂最后死亡的疾病�，F(xiàn)代醫(yī)學(xué)中臨床主要的治療手段是手術(shù)治療,但存在著很大風(fēng)險(xiǎn),因此提出了支架治療動脈瘤的方法。目的研究支架的植入與血流場的作用機(jī)理以及不同變量條件對支架植入后血流場的變化情況,來判斷支架結(jié)構(gòu)設(shè)計(jì)的合理性,為進(jìn)一步探究植入支架后的動脈瘤的動力學(xué)參數(shù)與動脈瘤再狹窄、破裂之間的關(guān)系。方法根據(jù)臨床病人的CT數(shù)據(jù),采用MIMICS軟件建立腦動脈瘤的切片模型。表面模型用逆向工程軟件進(jìn)行優(yōu)化處理,再經(jīng)過三角模型的NURBS優(yōu)化處理,結(jié)果個(gè)體化腦動脈瘤模型的建立;然后,根據(jù)動脈瘤形狀及尺寸,通過UG設(shè)計(jì)了三種血管支架的模型(C型、G型、H型),接下來分析模型的特征,包括血管支架的柔順性、血管支架的徑向支撐力、血管支架的表面覆蓋率分析及血管支架的疲勞壽命分析;最后,將設(shè)計(jì)好的三種支架裝配到構(gòu)建的動脈瘤模型,采用雙向流固耦合的方法對裝配模型進(jìn)行了血流場特性分析,包括血流速度變化、血流壓力變化、壁面剪切力變化及壁面變形情況等。結(jié)果與結(jié)論通過ANSYS模擬仿真最終得到了支架的柔順性分析圖、支架的支撐力分析圖、支架的壽命圖、支架的表面覆蓋率分析圖,對三種支架特性進(jìn)行綜合評價(jià),得出H型支架優(yōu)于其他兩種支架(良好的柔順性、較強(qiáng)的徑向支撐力、持久的抵抗疲勞強(qiáng)度及較大的表面覆蓋率);其次進(jìn)行支架植入后得到血流場的血流速度圖、血流壓力圖、血流壁面剪切力圖、壁面變形分析圖。得出了在一個(gè)心動周期0-0.8s內(nèi),四個(gè)典型時(shí)刻即0.05s、0.09s、0.26s、0.32s的流速、壁面切應(yīng)力、壁面壓力均減小了;三種支架分別在0.09s、0.32s時(shí)刻壁面切應(yīng)力減小程度依次是G型、C型、H型;H型支架壁面剪切力在0.34s時(shí)刻減小最小;三種支架的壓力中C型支架的壓力范圍在398-407Pa之間,壓力變形最小在血流入口處;最后用10位患者統(tǒng)計(jì)數(shù)據(jù)進(jìn)行數(shù)據(jù)驗(yàn)證,得出文章方法的可行性。
[Abstract]:Background Cerebral aneurysms are abnormal processes of blood vessels or dilation of blood vessels in the human brain, combined with blood clots formed by blood flow impact for a long time, resulting in stenosis of blood vessels. A disease in which insufficient blood supply to the brain or the eventual death of a ruptured blood vessel in the brain. Surgical treatment is the main clinical treatment in modern medicine, but there are significant risks. Objective to study the mechanism of stent implantation and blood flow field and the changes of blood flow field after stent implantation under different variable conditions. To determine the rationality of stent structure design, in order to further explore the relationship between the dynamic parameters and restenosis and rupture of the aneurysm after stent implantation. Methods according to the CT data of clinical patients. The slice model of cerebral aneurysm was established by MIMICS software. The surface model was optimized by reverse engineering software and then optimized by NURBS of triangle model. Results the individualized cerebral aneurysm model was established. Then, according to the shape and size of aneurysm, three kinds of angiostents were designed by UG. Then, the characteristics of the model, including the flexibility of the stent, were analyzed. The radial supporting force of vascular stent, the surface coverage of vascular stent and the fatigue life of vascular stent were analyzed. Finally, three kinds of scaffolds were assembled into the aneurysm model, and the characteristics of blood flow field were analyzed by two-way fluid-solid coupling method, including the changes of blood flow velocity and blood pressure. Results and conclusions the ANSYS simulation results and conclusions the support analysis diagram, support force analysis diagram and life diagram of the support are obtained by ANSYS simulation. Analysis of the surface coverage of the scaffold, comprehensive evaluation of the characteristics of the three scaffolds, it is concluded that the H-type bracket is superior to the other two kinds of scaffolds (good flexibility, strong radial support. Durable fatigue resistance and greater surface coverage; Secondly, the blood flow velocity map, blood pressure map, wall shear force and wall deformation analysis were obtained after stent implantation. The results were obtained within 0-0.8 s of a cardiac cycle. The shear stress and pressure of the wall are all reduced at the flow rate of 0.05s0. 09s / 0. 26s / 0.32s at four typical times. At 0.09s / 0.32s, the shear stress of the three kinds of scaffolds is G / C / H respectively. The shear force on the wall of the H-type bracket decreases to a minimum at 0.34 s. The pressure range of C type stent is between 398-407 Pa and the pressure deformation is minimum at the entrance of blood flow. Finally, 10 patients with statistical data were used to verify the data, and the feasibility of the method was obtained.
【學(xué)位授予單位】：新疆大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R743;R318.08

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