【摘要】：[目的]檢測(cè)CD44基因在腸息肉和結(jié)直腸癌中的表達(dá),探討其對(duì)結(jié)直腸腫瘤癌變的臨床意義。[方法]采用Real-time PCR方法檢測(cè)CD44在82例結(jié)直腸增生型炎性息肉、腺瘤性息肉和癌變息肉組織中的表達(dá)。[結(jié)果]增生型炎性息肉組織中CD44 mRNA相對(duì)表達(dá)量為0.0006±0.0001,腺瘤性息肉組織中為0.0019±0.0006,癌變息肉組織中為0.0073±0.0016,三組相比,P均0.05。有淋巴結(jié)轉(zhuǎn)移者與無(wú)淋巴結(jié)轉(zhuǎn)移者腫瘤組織中CD44 mRNA表達(dá)量相比,P0.05;TNM分期Ⅲ+Ⅳ者與Ⅰ+Ⅱ者腫瘤組織中CD44 mRNA表達(dá)量相比,P0.05。相關(guān)性分析結(jié)果顯示,CD44的表達(dá)強(qiáng)度與腸息肉癌變進(jìn)展呈正相關(guān)(r=0.562,P0.0001)。[結(jié)論]CD44基因在結(jié)腸癌組織中表達(dá)異常升高,提示CD44可能與結(jié)腸癌的發(fā)生、發(fā)展有密切關(guān)系。
[Abstract]:[objective] to detect the expression of CD44 gene in colorectal polyps and colorectal cancer, and to explore its clinical significance in colorectal cancer. [methods] the expression of CD44 in 82 cases of colorectal hyperplasia inflammatory polyp, adenomatous polyp and canceration polyp was detected by Real-time PCR method. [results] the relative expression of CD44 mRNA was 0.0006 鹵0.0001 in proliferative inflammatory polyps, 0.0019 鹵0.0006 in adenomatous polyps and 0.0073 鹵0.0016 in cancerous polyps (P < 0.05). The expression of CD44 mRNA in the tumor tissues with and without lymph node metastasis was higher than that in the tumor tissues with and without lymph node metastasis, and the expression of CD44 mRNA in the patients with P0.05TNM stage 鈪，

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