本文選題：類風(fēng)濕關(guān)節(jié)炎 + 白介素F�。� 參考：《中國免疫學(xué)雜志》2017年08期

【摘要】：目的:探討白介素17F(IL-17F)基因多態(tài)性rs763780和rs2397084與類風(fēng)濕關(guān)節(jié)炎(RA)易感性的關(guān)系。方法:計(jì)算機(jī)檢索中國學(xué)術(shù)期刊全文數(shù)據(jù)庫、萬方數(shù)據(jù)庫、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫、Pubmed、Embase以及Web of Science中已發(fā)表的與RA和IL-17F基因多態(tài)性相關(guān)文獻(xiàn),進(jìn)行Meta分析。結(jié)果:納入的5項(xiàng)研究共收集RA患者1 174例(其中rs763780含1 174例,rs2397084含985例),正常對(duì)照966例(rs763780含966例,rs2397084含766例)。Meta分析結(jié)果顯示,rs763780與RA密切相關(guān)(C vs.T:OR=1.74,95%CI=1.01-2.98,P=0.04;CC vs.TT:OR=3.17,95%CI=1.21-8.35,P=0.02;CT vs.TT:OR=1.80,95%CI=1.21-2.66,P=0.004;CC+CT vs.TT:OR=1.96,95%CI=1.35-2.83,P0.001;CC vs.CT+TT:OR=2.97,95%CI=1.13-2.66,P=0.03)。根據(jù)人種進(jìn)行亞組分析發(fā)現(xiàn),在歐洲人群中rs763780與RA密切相關(guān),差異具有統(tǒng)計(jì)學(xué)意義。未發(fā)現(xiàn)rs2397084與RA之間的相關(guān)性。結(jié)論:IL-17F rs763780是RA的危險(xiǎn)因素,IL-17F rs2397084與RA易感性是否有關(guān)仍不明確。
[Abstract]:Objective: to investigate the association of interleukin 17 F (IL 17 F) gene polymorphism rs763780 and rs2397084 with rheumatoid arthritis (RA). Methods: the full text database of Chinese academic journals, Wanfang database, Chinese biomedical literature database, Pubmedmedan Embase and the published literatures related to RA and IL-17F gene polymorphisms in Web of Science were searched by computer and analyzed by meta-analysis. 緇撴灉:綰沖叆鐨，

本文編號(hào)：2060015