本文選題：CLOCK + 原發(fā)性男性不育�。� 參考：《中國公共衛(wèi)生》2017年01期

【摘要】：目的探討生物鐘基因(CLOCK)多態(tài)性與原發(fā)性男性不育之間的關(guān)系。方法以2005—2010年就診于江蘇省南京醫(yī)科大學(xué)附屬醫(yī)院男性不育門診的478例患者為病例組,同時(shí)選擇就診于其他門診的有正常生育史的194名男性為對照組。取5 m L外周血檢測血清睪酮(T)和促卵泡激素(FSH)水平,PCR檢測CLOCK的rs1801260、rs3817444和rs3749474位點(diǎn)。結(jié)果在rs3749474位點(diǎn)攜帶TT基因型和TC+CC基因型的受試者中病例組血清FSH濃度明顯高于對照組(P=0.0266),攜帶CC基因型的受試者中病例組血清T濃度明顯高于對照組(P=0.0466);在rs1801260位點(diǎn)攜帶AA基因型的受試者中病例組血清FSH和T濃度均明顯高于對照組(P分別為0.0016、0.0451);在rs3817444位點(diǎn)攜帶CC基因型和CA+AA基因型的受試者中病例組血清FSH濃度均明顯高于對照組(P分別為0.0016、0.0430)。結(jié)論 CLOCK基因多態(tài)性與原發(fā)性男性不育存在關(guān)聯(lián)。
[Abstract]:Objective to investigate the relationship between the polymorphism of clock gene and primary male sterility. Methods 478 male infertility patients from 2005 to 2010 in Nanjing Medical University affiliated Hospital of Jiangsu Province were selected as case group and 194 men with normal fertility history as control group. The levels of serum testosterone (T) and follicle stimulating hormone (FSH) were measured in 5 mL peripheral blood. The rs1801260 rs3817444 and rs3749474 loci of CLOCK were detected by PCR. Results the serum FSH concentration in the patients with TT genotype and TC CC genotype at rs3749474 locus was significantly higher than that in the control group (P 0.0266), the serum T concentration in the case group with CC genotype was significantly higher than that in the control group, and in the rs1801260 locus, the serum T concentration in the case group was significantly higher than that in the control group. The serum FSH and T concentrations in the patients with AA genotype were significantly higher than those in the control group (P = 0.0016, P = 0.0451, respectively), and the serum FSH concentrations in the patients with CC genotype and CA AA genotype at the rs3817444 locus were significantly higher than those in the control group (P = 0.0016, P = 0.0430, respectively). Conclusion CLOCK gene polymorphism is associated with primary male infertility.
【作者單位】： 蘇州大學(xué)公共衛(wèi)生學(xué)院衛(wèi)生毒理學(xué)教研室;
【基金】：國家自然科學(xué)基金(81473008) 蘇州市科技項(xiàng)目(SYS201320)
【分類號】：R698.2

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