本文選題：慢性心力衰竭 + 基因型��； 參考：《石河子大學(xué)》2017年碩士論文

【摘要】：目的:通過對KCNE1基因G38S基因分型,統(tǒng)計(jì)分析新疆維吾爾族射血分?jǐn)?shù)減少型慢性心力衰竭患者(病例組)與對照組(無慢性心力衰竭患者)AA、AG、GG基因型及等位基因A、G頻率分布。簡述KCNE1基因G38S多態(tài)性與維吾爾族慢性心力衰竭的相關(guān)性。方法:選取2014年12月至2016年7月新疆維吾爾自治區(qū)人民醫(yī)院就診的維吾爾族患者中病例組200例,對照組200例。分別對兩組進(jìn)行基因分型,MSPA1酶切檢測。結(jié)果:KCNE1基因G38S AA、AG、GG基因型人數(shù)在病例組為24(12.0%)、89(44.5%)、87(43.5%),對照組分別為37(18.5%)、91(45.5%)、72(36.0%)。等位基因A、G病例組為137(34.25%),263(65.75%),對照組為165(41.25%),235(58.75%)。病例組和對照組均符合Hardy-Weinberg平衡檢驗(yàn),具有群體代表性,P值均0.05。病例組和對照組中AG基因型較AA型和GG型增多,但統(tǒng)計(jì)學(xué)分析兩組之間基因型比較無統(tǒng)計(jì)學(xué)差異(χ2=4.208,P=0.122),等位基因頻率兩組比較有統(tǒng)計(jì)學(xué)意義(χ2=4.170,P=0.041)。兩組內(nèi)男女基因型及等位基因頻率統(tǒng)計(jì)分析無統(tǒng)計(jì)學(xué)意義(P0.05)。經(jīng)logistic回歸模型顯示左室舒張末內(nèi)徑的OR值為1.473,β=0.387,95%CI:(1.357~1.599),QRS時(shí)限OR值為1.028,β=0.027,95%CI:(1.009~1.047),性別的OR值為2.288,β=0.828,95%CI:(1.059~4.943),冠心病的OR值為3.047,β=1.114,95%CI:(1.532~6.063),糖尿病OR值為3.200,β=1.163,95%CI:(1.345~7.562)�；蛐虯G的OR值為0.489,β=-0.715,95%CI:(0.247~0.966)。結(jié)論:1.維吾爾族慢性心力衰竭患者中KCNE1基因G38S攜帶G等位基因頻率高于對照組(無慢性心力衰竭患者);2.左室舒張末徑增加、QRS波時(shí)限延長、男性、冠心病、糖尿病均是慢性心力衰竭的危險(xiǎn)因素,攜帶AG基因型發(fā)生慢性心力衰竭的風(fēng)險(xiǎn)小,基因型AG可能為發(fā)生慢性心力衰竭的保護(hù)因素,KCNE1基因G38S多態(tài)性與維吾爾族慢性心力衰竭具有相關(guān)性。
[Abstract]:Objective: to analyze the frequency distribution of KCNE1 gene GG genotype and allele in Xinjiang Uygur patients (case group) and control group (control group) by G38S genotyping of KCNE1 gene. The association between KCNE1 gene G38S polymorphism and Uygur chronic heart failure was briefly described. Methods: from December 2014 to July 2016, 200 cases of Uygur patients in Xinjiang Uygur Autonomous region people's Hospital and 200 cases of control group were selected. The genotyping of MSPA1 was detected in two groups. Results the GG genotypes of G38S AAAAGG of the KCNE1 gene were 240.12.0 and 898944.5in the case group. The GG genotypes of the G38S AAAGG gene of the KCNE1 gene were as follows: in the case group, the GG genotypes of the G38S AAAAGG gene were 240.12.0 and 898944.5in the case group, and in the control group the GG genotypes of the G38S AAAAGG gene were 37 ~ 18.5A / 45.5C, respectively. The alleles of allele Agna G in the case group were 137 / 34.25 / 263N / 65.75, and in the control group were 165 / 41.25 / 235 / 58.75g / L, respectively. Both the case group and the control group were in accordance with Hardy-Weinberg balance test, and the P value of group representative was 0.05. AG genotype was higher in case group and control group than that in AA type and GG type, but there was no significant difference in genotype between two groups (蠂 ~ 2 / 4.208). Allele frequency was significantly higher in two groups (蠂 ~ 2 / 4.170) (蠂 ~ (2) = 4.170) (P = 0.041). There was no significant difference in the frequency of genotype and allele between male and female in the two groups (P 0.05). The logistic regression model showed that the OR value of left ventricular end-diastolic diameter was 1.473, the OR value of 尾 0.38795 CIW 1.3571.599 QRS was 1.028, 尾 0.02795CIW 1.00995 CIW 1.0091.047m, the OR value of gender was 2.288, 尾 0.82895CIU 1.0594.943, the OR value of coronary heart disease was 3.047, 尾 1.11495 CICell 1.5326.06363, the OR value of diabetes was 3.200, 尾 1.16395CIU was 1.3457.562. The OR value of genotype AG was 0.489, and 尾 -0.715 + 95% CI: 0.247 ~ 0.966. Conclusion 1. The frequency of G allele of KCNE1 gene G38S in Uygur patients with chronic heart failure was higher than that in control group. Left ventricular end-diastolic diameter increased QRS wave duration. Men, coronary heart disease, diabetes mellitus were risk factors of chronic heart failure, and had a low risk of chronic heart failure with AG genotype. Genotype AG may be a protective factor for chronic heart failure. The G38S polymorphism of KCNE1 gene is associated with chronic heart failure in Uygur nationality.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R541.6

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