HPA基因多態(tài)性及其等位基因?qū)ρ“遢斪⑿Ч挠绊?/H1>
發(fā)布時(shí)間：2018-04-26 12:25
本文選題：HPA基因多態(tài)性 + 血小板��； 參考：《中國(guó)輸血雜志》2017年07期
【摘要】：目的探討HPA基因多態(tài)性及其等位基因?qū)ρ“遢斪⑿Ч挠绊憽７椒ㄗ?015年1月-2017年1月,連續(xù)性收集50例本院收治的血小板輸注無(wú)效患者作為觀察組,同期收集50例血小板輸注有效的患者作為對(duì)照組,觀察2組患者HPA基因多態(tài)性。結(jié)果與對(duì)照組比較,觀察組患者供患雙方HPA分型相合率顯著降低(4.00%vs 82.00%,P0.05);血小板恢復(fù)百分比顯著降低[(11.91±3.23)%vs(31.56±7.38)%,P0.05);血小板糾正增加指數(shù)顯著降低(6.84±2.27 vs 16.38±1.92,P0.05)。2組患者HPA等位基因(HPA1-6,9,15)均以純合子aa為多見(jiàn)。但觀察組HPA-2等位基因?yàn)閍a、ab、bb的分別有37、8、5例,對(duì)照組分別有48、2、0例,差異有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組HPA-3等位基因?yàn)閍a、ab、bb的分別有33、9、8例,對(duì)照組分別有46、3、1例,差異有統(tǒng)計(jì)學(xué)差異(P0.05)。觀察組HPA-15等位基因?yàn)閍a、ab、bb的分別有35、8、7例,對(duì)照組分別有47、2、1例,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。2組患者的血小板供者HPA等位基因(HPA1-6,9,15)均以純合子aa為多見(jiàn),差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。血小板輸注無(wú)效患者HPA-2,3等位基因?yàn)閍a、ab和bb的血小板恢復(fù)百分比、血小板糾正增加指數(shù)逐步下降(P0.05)。結(jié)論血小板輸注無(wú)效與HPA基因多態(tài)性有關(guān),等位基因型b可能是導(dǎo)致血小板輸注無(wú)效的原因。
[Abstract]:Objective to investigate the effect of HPA gene polymorphism and its allele on platelet transfusion. Methods from January 2015 to January 2017, 50 consecutive patients with ineffective platelet transfusion were collected as observation group and 50 patients with effective platelet transfusion as control group. The polymorphism of HPA gene was observed in both groups. Results compared with the control group, In the observation group, the consistent rate of HPA typing was significantly decreased by 4.00 vs 82.00, the percentage of platelet recovery was significantly decreased [11.91 鹵3.23)%vs(31.56 鹵7.38] and the platelet correction index was significantly decreased (6.84 鹵2.27 vs 16.38 鹵1.92 P0.05.2). However, the HPA-2 allele of the observation group was aaaababanbb (37 / 85) and the control group (48 / 22), the difference was statistically significant (P0.05), the HPA-3 allele of the observation group was aaaababambb (339 / 8) and the control group (466 / 31), respectively (P 0.05). In the observation group, the allele of HPA-15 was aaaababanbb in 37 cases and that in the control group was 47 cases. The difference between the two groups was statistically significant (P 0.05). The homozygote AA was the most common allele in the platelet donor group (P 0.05), and there was no significant difference in the difference between the two groups (P 0. 05%, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05). The alleles of HPA-2M3 in patients with ineffective platelet transfusion were the percentage of platelet recovery of aaqinab and BB, and the increase index of platelet correction decreased gradually (P 0.05). Conclusion HPA gene polymorphism is associated with platelet transfusion failure, and allelic genotype b may be the cause of platelet transfusion failure.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院輸血科;
【基金】：上海市衛(wèi)生計(jì)劃委員會(huì)項(xiàng)目 上海市第四輪公共衛(wèi)生重點(diǎn)學(xué)科建設(shè)項(xiàng)目(15GWZK0501)
【分類(lèi)號(hào)】：R457.1
【相似文獻(xiàn)】
相關(guān)期刊論文 前10條
1 ;腫瘤病人血小板輸注效果及現(xiàn)狀分析[J];中國(guó)輸血雜志;2001年S1期
2 ;血小板輸注的臨床應(yīng)用[J];中國(guó)輸血雜志;2001年S1期
3 楊復(fù),陳天榮;135例血小板輸注效果臨床分析[J];血栓與止血學(xué);2001年02期
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7 王兆鉞;血小板輸注及其無(wú)效輸注[J];中國(guó)實(shí)用內(nèi)科雜志;2004年09期
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9 羅凌飛;郭宗明;羅文達(dá);;血小板輸注對(duì)血小板減少性疾病臨床效果觀察[J];浙江實(shí)用醫(yī)學(xué);2006年04期
10 李津金;陳寶安;黃成垠;李翠萍;史廣耀;肖建宇;丁家華;高沖;孫耘玉;王駿;程堅(jiān);趙剛;宋慧慧;仲悅嬌;;活化血漿凝固時(shí)間對(duì)血小板輸注療效評(píng)價(jià)的研究[J];中國(guó)實(shí)驗(yàn)血液學(xué)雜志;2007年01期
相關(guān)會(huì)議論文 前10條
1 吳家新;;94例血小板輸注效果臨床分析[A];中華醫(yī)學(xué)會(huì)第八次全國(guó)檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議暨中華醫(yī)學(xué)會(huì)檢驗(yàn)分會(huì)成立30周年慶典大會(huì)資料匯編[C];2009年
2 陳春霞;秦莉;;預(yù)防性血小板輸注研究進(jìn)展[A];中華醫(yī)學(xué)會(huì)第九次全國(guó)檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議暨中國(guó)醫(yī)院協(xié)會(huì)臨床檢驗(yàn)管理專(zhuān)業(yè)委員會(huì)第六屆全國(guó)臨床檢驗(yàn)實(shí)驗(yàn)室管理學(xué)術(shù)會(huì)議論文匯編[C];2011年
3 趙敬湘;宋直，
本文編號(hào)：1806016
本文鏈接：http://sikaile.net/kejilunwen/jiyingongcheng/1806016.html
本文選題：HPA基因多態(tài)性 + 血小板��； 參考：《中國(guó)輸血雜志》2017年07期
【摘要】：目的探討HPA基因多態(tài)性及其等位基因?qū)ρ“遢斪⑿Ч挠绊憽７椒ㄗ?015年1月-2017年1月,連續(xù)性收集50例本院收治的血小板輸注無(wú)效患者作為觀察組,同期收集50例血小板輸注有效的患者作為對(duì)照組,觀察2組患者HPA基因多態(tài)性。結(jié)果與對(duì)照組比較,觀察組患者供患雙方HPA分型相合率顯著降低(4.00%vs 82.00%,P0.05);血小板恢復(fù)百分比顯著降低[(11.91±3.23)%vs(31.56±7.38)%,P0.05);血小板糾正增加指數(shù)顯著降低(6.84±2.27 vs 16.38±1.92,P0.05)。2組患者HPA等位基因(HPA1-6,9,15)均以純合子aa為多見(jiàn)。但觀察組HPA-2等位基因?yàn)閍a、ab、bb的分別有37、8、5例,對(duì)照組分別有48、2、0例,差異有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組HPA-3等位基因?yàn)閍a、ab、bb的分別有33、9、8例,對(duì)照組分別有46、3、1例,差異有統(tǒng)計(jì)學(xué)差異(P0.05)。觀察組HPA-15等位基因?yàn)閍a、ab、bb的分別有35、8、7例,對(duì)照組分別有47、2、1例,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。2組患者的血小板供者HPA等位基因(HPA1-6,9,15)均以純合子aa為多見(jiàn),差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。血小板輸注無(wú)效患者HPA-2,3等位基因?yàn)閍a、ab和bb的血小板恢復(fù)百分比、血小板糾正增加指數(shù)逐步下降(P0.05)。結(jié)論血小板輸注無(wú)效與HPA基因多態(tài)性有關(guān),等位基因型b可能是導(dǎo)致血小板輸注無(wú)效的原因。
[Abstract]:Objective to investigate the effect of HPA gene polymorphism and its allele on platelet transfusion. Methods from January 2015 to January 2017, 50 consecutive patients with ineffective platelet transfusion were collected as observation group and 50 patients with effective platelet transfusion as control group. The polymorphism of HPA gene was observed in both groups. Results compared with the control group, In the observation group, the consistent rate of HPA typing was significantly decreased by 4.00 vs 82.00, the percentage of platelet recovery was significantly decreased [11.91 鹵3.23)%vs(31.56 鹵7.38] and the platelet correction index was significantly decreased (6.84 鹵2.27 vs 16.38 鹵1.92 P0.05.2). However, the HPA-2 allele of the observation group was aaaababanbb (37 / 85) and the control group (48 / 22), the difference was statistically significant (P0.05), the HPA-3 allele of the observation group was aaaababambb (339 / 8) and the control group (466 / 31), respectively (P 0.05). In the observation group, the allele of HPA-15 was aaaababanbb in 37 cases and that in the control group was 47 cases. The difference between the two groups was statistically significant (P 0.05). The homozygote AA was the most common allele in the platelet donor group (P 0.05), and there was no significant difference in the difference between the two groups (P 0. 05%, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05). The alleles of HPA-2M3 in patients with ineffective platelet transfusion were the percentage of platelet recovery of aaqinab and BB, and the increase index of platelet correction decreased gradually (P 0.05). Conclusion HPA gene polymorphism is associated with platelet transfusion failure, and allelic genotype b may be the cause of platelet transfusion failure.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院輸血科;
【基金】：上海市衛(wèi)生計(jì)劃委員會(huì)項(xiàng)目 上海市第四輪公共衛(wèi)生重點(diǎn)學(xué)科建設(shè)項(xiàng)目(15GWZK0501)
【分類(lèi)號(hào)】：R457.1
【相似文獻(xiàn)】
相關(guān)期刊論文 前10條
1 ;腫瘤病人血小板輸注效果及現(xiàn)狀分析[J];中國(guó)輸血雜志;2001年S1期
2 ;血小板輸注的臨床應(yīng)用[J];中國(guó)輸血雜志;2001年S1期
3 楊復(fù),陳天榮;135例血小板輸注效果臨床分析[J];血栓與止血學(xué);2001年02期
4 俞穎;當(dāng)前血小板輸注的進(jìn)展及相關(guān)問(wèn)題[J];浙江臨床醫(yī)學(xué);2002年04期
5 侯玲;預(yù)防性血小板輸注臨床效果觀察[J];航空航天醫(yī)藥;2003年01期
6 孟君霞,夏玉彬,李新剛,劉秀文;機(jī)采濃縮血小板輸注療效觀察[J];中原醫(yī)刊;2003年12期
7 王兆鉞;血小板輸注及其無(wú)效輸注[J];中國(guó)實(shí)用內(nèi)科雜志;2004年09期
8 崔云華;劉麗萍;王朝霞;;巧制血小板輸注管[J];護(hù)理學(xué)雜志;2006年01期
9 羅凌飛;郭宗明;羅文達(dá);;血小板輸注對(duì)血小板減少性疾病臨床效果觀察[J];浙江實(shí)用醫(yī)學(xué);2006年04期
10 李津金;陳寶安;黃成垠;李翠萍;史廣耀;肖建宇;丁家華;高沖;孫耘玉;王駿;程堅(jiān);趙剛;宋慧慧;仲悅嬌;;活化血漿凝固時(shí)間對(duì)血小板輸注療效評(píng)價(jià)的研究[J];中國(guó)實(shí)驗(yàn)血液學(xué)雜志;2007年01期
相關(guān)會(huì)議論文 前10條
1 吳家新;;94例血小板輸注效果臨床分析[A];中華醫(yī)學(xué)會(huì)第八次全國(guó)檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議暨中華醫(yī)學(xué)會(huì)檢驗(yàn)分會(huì)成立30周年慶典大會(huì)資料匯編[C];2009年
2 陳春霞;秦莉;;預(yù)防性血小板輸注研究進(jìn)展[A];中華醫(yī)學(xué)會(huì)第九次全國(guó)檢驗(yàn)醫(yī)學(xué)學(xué)術(shù)會(huì)議暨中國(guó)醫(yī)院協(xié)會(huì)臨床檢驗(yàn)管理專(zhuān)業(yè)委員會(huì)第六屆全國(guó)臨床檢驗(yàn)實(shí)驗(yàn)室管理學(xué)術(shù)會(huì)議論文匯編[C];2011年
3 趙敬湘;宋直，
本文編號(hào)：1806016
本文鏈接：http://sikaile.net/kejilunwen/jiyingongcheng/1806016.html
