本文選題：原發(fā)性血小板增多癥 + Jak��； 參考：《中國老年學雜志》2017年18期

【摘要】：目的探討老年原發(fā)性血小板增多癥(ET)患者Jak2基因v617f點突變檢測的臨床意義。方法老年ET患者100例,檢測Jak2基因v617f點突變,根據(jù)檢測結果分為陰性組(n=54)與陽性組(n=46),比較兩組年齡、性別、脾腫大、骨髓巨核細胞數(shù)、實驗室檢查指標及血栓發(fā)生率、出血率。結果兩組年齡、性別、脾腫大及骨髓巨核細胞數(shù)差異均無統(tǒng)計學意義(均P0.05)。陽性組白細胞計數(shù)(WBC)水平顯著高于陰性組(P0.05),兩組血紅蛋白(HGB)、血小板計數(shù)(PLT)水平比較差異無統(tǒng)計學意義(P0.05)。陽性組血栓發(fā)生率顯著高于陰性組(P0.05),兩組出血率比較差異無統(tǒng)計學意義(P0.05)。結論 Jak2基因v617f點突變檢測有利于輔助臨床診斷老年ET,有效評估患者疾病狀態(tài),并為臨床治療和預防血栓的發(fā)生提供參考依據(jù)。
[Abstract]:Objective to investigate the clinical significance of Jak2 v617 f point mutation in elderly patients with idiopathic thrombocytopenia. Methods the point mutation of Jak2 gene v617f was detected in 100 elderly patients with et. The results were divided into negative group (n = 54) and positive group (n = 46). The age, sex, splenomegaly, bone marrow megakaryocyte number, laboratory examination index, thrombosis rate and bleeding rate were compared between the two groups. Results there was no significant difference in age, sex, splenomegaly and the number of bone marrow megakaryocytes between the two groups (P 0.05). The level of WBCC in the positive group was significantly higher than that in the negative group (P 0.05), but there was no significant difference between the two groups in the levels of HGB and PLT (P 0.05). The incidence of thrombus in the positive group was significantly higher than that in the negative group (P 0.05). There was no significant difference in the bleeding rate between the two groups. Conclusion the detection of v617f point mutation of Jak2 gene is helpful for the diagnosis of senile ETS, the evaluation of disease status, and the reference for clinical treatment and prevention of thrombus.
【作者單位】： 惠州市中心人民醫(yī)院血液科;
【基金】：惠州市科技計劃項目(No.20160801)
【分類號】：R558.3
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本文編號：1786321