發(fā)布時(shí)間：2018-03-21 01:05

  本文選題：腸易激綜合征　切入點(diǎn)：安腸湯　出處：《遼寧中醫(yī)雜志》2017年10期 　論文類型：期刊論文

【摘要】：目的:研究安腸湯對(duì)IBS-D大鼠mGluR5,NR2BR基因在脊髓背角表達(dá)變化,介導(dǎo)疼痛中樞敏化機(jī)制探討安腸湯緩解IBS-D腹痛的作用機(jī)制。方法:40只清潔雄性SD大鼠隨機(jī)分為4組,10只/組,正常組、模型組、西藥組、中藥組。采用番瀉葉+束縛應(yīng)激法造模。治療組和對(duì)照組分別予安腸湯及得舒特片2周。結(jié)果:模型組腰段脊髓背角中的m GluR5,NR2BR基因表達(dá)與另外3組對(duì)比明顯增高,P0.05;西藥組和中藥組相比,P0.05。結(jié)論:說(shuō)明m GluR5,NR2BR基因參與IBS-D大鼠疼痛信號(hào)中樞敏化機(jī)制;安腸湯可以有效調(diào)控m GluR5,NR2BR基因在腰段脊髓中的表達(dá),從而達(dá)到緩解腹痛癥狀。
[Abstract]:Objective: to study the effect of Anchang decoction on the expression of mGluR5 and NR2BR gene in the dorsal horn of spinal cord in IBS-D rats and to explore the mechanism of relieving abdominal pain of IBS-D by mediating the mechanism of pain center sensitization. Methods: forty clean male Sprague-Dawley rats were randomly divided into 4 groups (n = 10) and normal group (n = 10). Model group, western medicine group, Treatment group and control group were treated with Anchang decoction and Desuter tablet for 2 weeks respectively. Results: the expression of m GluR5 + NR2BR gene in the lumbar spinal dorsal horn of model group was significantly higher than that in the other three groups. Conclusion: mGluR5NR2BR gene is involved in the central sensitization mechanism of pain signal in IBS-D rats. Anchang decoction can effectively regulate the expression of m GluR5 and NR2BR gene in the lumbar spinal cord, thus relieving abdominal pain.
【作者單位】： 廣西中醫(yī)藥大學(xué)附屬瑞康醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金(81560754) 廣西自然科學(xué)基金(2015GXNSFAA139199)
【分類號(hào)】：R285.5
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本文編號(hào)：1641584