本文選題：原發(fā)性血小板增多癥　切入點：網(wǎng)織血小板　出處：《世界最新醫(yī)學信息文摘》2016年72期 　論文類型：期刊論文

【摘要】：目的 探究網(wǎng)織血小板及JAK2V617基因突變檢測對于原發(fā)性血小板增多癥(ET)評估血栓發(fā)生率;方法 在ET患者中用SY Sysmex XE-5000血細胞分析儀及配套原裝試劑測定網(wǎng)織血小板,用RT-PCR測定JAK2V617基因突變,通過對網(wǎng)織血小板及JAK2V617基因突變檢測對原發(fā)性血小板增多癥中血栓發(fā)生率進行評估;結(jié)果 c2檢驗分析,P0.05,差異有統(tǒng)計學意義,可以認為網(wǎng)織血小板與血栓有正相關(guān)關(guān)系、JAK2基因突變與血栓存在正相關(guān)關(guān)系;Logistics回歸分析顯示JAK2V617基因突變陽性,血栓發(fā)生事件OR(odds ratio,比值比)為4.453,P0.05;網(wǎng)織血小板升高,血栓發(fā)生事件OR為4.400,P0.05。兩項因素OR均大于1,表明其均使血栓發(fā)生危險性增高,兩者均是血栓升高的獨立危險因素。結(jié)論 網(wǎng)織血小板數(shù)值升高、JAK2V617基因突變陽性與ET患者發(fā)生血栓率成正比,JAK2基因突變及網(wǎng)織血小板成為評估血栓早期發(fā)生的檢查手段。
[Abstract]:Objective to evaluate the incidence of thrombus in patients with idiopathic thrombocytosis by reticulocyte and JAK2V617 gene mutation. The incidence of thrombus in patients with idiopathic thrombocytosis was evaluated by RT-PCR, reticulocyte and JAK2V617 gene mutation. It can be concluded that there is a positive correlation between reticulocyte and thrombus. The positive correlation between JAK2 gene mutation and thrombus was found by logistic regression analysis. The positive rate of JAK2V617 gene mutation and the ratio ratio of OR(odds to thrombogenesis were 4.453p0.05. reticulocyte increased. The OR of thrombogenesis events was 4.400 p 0.05.The OR of both factors was greater than 1, which indicated that both factors increased the risk of thrombosis. Conclusion the positive mutation of JAK2V617 gene is directly proportional to the incidence of thrombus in patients with et.
【作者單位】： 吉林市中心醫(yī)院血液科吉林市北華大學;
【分類號】：R733.3

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