發(fā)布時(shí)間：2018-03-09 19:42

  本文選題：肝細(xì)胞核因子A基因　切入點(diǎn)：糖尿病　出處：《中國(guó)糖尿病雜志》2017年08期 　論文類型：期刊論文

【摘要】：目的探討肝細(xì)胞核因子1A(HNF1A)基因單核苷酸多態(tài)性(SNP)位點(diǎn)rs2464196,rs1169288和rs1169289與維吾爾族T2DM的相關(guān)性,以及SNP-環(huán)境危險(xiǎn)因素交互用對(duì)T2DM易感性的影響。方法在烏魯木齊市選取156例T2DM患者(T2DM組)和248名健康人(NC組),進(jìn)行基因多態(tài)性檢測(cè)和交互作用分析。結(jié)果 rs2464196位點(diǎn)AG基因型和吸煙的交互作用與T2DM的風(fēng)險(xiǎn)相關(guān)(OR=2.284,P=0.041)。rs2464196位點(diǎn)AG基因型和高LDL-C水平的交互作用會(huì)增加T2DM風(fēng)險(xiǎn)(OR=4.157,P=0.005),rs2464196位點(diǎn)GG基因型與高TG、低HDL-C和高LDL-C交互作用增加維吾爾族T2DM的易感性(OR=2.908、3.058、5.619)。rs1169288位點(diǎn)TG基因型與高TC、高TG、低HDL-C和高LDL-C交互作用增加維吾爾族T2DM的易感性(OR=2.793、4.076、5.043、4.649)。GG基因型與高TG、低HDL-C和高LDL-C存在交互增加疾病易感性(OR=2.461、3.042、3.638)。rs1169289位點(diǎn)CG基因型與吸煙和高LDL-C存在交互(OR=5.370、4.575)。GG基因型與高TC、高TG、低HDL-C和高LDL-C有交互增加T2DM易感性(OR=2.250、2.170、2.999、4.217)。結(jié)論 HNF1A基因多態(tài)性rs2464196,rs1169288和rs1169289與吸煙、血脂異常的交互作用可能影響維吾爾族T2DM的易感性。
[Abstract]:Objective to investigate the association of single nucleotide polymorphisms rs2464196 (rs1169288) and rs1169289 with T2DM in Uygur population. Methods in Urumqi, 156 patients with T2DM and 248 healthy controls were selected to detect the gene polymorphism and analyze the interaction of T2DM. The interaction between AG genotype and smoking was associated with the risk of T2DM. The interaction between AG genotype and high LDL-C level increased the risk of T2DM. Low HDL-C and high LDL-C interaction increased Uygur T2DM. The interaction of TG genotype with high Tc, high TGG, low HDL-C and high LDL-C increased the susceptibility of Uygur T2DM to the genotype of OR2.7934.0765.043.0434.649.GG, low HDL-C and high LDL-C interactively increased susceptibility to disease. In LDL-C, the genotype of ORO 5.370 4.575A. GG and high Tc, high TGG, low HDL-C and high LDL-C interactively increased the susceptibility to T2DM. Conclusion the polymorphism of HNF1A gene rs2464196rs1169288 and rs1169289 are associated with smoking, and the susceptibility to T2DM is 2.250 / 2.170 / 2.999 / 4.2170.Conclusion the polymorphism of HNF1A gene rs2464196rs1169288 and rs1169289 are associated with smoking. The interaction of dyslipidemia may affect the susceptibility of Uygur to T2DM.
【作者單位】： 新疆醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院;新疆醫(yī)科大學(xué)第五附屬醫(yī)院內(nèi)分泌科;新疆醫(yī)科大學(xué)公共衛(wèi)生學(xué)院;
【基金】：國(guó)家自然科學(xué)基金(81360127) 新疆維吾爾自治區(qū)自然科學(xué)基金(2016D01C191) 新疆醫(yī)科大學(xué)科研創(chuàng)新基金項(xiàng)目(XJC201308)
【分類號(hào)】：R587.1

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本文編號(hào)：1589976