本文選題：冠心病　切入點：基因多態(tài)性　出處：《中華中醫(yī)藥學刊》2016年05期 　論文類型：期刊論文

【摘要】：基于基因-體質(zhì)-證候三者之間的必然聯(lián)系,提出以體質(zhì)為中間橋梁連接冠心病證候與基因多態(tài)性,通過基因-體質(zhì)-證候這一研究模式探討冠心病證候的研究思路。繼而分析了體質(zhì)與冠心病證候關(guān)系、冠心病常見體質(zhì)及常見證候類型的基因多態(tài)性研究現(xiàn)狀,并進行了相關(guān)研究方法的分析,以期為此研究模式提出可行的研究方案。通過冠心病瘀血質(zhì)、氣虛質(zhì)和痰濕質(zhì)三種常見體質(zhì)及血瘀證、痰濁證、痰瘀互結(jié)證3種常見證候基因多態(tài)性現(xiàn)有研究的分析與綜合,提出了可供選擇及進一步薈萃分析的候選基因。通過比較候選基因及全基因組研究方法,結(jié)合此模式的研究特點提出運用高通量的列陣技術(shù)進行候選基因研究。同時,通過分析也發(fā)現(xiàn)了樣本選擇收集、候選基因選擇及冠心病作為多基因遺傳病之間的問題有待于進一步研究的解決。
[Abstract]:Based on the inevitable relationship between gene-physique syndrome and syndromes, it is proposed that physique is the intermediate bridge between coronary heart disease syndrome and gene polymorphism. Through the research mode of gene-physique syndrome, this paper discusses the research ideas of coronary heart disease syndrome, and then analyzes the relationship between constitution and coronary heart disease syndrome, the gene polymorphism of common constitution and common syndrome type of coronary heart disease. And the related research methods were analyzed in order to put forward a feasible research plan for this research model. Through three common physique of coronary heart disease blood stasis, qi deficiency and phlegm dampness, and blood stasis syndrome, phlegm turbid syndrome, Based on the analysis and synthesis of three common syndromes gene polymorphisms in phlegm and blood stasis syndromes, the candidate genes for selection and further meta-analysis were put forward. According to the characteristics of this model, a high-throughput array technique is used to study candidate genes. At the same time, the sample selection collection is also found through the analysis. The problems of candidate gene selection and coronary heart disease as polygenic diseases need to be further studied.
【作者單位】： 遼寧中醫(yī)藥大學中醫(yī)臟象理論及應(yīng)用教育部重點實驗室;
【基金】：國家重點基礎(chǔ)研究發(fā)展計劃(973計劃)項目(2013CB531704) 遼寧省科學技術(shù)計劃項目(2014225004)
【分類號】：R259

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