12名生長激素/泌乳素混合性垂體瘤病人的案例分析
發(fā)布時間:2024-04-21 02:42
目的:混合型生長激素(Growth Hormone,GH)和泌乳素(Prolactin,PRL)垂體瘤是部分具有侵襲性的一種腫瘤。它們GH/PRL免疫染色陽性,是最常見的混合型垂體瘤,大約占所有已切除垂體瘤的10-30%。盡管有很多”假”GH/PRL垂體瘤的報道(由于巨大腫瘤的垂體柄效應(yīng)導(dǎo)致的E-鈣離子依賴的細胞粘附素轉(zhuǎn)變成鈣離子依賴的細胞粘附素18,使GH轉(zhuǎn)變成PRL而導(dǎo)致的PRL的輕度增加即<150 ng/ml),但是真正的GH-PRL垂體腺瘤的臨床報道和流行病學(xué)統(tǒng)計并不多見,特別是在中國和其他東亞國家。本次論文的目的在于討論根治性切除術(shù)(Transsphenoidal Surgery,TS)對于這種真正的GH-PRL腺瘤的影響包括手術(shù)結(jié)果,并發(fā)癥和預(yù)后以幫助臨床醫(yī)生在未來針對此類病人選擇更合適的治療手段。方法和病人:該論文進行了 12個GH-PRL混合型垂體瘤病人的回顧性研究(7男,5女),他們皆于2010年至2018年間由中國,山東省,山東大學(xué)附屬齊魯醫(yī)院收入院和治療。我們首先給這些病人使用了多巴胺激動劑(溴隱亭)和生長抑素類似物以控制PRL、GH和PRL的水平。然后,全...
【文章頁數(shù)】:70 頁
【學(xué)位級別】:碩士
【文章目錄】:
Abbreviations and acronyms
中文摘要
ABSTRACT
Chapter One Preface
1.1 Introduction
1.2 Aim
1.3 Objectives
Chapter Two Literature Review
2.1 Hypophyseal Gland
2.2 Pituitary Adenomas Overview
2.3 Development patterns of PAs
2.4 Classification of PAs
2.5 History of TS surgery
2.6 Cavernous Sinus Invasion
2.7 PA Residual and Recurrence
2.8 The Measureimnt of Cell Proliferation (K卜67/MIB-1 Index)
2.9 Advanced Therapeutic Targets in PA
Chapter Three Patients and methods
3.1 Ethics statement
3.2 Patients
3.3 Hormones measurement
3.4 Pathological assay
3.5 Glassification of pituitary adenomas
3.6 Treatment protocol
3.7 Surgical technique
3.8 Statistical analysis
Chapter Four Results
4.1 Specifications of patients
4.2 Imaging
4.3 Laboratory features
4.4 ImmunohistochemicaI assay
4.5 Surgical outcomes, postoperative complications,and recurrence of the patients
Chapter Five
5.1 DISCUSSION
5.2 Conclusion
REFERENCES
APPENDIX
ACKNOWLEDGEMENT
學(xué)位論文評閱及答辯情況表
本文編號:3960299
【文章頁數(shù)】:70 頁
【學(xué)位級別】:碩士
【文章目錄】:
Abbreviations and acronyms
中文摘要
ABSTRACT
Chapter One Preface
1.1 Introduction
1.2 Aim
1.3 Objectives
Chapter Two Literature Review
2.1 Hypophyseal Gland
2.2 Pituitary Adenomas Overview
2.3 Development patterns of PAs
2.4 Classification of PAs
2.5 History of TS surgery
2.6 Cavernous Sinus Invasion
2.7 PA Residual and Recurrence
2.8 The Measureimnt of Cell Proliferation (K卜67/MIB-1 Index)
2.9 Advanced Therapeutic Targets in PA
Chapter Three Patients and methods
3.1 Ethics statement
3.2 Patients
3.3 Hormones measurement
3.4 Pathological assay
3.5 Glassification of pituitary adenomas
3.6 Treatment protocol
3.7 Surgical technique
3.8 Statistical analysis
Chapter Four Results
4.1 Specifications of patients
4.2 Imaging
4.3 Laboratory features
4.4 ImmunohistochemicaI assay
4.5 Surgical outcomes, postoperative complications,and recurrence of the patients
Chapter Five
5.1 DISCUSSION
5.2 Conclusion
REFERENCES
APPENDIX
ACKNOWLEDGEMENT
學(xué)位論文評閱及答辯情況表
本文編號:3960299
本文鏈接:http://sikaile.net/yixuelunwen/zlx/3960299.html
最近更新
教材專著