【摘要】：目的探討原發(fā)性肝癌(HCC)患者氬氦冷凍消融術(shù)前外周血中性粒細(xì)胞與淋巴細(xì)胞比值(neutrophil to lymphocyte ratio,NLR)對(duì)患者預(yù)后的影響。方法回顧性分析72例HCC患者行經(jīng)皮穿刺氬氦冷凍消融術(shù)的相關(guān)臨床病理資料。根據(jù)術(shù)前NLR,分為低NLR組(NLR3.5)和高NLR組(NLR≥3.5),統(tǒng)計(jì)分析兩組患者術(shù)后的總生存期(overall survival,OS),并對(duì)其影響預(yù)后的危險(xiǎn)因素進(jìn)行單因素和多因素分析。結(jié)果所有患者經(jīng)氬氦冷凍消融治療后,中位生存期為22.4個(gè)月,其中高NLR組的中位生存期為13.2個(gè)月,低NLR組的中位生存期為24.2個(gè)月,兩組中位生存期差異有統(tǒng)計(jì)學(xué)意義(P=0.003)。單因素分析顯示:原發(fā)灶大小、肝功能Child-Pugh分級(jí)、白蛋白、總膽紅素、膽堿酯酶、NLR是影響HCC患者氬氦冷凍消融術(shù)后生存期的相關(guān)因素(P0.05)。多因素分析顯示:原發(fā)灶大小和NLR是影響HCC患者氬氦冷凍消融術(shù)后生存的獨(dú)立預(yù)后因素(P0.05)。結(jié)論術(shù)前外周血中NLR可作為HCC患者行氬氦冷凍消融術(shù)的預(yù)后指標(biāo),肝內(nèi)原發(fā)灶越大、NLR越高,患者預(yù)后越差。
[Abstract]:Objective to investigate the effect of peripheral blood neutrophils / lymphocytes ratio (neutrophil to lymphocyte ratio,NLR) on prognosis in patients with primary liver cancer (HCC) before argon-he cryoablation. Methods the clinicopathological data of 72 patients with HCC undergoing percutaneous argon-he cryoablation were analyzed retrospectively. According to the preoperative NLR, the patients were divided into low NLR group (NLR3.5) and high NLR group (NLR 鈮，

本文編號(hào)：2511691