【摘要】：乳腺癌中國女性最常見的惡性腫瘤,近年來其發(fā)病率和死亡率呈明顯上升趨勢。ALND在乳腺癌的外科治療中占有重要的地位,但卻帶來了上肢淋巴水腫、疼痛、麻木及肩關(guān)節(jié)運(yùn)動障礙等術(shù)后并發(fā)癥。前哨淋巴結(jié)活檢SLNB能較為準(zhǔn)確地預(yù)測腋窩淋巴結(jié)狀態(tài),使SLN陰性乳腺癌患者免于ALND,減少了手術(shù)創(chuàng)傷,提高了患者術(shù)后生活質(zhì)量。SLNB的效果在很大程度上取決于示蹤方式以及示蹤劑的選擇,尋找示蹤效果好且安全性高的示蹤劑至關(guān)重要。目的:評價納米炭與亞甲藍(lán)作為乳腺癌前哨淋巴結(jié)示蹤劑的可行性。方法:選擇2012年10月～2013年9月在我院住院治療的女性早期乳腺癌患者共160例,術(shù)前均行同位素標(biāo)記,分兩組各80例分別使用亞甲藍(lán)與納米炭作為示蹤劑行術(shù)中前哨淋巴結(jié)活檢,觀測并記錄同位素法與兩種染料法的前哨淋巴結(jié)檢出情況。結(jié)果:亞甲藍(lán)組前哨淋巴結(jié)檢出率為86.25%(69/80),納米炭組前哨淋巴結(jié)檢出率為93.25%(77/80),后者明顯高于前者(P0.05),準(zhǔn)確率、假陰性率與敏感性兩組間差異無統(tǒng)計學(xué)意義(均P0.05)。結(jié)論:兩種染料均可作為前哨淋巴結(jié)的安全示蹤劑,納米炭法檢出率優(yōu)于亞甲藍(lán)法。
[Abstract]:The most common malignant tumor in Chinese women with breast cancer has shown an increasing trend in incidence and mortality in recent years. ALND plays an important role in the surgical treatment of breast cancer, but it brings postoperative complications such as upper limb lymphoedema, pain, numbness and shoulder joint motion disorder. Sentinel lymph node biopsies can accurately predict axillary lymph node status, make patients with SLN negative breast cancer free from ALND, and improve the quality of life of patients after operation. The effect of SLNB depends to a large extent on the tracer mode and the choice of tracer, so it is very important to find a tracer with good tracer effect and high safety. Objective: to evaluate the feasibility of nano-carbon and methylene blue as sentinel lymph node tracer for breast cancer. Methods: 160 female patients with early breast cancer who were hospitalized in our hospital from October 2012 to September 2013 were treated with isotopic labeling before operation. 80 patients in each group were treated with methylene blue and carbon nanoparticles as tracers for sentinel lymph node biopsy. the sentinel lymph nodes detected by isotope method and dye method were observed and recorded. Results: the detection rate of sentinel lymph nodes in methylene blue group was 86.25% (69 鈮，

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