【摘要】：目的提高對原發(fā)性氣管支氣管淋巴瘤的認(rèn)識。方法回顧性分析本院2013年和2015年收治的2例原發(fā)性氣管支氣管淋巴瘤患者的臨床資料并進行相關(guān)文獻(xiàn)復(fù)習(xí)。以"氣管淋巴瘤"或"支氣管淋巴瘤"為檢索詞檢索中國期刊網(wǎng)全文數(shù)據(jù)庫、萬方數(shù)據(jù)庫及維普數(shù)據(jù)庫,以"Trachea"OR"Bronchus"AND"Lymphoma"為檢索詞檢索Pub Med、Ovid Medline及Embase數(shù)據(jù)庫,共檢索到72例原發(fā)于初級支氣管,并沒有胸腔外淋巴瘤依據(jù)的原發(fā)性氣管支氣管淋巴瘤。對患者的臨床、影像學(xué)、病理組織學(xué)特點、治療及預(yù)后進行總結(jié)。結(jié)果本院收治的2例原發(fā)性氣管支氣管淋巴瘤患者均為女性,以"咳嗽、呼吸困難"為主訴就診,經(jīng)纖維支氣管鏡活檢診斷為B細(xì)胞淋巴瘤1例,套細(xì)胞淋巴瘤1例。經(jīng)化療后,患者癥狀明顯緩解,隨訪至2016年10月病情未復(fù)發(fā)。文獻(xiàn)復(fù)習(xí)發(fā)現(xiàn)原發(fā)氣管支氣管淋巴瘤病發(fā)病年齡為16~82歲,中位年齡51歲,也可見于年輕人,發(fā)病年齡16~30歲9例(12.50%);女性居多(47例,占65.28%)。主要癥狀為呼吸困難和咳嗽,肺功能提示阻塞性通氣功能障礙,胸部CT可見氣管或支氣管內(nèi)結(jié)節(jié)影伴或不伴肺不張,支氣管鏡下可見腫物,病理類型以黏膜相關(guān)淋巴組織(MALT)淋巴瘤最常見(36.11%)。套細(xì)胞淋巴瘤目前尚未見報道。結(jié)論原發(fā)性氣管支氣管淋巴瘤是較少見的氣管腫瘤之一,其臨床表現(xiàn)、影像學(xué)和支氣管鏡下表現(xiàn)并無特異性,易與肺癌混淆,可出現(xiàn)危及生命的呼吸道梗阻。支氣管鏡檢查對該病診斷有較大價值,確診需依賴組織病理學(xué)檢查。最常見病理類型為MALT淋巴瘤,其預(yù)后較好。
[Abstract]:Objective to improve the understanding of primary tracheobronchial lymphoma. Methods the clinical data of 2 patients with primary tracheobronchial lymphoma treated in our hospital in 2013 and 2015 were analyzed retrospectively and the related literature was reviewed. The full-text database of Chinese journal network, Wanfang database and VIP database were searched with "trachea OR" or "bronchial lymphoma" as search words, and "Trachea" OR "Bronchus" AND "Lymphoma" were used as search words to search Pub Med,Ovid Medline and Embase databases. A total of 72 cases of primary tracheobronchial lymphomas with primary bronchus originated in primary bronchus and no extrathoracic lymphomas were searched. The clinical, imaging, pathological characteristics, treatment and prognosis of the patients were summarized. Results two cases of primary tracheobronchial lymphomas were treated in our hospital. "cough, dyspnea" were the main complaints. 1 case of B-cell lymphomas and 1 case of sleeve-cell lymphomas were diagnosed by fiberoptic bronchoscopy. After chemotherapy, the symptoms of the patients were significantly relieved and no recurrence was found until October 2016. Literature review showed that the age of primary tracheobronchial lymphomatosis was 16 鈮，

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