【摘要】：目的探究保肝藥在急性髓系白血病(AML)患者化療中預(yù)防肝損傷發(fā)生的臨床意義。方法回顧性分析某三甲醫(yī)院血液科2012年1月至2015年12月接受IA方案治療的128例初診AML患者使用肝病輔助治療藥(保肝藥)預(yù)防肝損傷發(fā)生的情況。128例病例中使用保肝藥物預(yù)防的試驗(yàn)組99例,未使用保肝藥物預(yù)防的對(duì)照組29例,試驗(yàn)組又包含谷胱甘肽預(yù)防組、異甘草酸鎂預(yù)防組、谷胱甘肽合并異甘草酸鎂預(yù)防組以及其他組。試驗(yàn)組在初次誘導(dǎo)化療的同時(shí)使用保肝藥物;對(duì)照組僅接受化療,并記錄兩組患者化療前后的肝功能生化指標(biāo)。結(jié)果試驗(yàn)組肝損傷發(fā)生率和對(duì)照組相比無顯著性差異(P0.05),三組保肝藥之間的預(yù)防效果無顯著性差異(P0.05),經(jīng)Cox回歸對(duì)肝損傷發(fā)生的相關(guān)因素分析,無顯著性差異(P0.05)。結(jié)論預(yù)防性使用保肝藥物并未減少接受IA方案化療的初治AML患者的肝損傷的發(fā)生。
[Abstract]:Objective to investigate the clinical significance of hepatoprotective drugs in preventing liver injury in patients with acute myeloid leukemia (AML). Methods A retrospective analysis was made on the prevention of liver injury in 128 newly diagnosed AML patients treated with IA regimen from January 2012 to December 2015 in the Department of Hematology, a third grade A hospital. 99 patients in the experimental group were prevented with hepatoprotective drugs. There were 29 patients in the control group who did not use hepatoprotective drugs. The experimental group included glutathione prevention group, magnesium isoglycyrrhizinate prevention group, glutathion combined with magnesium isoglycyrrhizinate prevention group and other groups. The experimental group was treated with hepatoprotective drugs at the same time as the first induction chemotherapy, while the control group was only treated with chemotherapy, and the biochemical indexes of liver function before and after chemotherapy were recorded. Results there was no significant difference in the incidence of liver injury between the experimental group and the control group (P 0.05). There was no significant difference in the preventive effect among the three groups (P 0.05). The related factors of liver injury were analyzed by Cox regression. There was no significant difference (P 0.05). Conclusion Preventive use of hepatoprotective drugs does not reduce the incidence of liver injury in patients with AML who receive IA regimen chemotherapy.
【作者單位】： 北京大學(xué)人民醫(yī)院藥劑科;北京大學(xué)藥學(xué)院藥事管理與臨床藥學(xué)系;北京大學(xué)人民醫(yī)院血液科;
【分類號(hào)】：R733.71

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