【摘要】：目的:通過對(duì)50例應(yīng)用紫杉醇+順鉑方案化療的腫瘤患者進(jìn)行中藥外敷臍貼治療,觀察中藥外敷臍貼輔助鹽酸帕洛諾司瓊注射液、地塞米松磷酸鈉注射液治療含順鉑方案化療引起的胃腸道反應(yīng)的療效,評(píng)價(jià)其對(duì)胃腸道不良反應(yīng)的緩解和控制情況,從而為中藥外敷臍貼輔助治療含順鉑方案化療引起的胃腸道反應(yīng)的臨床研究,提供進(jìn)一步的支持和參考。方法:按照納入標(biāo)準(zhǔn)和排除標(biāo)準(zhǔn),收集了2016年1月至2016年12月于山東中醫(yī)藥大學(xué)附屬醫(yī)院腫瘤科住院,并予紫杉醇+順鉑方案化療的患者50例。將入選病例按照隨機(jī)數(shù)表法分為觀察組和對(duì)照組,每組各25例。對(duì)照組僅予鹽酸帕洛諾司瓊注射液和地塞米松磷酸鈉注射液;觀察組在對(duì)照組的基礎(chǔ)上,予中藥外敷臍貼治療。觀察治療后兩組患者胃腸道不良反應(yīng)的分級(jí)情況,綜合評(píng)價(jià)中藥外敷臍貼輔助鹽酸帕洛諾司瓊注射液和地塞米松磷酸鈉注射液,治療含順鉑方案化療引起的胃腸道反應(yīng)的療效及安全性。結(jié)果:觀察組25例患者中,嘔吐發(fā)生率為28%,腹脹發(fā)生率為36%,便秘發(fā)生率為36%;對(duì)照組25例患者中,嘔吐發(fā)生率為68%,腹脹發(fā)生率為92%,便秘發(fā)生率為80%。兩組結(jié)果的差異具有顯著性的意義(PO.05),觀察組的治療效果優(yōu)于對(duì)照組。兩組患者治療后,在嘔吐、腹脹、便秘等中醫(yī)癥狀分級(jí)量化的比較上也有顯著性的意義(PO.05),觀察組的治療效果優(yōu)于對(duì)照組。結(jié)論:中藥外敷臍貼輔助鹽酸帕洛諾司瓊注射液和地塞米松磷酸鈉注射液,對(duì)含順鉑方案化療引起胃腸道反應(yīng)的治療效果,從嘔吐、腹脹、便秘方面比較,要明顯優(yōu)于單一使用鹽酸帕洛諾司瓊注射液和地塞米松磷酸鈉注射液,且方便易行、安全性高、效優(yōu)價(jià)廉。
[Abstract]:Objective: to observe 50 cases of tumor patients treated with paclitaxel cisplatin chemotherapy with external application of traditional Chinese medicine umbilical cord paste and paronosetron hydrochloride injection. The efficacy of dexamethasone sodium phosphate injection in the treatment of gastrointestinal reactions induced by cisplatin-containing chemotherapy was evaluated, and the relief and control of adverse reactions to gastrointestinal tract were evaluated. In order to provide further support and reference for the clinical study of external application of traditional Chinese medicine umbilical cord paste in the treatment of gastrointestinal reaction induced by chemotherapy with cisplatin-containing regimen. Methods: according to the inclusion criteria and exclusion criteria, 50 patients who were hospitalized in the Department of Oncology, affiliated Hospital of Shandong University of traditional Chinese Medicine from January 2016 to December 2016, were treated with paclitaxel cisplatin regimen. The patients were divided into observation group (n = 25) and control group (n = 25) according to random table method. The control group was treated only with parosetron hydrochloride injection and dexamethasone sodium phosphate injection, and the observation group was treated with external application of traditional Chinese medicine umbilical cord paste on the basis of the control group. To observe the grading of gastrointestinal adverse reactions in the two groups after treatment, and to evaluate the external application of traditional Chinese medicine in the treatment of umbilical cord paste assisted with parosetron hydrochloride injection and dexamethasone sodium phosphate injection. Efficacy and safety of chemotherapy-induced gastrointestinal reaction in patients with cisplatin-containing chemotherapy. Results: the incidence of vomiting, abdominal distension and constipation was 28%, 36% and 36% in the observation group and 68%, 92% and 80% in the control group, respectively. The difference between the two groups was significant (PO.05), and the therapeutic effect of the observation group was better than that of the control group. After treatment, there was significant difference (PO.05) between the two groups in the quantification of TCM symptoms, such as vomiting, abdominal distension and constipation, and the therapeutic effect of the observation group was better than that of the control group. Conclusion: the external application of traditional Chinese medicine navel paste in combination with paloxetron hydrochloride injection and dexamethasone sodium phosphate injection, in the treatment of gastrointestinal reaction induced by chemotherapy with cisplatin regimen, was compared in terms of vomiting, abdominal distension and constipation. It is superior to parosetron hydrochloride injection and dexamethasone sodium phosphate injection alone, and is convenient, safe, effective and cheap.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R730.53

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