天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

當(dāng)前位置:主頁 > 醫(yī)學(xué)論文 > 腫瘤論文 >

胃癌病理特征與HIF-1α和VEGF mRNA表達(dá)水平的關(guān)系

發(fā)布時間:2019-01-25 21:24
【摘要】:目的:探討胃癌病理特征與HIF-la和VEGF mRNA表達(dá)水平的關(guān)系方法:采集67例胃癌病人術(shù)前的胃鏡標(biāo)本,采用半定量RT-PCR的方法檢測胃癌組織及周圍正常組織中的HIF-la和VEGF mRNA的表達(dá)水平。HIF-1α和VEGF mRNA的表達(dá)水平的評價采用癌組織(tumor)和正常組織(normal)的增值比例來表示。同時對所有胃癌患者臨床病理特征進(jìn)行回顧性分析。結(jié)果:HIF-1α mRNA的表達(dá)中,癌組織高于正常組織,并其T/N值與胃癌的淋巴轉(zhuǎn)移、遠(yuǎn)處轉(zhuǎn)移、分期呈正相關(guān)(P0.05),與胃癌分化程度呈無統(tǒng)計學(xué)相關(guān)性(p0.05)。VEGF mRNA的表達(dá)同樣是癌組織高于正常組織,其T/N值與淋巴轉(zhuǎn)移和遠(yuǎn)處轉(zhuǎn)移呈正相關(guān)(P0.05),與胃癌分化程度呈無統(tǒng)計學(xué)相關(guān)性(p0.05)。結(jié)論:HIF-1α和VEGF mRNA表達(dá)水平越高的胃癌侵襲性越強。通過對胃癌的胃鏡活檢標(biāo)本行RT-PCR檢測HIF-1α和VEGF mRNA表達(dá)水平可以對胃癌的侵襲性進(jìn)行術(shù)前評估。
[Abstract]:Objective: to investigate the relationship between pathological features of gastric cancer and the expression of HIF-la and VEGF mRNA. The expression of HIF-la and VEGF mRNA in gastric carcinoma and surrounding normal tissues was detected by semi-quantitative RT-PCR, and the expression of HIF-1 偽 and VEGF mRNA was evaluated by the ratio of (tumor) and (normal). The clinicopathological features of all patients with gastric cancer were analyzed retrospectively. Results: the expression of HIF-1 偽 mRNA in cancer tissue was higher than that in normal tissue, and the T / N value was positively correlated with lymph node metastasis, distant metastasis and staging of gastric cancer (P0.05). There was no significant correlation between the expression of p0. 05). VEGF mRNA and the degree of differentiation of gastric cancer (p0. 05). VEGF mRNA expression was higher than that of normal tissue, and the T / N value was positively correlated with lymphatic metastasis and distant metastasis (P0.05). There was no statistical correlation with the differentiation of gastric cancer (p0.05). Conclusion: the higher the expression of HIF-1 偽 and VEGF mRNA, the stronger the invasion of gastric cancer. The expression of HIF-1 偽 and VEGF mRNA in gastric cancer specimens were detected by RT-PCR, and the invasiveness of gastric cancer could be evaluated before operation.
【學(xué)位授予單位】:山東大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2015
【分類號】:R735.2

【二級參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 郭鳳嬋;劉福虹;;缺氧誘導(dǎo)因子-1α、血管內(nèi)皮因子與宮頸癌血管生成的關(guān)系[J];河北醫(yī)藥;2007年04期

,

本文編號:2415205

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/zlx/2415205.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶b8d3e***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
久久国产成人精品国产成人亚洲| 欧美乱视频一区二区三区| 国产精品一区二区三区黄色片| 99久久精品一区二区国产| 久久精品亚洲精品一区| 亚洲中文字幕人妻av| 国产av一区二区三区久久不卡| 国产免费成人激情视频| 男女午夜福利院在线观看| 国产又色又爽又黄又免费| 大屁股肥臀熟女一区二区视频| 青青草草免费在线视频| 极品少妇嫩草视频在线观看| 老鸭窝精彩从这里蔓延| 插进她的身体里在线观看骚| 久久精品国产一区久久久| 中文字幕人妻日本一区二区| 国产乱人伦精品一区二区三区四区 | 大香伊蕉欧美一区二区三区| 国产主播精品福利午夜二区| 日本福利写真在线观看| 国产精品午夜一区二区三区| 国产日韩欧美在线亚洲| 国产亚洲欧美自拍中文自拍| 不卡一区二区在线视频| 91日韩欧美中文字幕| 99精品人妻少妇一区二区人人妻 | 日韩一级毛一欧美一级乱| 亚洲伦片免费偷拍一区| 日韩国产亚洲欧美激情| 不卡中文字幕在线免费看| 日韩欧美三级中文字幕| 殴美女美女大码性淫生活在线播放| 亚洲av熟女国产一区二区三区站| 又色又爽又无遮挡的视频| 精品人妻久久一品二品三品| 天堂热东京热男人天堂| 亚洲专区一区中文字幕| 精品国产亚洲av成人一区| 亚洲清纯一区二区三区| 日韩毛片视频免费观看|