天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

當(dāng)前位置:主頁 > 醫(yī)學(xué)論文 > 腫瘤論文 >

胃癌病理特征與HIF-1α和VEGF mRNA表達(dá)水平的關(guān)系

發(fā)布時間:2019-01-25 21:24
【摘要】:目的:探討胃癌病理特征與HIF-la和VEGF mRNA表達(dá)水平的關(guān)系方法:采集67例胃癌病人術(shù)前的胃鏡標(biāo)本,采用半定量RT-PCR的方法檢測胃癌組織及周圍正常組織中的HIF-la和VEGF mRNA的表達(dá)水平。HIF-1α和VEGF mRNA的表達(dá)水平的評價采用癌組織(tumor)和正常組織(normal)的增值比例來表示。同時對所有胃癌患者臨床病理特征進(jìn)行回顧性分析。結(jié)果:HIF-1α mRNA的表達(dá)中,癌組織高于正常組織,并其T/N值與胃癌的淋巴轉(zhuǎn)移、遠(yuǎn)處轉(zhuǎn)移、分期呈正相關(guān)(P0.05),與胃癌分化程度呈無統(tǒng)計學(xué)相關(guān)性(p0.05)。VEGF mRNA的表達(dá)同樣是癌組織高于正常組織,其T/N值與淋巴轉(zhuǎn)移和遠(yuǎn)處轉(zhuǎn)移呈正相關(guān)(P0.05),與胃癌分化程度呈無統(tǒng)計學(xué)相關(guān)性(p0.05)。結(jié)論:HIF-1α和VEGF mRNA表達(dá)水平越高的胃癌侵襲性越強。通過對胃癌的胃鏡活檢標(biāo)本行RT-PCR檢測HIF-1α和VEGF mRNA表達(dá)水平可以對胃癌的侵襲性進(jìn)行術(shù)前評估。
[Abstract]:Objective: to investigate the relationship between pathological features of gastric cancer and the expression of HIF-la and VEGF mRNA. The expression of HIF-la and VEGF mRNA in gastric carcinoma and surrounding normal tissues was detected by semi-quantitative RT-PCR, and the expression of HIF-1 偽 and VEGF mRNA was evaluated by the ratio of (tumor) and (normal). The clinicopathological features of all patients with gastric cancer were analyzed retrospectively. Results: the expression of HIF-1 偽 mRNA in cancer tissue was higher than that in normal tissue, and the T / N value was positively correlated with lymph node metastasis, distant metastasis and staging of gastric cancer (P0.05). There was no significant correlation between the expression of p0. 05). VEGF mRNA and the degree of differentiation of gastric cancer (p0. 05). VEGF mRNA expression was higher than that of normal tissue, and the T / N value was positively correlated with lymphatic metastasis and distant metastasis (P0.05). There was no statistical correlation with the differentiation of gastric cancer (p0.05). Conclusion: the higher the expression of HIF-1 偽 and VEGF mRNA, the stronger the invasion of gastric cancer. The expression of HIF-1 偽 and VEGF mRNA in gastric cancer specimens were detected by RT-PCR, and the invasiveness of gastric cancer could be evaluated before operation.
【學(xué)位授予單位】:山東大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2015
【分類號】:R735.2

【二級參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 郭鳳嬋;劉福虹;;缺氧誘導(dǎo)因子-1α、血管內(nèi)皮因子與宮頸癌血管生成的關(guān)系[J];河北醫(yī)藥;2007年04期

,

本文編號:2415205

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/zlx/2415205.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶b8d3e***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
国产亚州欧美一区二区| 黄色污污在线免费观看| 四季av一区二区播放| 国产肥女老熟女激情视频一区| 国产亚洲视频香蕉一区| 久久精品欧美一区二区三不卡| 欧美日韩免费观看视频| 超碰在线免费公开中国黄片| 国产中文另类天堂二区| 欧美黑人巨大一区二区三区| 精品老司机视频在线观看| 亚洲一区二区三区免费的视频| 欧美性高清一区二区三区视频| 午夜精品黄片在线播放| 久久精品国产亚洲熟女| 亚洲一区二区亚洲日本| 五月婷婷欧美中文字幕| 午夜精品一区二区三区国产| 亚洲综合精品天堂夜夜| 成人区人妻精品一区二区三区| 国产亚洲中文日韩欧美综合网| 国产毛片av一区二区三区小说| 一级欧美一级欧美在线播| 国产亚洲精品岁国产微拍精品| 久久经典一区二区三区| 亚洲一级在线免费观看| 丁香六月啪啪激情综合区| 国产一区二区三区口爆在线| 日韩毛片视频免费观看| 日本不卡视频在线观看| 嫩草国产福利视频一区二区| 久久精品中文字幕人妻中文| 日韩特级黄色大片在线观看| 国产午夜精品福利免费不| 久久精视频免费视频观看| 在线欧美精品二区三区| 免费在线观看激情小视频| 欧美高潮喷吹一区二区| 亚洲欧美日本国产不卡| 亚洲天堂国产精品久久精品| 欧美激情一区=区三区|