【摘要】：目的:觀察s IL-2R、VEGF在分化型甲狀腺癌患者血清中的表達(dá)水平,探討血清s IL-2R、VEGF與分化型甲狀腺癌在發(fā)生、發(fā)展之間的關(guān)系,從而為甲狀腺惡性腫瘤的早期診斷、嚴(yán)重程度、手術(shù)治療方案及預(yù)后評(píng)價(jià)提供依據(jù)。方法:收集2014年5月至2015年2月于我省腫瘤醫(yī)院頭頸外科因甲狀腺腫瘤住院患者的空腹血清標(biāo)本33例,經(jīng)手術(shù)后確診,其中甲狀腺良性腫瘤組14例,分化型甲狀腺癌組19例,分別用酶聯(lián)免疫分析(ELISA)方法測(cè)定血清中s IL-2R、VEGF濃度,并與19例健康人對(duì)照進(jìn)行比較。結(jié)果:1.三組標(biāo)本血清中s IL-2R含量比較,分化型甲狀腺癌組分別高于甲狀腺良性腫瘤組及健康人組,差異有統(tǒng)計(jì)學(xué)意義(P0.001),甲狀腺良性腫瘤組高于健康人組,差異有統(tǒng)計(jì)學(xué)意義(P0.001)。2.三組標(biāo)本血清中VEGF濃度比較,分化型甲狀腺癌組分別高于甲狀腺良性腫瘤組及健康人組,差異有統(tǒng)計(jì)學(xué)意義(P0.001),甲狀腺良性腫瘤組高于健康人組,差異有統(tǒng)計(jì)學(xué)意義(P0.001)。3.不同病理類型的分化型甲狀腺癌之間血清s IL-2R、VEGF濃度比較,無統(tǒng)計(jì)學(xué)意義。4.分化型甲狀腺癌組中不同性別、不同年齡(40,≥40)之間兩項(xiàng)指標(biāo)比較無統(tǒng)計(jì)學(xué)差異。結(jié)論:1.分化型甲狀腺癌患者血清s IL-2R、VEGF表達(dá)水平均高于甲狀腺良性腫瘤患者和健康人,此指標(biāo)可作為甲狀腺良、惡性腫瘤鑒別參考指標(biāo)之一。2.甲狀腺良性腫瘤患者血清s IL-2R、VEGF表達(dá)均高于健康人,此指標(biāo)可用于幫助診斷早期甲狀腺病變。3.尚不能認(rèn)為血清s IL-2R、VEGF濃度與分化型甲狀腺癌的病理類型有關(guān)。4.尚不能認(rèn)為分化型甲狀腺癌患者血清s IL-2R、VEGF表達(dá)水平與年齡、性別有關(guān)。
[Abstract]:Objective: to observe the expression of s IL-2R,VEGF in serum of patients with differentiated thyroid carcinoma, and to explore the relationship between serum s IL-2R,VEGF and the occurrence and development of differentiated thyroid carcinoma. Severity, surgical treatment and prognostic evaluation provide evidence. Methods: from May 2014 to February 2015, the fasting serum samples of 33 patients with thyroid neoplasms in head and neck surgery department of our province tumor hospital were collected. After operation, there were 14 cases of benign thyroid tumor and 19 cases of differentiated thyroid carcinoma. Serum s IL-2R,VEGF levels were measured by Elisa (ELISA) method and compared with 19 healthy controls. Results: 1. The levels of serum s IL-2R in differentiated thyroid carcinoma group were higher than those in benign thyroid tumor group and healthy person group (P0. 001), and the level of s IL-2R in thyroid benign tumor group was higher than that in healthy person group (P0. 001). The difference was statistically significant (P0.001). The levels of serum VEGF in differentiated thyroid carcinoma group were higher than those in benign thyroid tumor group and healthy person group (P0. 001), and the level of VEGF in thyroid benign tumor group was higher than that in healthy person group (P0. 001). The difference was statistically significant (P0.001). There was no significant difference in serum s IL-2R,VEGF levels between differentiated thyroid carcinomas with different pathological types. 4. There was no significant difference between sex and age (40, 鈮，

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