【摘要】：目的:探討表皮生長因子受體(epidermal growth factor receptor,EGFR)和磷酸化表皮生長因子受體(phosphorylated epidermal growth factor receptor,P-EGFR)在食管鱗狀細胞癌(esophageal squamous cell carcinoma,ESCC,食管鱗癌)中的表達與其臨床病理特征的相關性及預后的關系。方法:采用免疫組織化學方法(immunohistochemistry,IHC)檢測100例食管鱗癌患者癌組織及癌旁組織中EGFR和P-EGFR的表達水平,分析食管鱗癌組織中EGFR和P-EGFR的表達水平與食管鱗癌患者臨床病理特征及預后的關系。結果:(1)EGFR在食管鱗癌組織和癌旁組織中的陽性表達率分別為72%(72/100)、17%(17/100),二者相比差異具有統(tǒng)計學意義(χ2=75.531,P0.01);P-EGFR在食管鱗癌及其癌旁組織中的陽性表達率分別為64%(64/100)、12%(12/100),兩者相比差異有統(tǒng)計學意義(χ2=74.123,P0.01)。(2)EGFR蛋白陽性表達水平與食管鱗癌患者的分化程度、pT分期及淋巴結轉移有關(均P0.05),但與性別、年齡、pTNM分期均無關(均P0.05);P-EGFR蛋白的表達水平與食管鱗癌患者的分化程度有關(P0.05),而與性別、年齡、pT分期、pN分期、pTNM分期均無關(均P0.05)。此外,EGFR與P-EGFR蛋白陽性表達呈正相關。(3)Kaplan-Meier生存分析顯示與EGFR和P-EGFR高表達者相比,EGFR與P-EGFR低表達患者總生存期及無病生存期均優(yōu)于高表達者(均P0.05)。結論:EGFR和P-EGFR的表達水平的高低與患者總生存期及無病生存期均存在顯著相關性,提示可能是預測食管鱗癌患者預后的預測因子。
[Abstract]:Objective: to investigate the role of epidermal growth factor receptor (epidermal growth factor receptor,EGFR) and phosphorylated epidermal growth factor receptor (phosphorylated epidermal growth factor receptor,P-EGFR) in esophageal squamous cell carcinoma (esophageal squamous cell carcinoma,ESCC,). The relationship between expression and clinicopathological features and prognosis of esophageal squamous cell carcinoma. Methods: immunohistochemical method (immunohistochemistry,IHC) was used to detect the expression of EGFR and P-EGFR in carcinoma tissues and adjacent tissues of 100 patients with esophageal squamous cell carcinoma. To analyze the relationship between the expression of EGFR and P-EGFR in esophageal squamous cell carcinoma and the clinicopathological features and prognosis of esophageal squamous cell carcinoma. Results: (1) the positive expression rates of EGFR in esophageal squamous cell carcinoma and paracancerous tissues were 72% (72 / 100) and 17% (17 / 100), respectively. The positive expression rates of P-EGFR in esophageal squamous cell carcinoma and its adjacent tissues were 64% (64 / 100) and 12% (12 / 100), respectively. The positive expression of EGFR protein was related to the differentiation degree, pT stage and lymph node metastasis of esophageal squamous cell carcinoma (P0.01). (2) (P0.05), but not to sex, age and pTNM stage (P0.05). The expression of P-EGFR protein was related to the differentiation of esophageal squamous cell carcinoma (P0.05), but not to sex, age, pT stage, pN stage and pTNM stage (P0.05). In addition, there was a positive correlation between the expression of EGFR and P-EGFR protein. (3) Kaplan-Meier survival analysis showed that the positive expression of EGFR and P-EGFR was higher than that of EGFR. The total survival time and disease-free survival of patients with low expression of EGFR and P-EGFR were better than those with high expression (P0.05). Conclusion: the expression of EGFR and P-EGFR is significantly correlated with the total survival and disease-free survival, suggesting that the expression of EGFR and P-EGFR may be a predictor of prognosis in patients with esophageal squamous cell carcinoma.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R735.1

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