【摘要】：前列腺癌發(fā)病率高,起病隱匿,潛伏期長,出現(xiàn)癥狀時(shí)往往已伴有局部浸潤或遠(yuǎn)處轉(zhuǎn)移,早期診斷和治療能有效降低前列腺癌患者的死亡率。在早期診斷方面,直腸指檢和前列腺特異性抗原提高了前列腺癌診斷的敏感性,但其低特異性也造成了大量的過度醫(yī)療;在治療方面,前列腺癌根治術(shù)輔以內(nèi)分泌治療對(duì)前列腺癌有一定的療效,但絕大多數(shù)患者最終進(jìn)展為去勢(shì)抵抗性前列腺癌,從而嚴(yán)重影響患者的生存期。近年來,前列腺癌腫瘤標(biāo)志物和影像學(xué)技術(shù)成為人們研究的熱點(diǎn),并取得了重大進(jìn)展,顯著提高前列腺癌早期診斷的準(zhǔn)確率,為腫瘤預(yù)后評(píng)估提供了重要依據(jù)。同時(shí)前列腺癌新型藥物的研制亦取得了前所未有的進(jìn)展,多種靶向治療藥物及免疫治療藥物逐步問世。本文就前列腺癌最新診斷和治療進(jìn)展作一綜述。
[Abstract]:The incidence of prostate cancer is high, the onset is hidden, the incubation period is long, and the symptoms are often accompanied by local infiltration or distant metastasis. Early diagnosis and treatment can effectively reduce the mortality of patients with prostate cancer. In early diagnosis, rectal finger examination and prostate specific antigen increased the sensitivity of prostate cancer diagnosis, but its low specificity also resulted in a large amount of overtreatment; in treatment, Radical prostatectomy combined with endocrine therapy has a certain curative effect on prostate cancer, but the majority of patients eventually progress to castration resistant prostate cancer, which seriously affects the survival time of the patients. In recent years, tumor markers and imaging techniques of prostate cancer have become the focus of research, and great progress has been made. The accuracy of early diagnosis of prostate cancer has been significantly improved, which provides an important basis for the evaluation of tumor prognosis. At the same time, the development of new prostatic cancer drugs has made unprecedented progress. This article reviews the latest diagnosis and treatment of prostate cancer.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R737.25

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本文編號(hào)：2277051