發(fā)布時(shí)間：2018-09-06 06:37

【摘要】：目的:觀察奧沙利鉑治療結(jié)直腸癌所致神經(jīng)毒性的發(fā)生情況,對(duì)導(dǎo)致神經(jīng)毒性的相關(guān)高危因素進(jìn)行分析,為神經(jīng)毒性的預(yù)防提供參考意見。方法:對(duì)109例接受奧沙利鉑化療的結(jié)直腸癌患者的病例進(jìn)行回顧性分析,記錄患者神經(jīng)毒性的發(fā)生情況及患者機(jī)體指標(biāo)、化療相關(guān)指標(biāo)、血常規(guī)、血生化相關(guān)檢驗(yàn)指標(biāo),用統(tǒng)計(jì)學(xué)方法篩選出導(dǎo)致神經(jīng)毒性的高危因素。結(jié)果:全部109例患者中,共有84例患者在接受奧沙利鉑治療后出現(xiàn)神經(jīng)毒性,總體發(fā)生率為77.1%,具體分析各項(xiàng)指標(biāo),發(fā)現(xiàn)患者的腫瘤分期、體表面積、化療周期數(shù)、奧沙利鉑累積劑量、化療后血小板的變化、化療后血鈣的變化等6項(xiàng)指標(biāo)有統(tǒng)計(jì)學(xué)意義(P0.05),是導(dǎo)致神經(jīng)毒性的高危因素。結(jié)論:奧沙利鉑治療結(jié)直腸癌過(guò)程中,神經(jīng)毒性發(fā)生率較高,對(duì)于合并相關(guān)高危因素的患者應(yīng)給予重視,密切觀察患者發(fā)生神經(jīng)毒性的情況,必要時(shí)給予積極預(yù)防及治療措施。
[Abstract]:Aim: to observe the occurrence of neurotoxicity induced by oxaliplatin in the treatment of colorectal cancer and to analyze the related high risk factors of neurotoxicity in order to provide reference for the prevention of neurotoxicity. Methods: 109 patients with colorectal cancer received oxaliplatin chemotherapy were retrospectively analyzed. High risk factors for neurotoxicity were screened by statistical method. Results: of the 109 patients, 84 had neurotoxicity after oxaliplatin treatment, and the overall incidence was 77.1. The tumor stage, body surface area and the number of chemotherapy cycles were found by specific analysis. The cumulative dose of oxaliplatin the changes of platelets after chemotherapy and the changes of blood calcium after chemotherapy were statistically significant (P0.05) which were the high risk factors leading to neurotoxicity. Conclusion: the incidence of neurotoxicity in the treatment of colorectal cancer with oxaliplatin is high. Attention should be paid to the patients with associated high risk factors. The neurotoxicity of patients should be observed closely and preventive and therapeutic measures should be taken if necessary.
【學(xué)位授予單位】：皖南醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R735.34

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