【摘要】：目的:旨在使用Meta分析方法系統(tǒng)評價八聚體結合轉錄因子4(octamer-binding transcription factor 4,OCT4)表達與非小細胞肺癌(non-small cell lung cancer,NSCLC)臨床病理特征的關系。方法:電子檢索Pub Med、Embase、中國生物醫(yī)學文獻數(shù)據(jù)庫、中國學術期刊全文數(shù)據(jù)庫、維普中文科技核心全文數(shù)據(jù)庫以及萬方數(shù)據(jù)庫,檢索時間從建庫至2016年3月,查找涉及OCT4表達與NSCLC臨床病理特征相關的病例對照研究。參照Cochrane協(xié)作網(wǎng)推薦的方法進行篩選及提取數(shù)據(jù)并評價納入研究的質量,運用Revman 5.2軟件及Stata 12.0軟件進行Meta分析。結果:共納入10個研究,905例患者。OCT4陽性組471例,OCT4陰性組434例。Meta分析結果顯示,OCT4陽性表達與肺腺癌(OR=1.75,95%CI=1.22~2.53,P=0.003)、低分化癌(OR=2.93,95%CI=1.25~6.84,P=0.010)、中分化癌(OR=1.81,95%CI=1.12~2.94,P=0.020)、T3/T4期腫瘤(OR=1.95,95%CI=1.10~3.45,P=0.020)、術后生存期短(鱗癌:MD=-4.49,95%CI=-7.73~-1.55,P=0.003;腺癌:MD=-8.52,95%CI=-9.82~-7.23,P=0.000)及總體生存率低下(HR=1.99,95%CI=1.52~2.60)關系較為密切,差異均具有統(tǒng)計學意義。結論:OCT4陽性表達與肺腺癌、NSCLC惡性特征以及預后不良密切相關,可以為肺癌靶向治療提供可靠的科學依據(jù)。
[Abstract]:Objective: to evaluate the relationship between the expression of octamer binding transcription factor 4 (octamer-binding transcription factor 4) and clinicopathological features of non-small cell lung cancer (non-small cell lung cancer,NSCLC) by Meta assay. Methods: Pub Med,Embase, Chinese biomedical literature database, Chinese academic journal full-text database, Weipu Chinese science and technology core full-text database and Wanfang database were searched electronically. The retrieval time was from the establishment of the database to March 2016. A case-control study involving the expression of OCT4 and the clinicopathological features of NSCLC was found. According to the method recommended by Cochrane Cooperative Network, the data were screened and extracted, and the quality of the study was evaluated. The Meta analysis was carried out with Revman 5.2 software and Stata 12.0 software. 緇撴灉:鍏辯撼鍏，

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