【摘要】：隨著目前癌癥患者的急劇增加,放療、化療是臨床治療腫瘤的主要手段,其中,化療殺傷患者體內殘余腫瘤細胞,可提高療效,改善預后。但其不良反應——骨髓抑制,往往是造成患者不能按時足量完成化療,或導致患者發(fā)生嚴重感染而病死的重要原因。檢索近10年國內外有關骨髓抑制病理變化與治療的研究文獻,綜述放化療所致骨髓抑制的研究進展,明確放化療后骨髓抑制的人體各種病理變化與治療,綜合傳統(tǒng)中醫(yī)藥與現(xiàn)代醫(yī)學研究的放化療所致骨髓抑制的病理變化與治療,為治療骨髓抑制的藥物研究開發(fā)提供依據,針對于放化療后骨髓抑制的病理變化可以研制出新型的保髓生血藥物,也為其進一步治療骨髓抑制提供參考,并促進開發(fā)物質基礎清晰、作用機理明確、不良反應甚微的保髓生血天然藥物及其制劑。
[Abstract]:With the rapid increase of cancer patients, radiotherapy and chemotherapy are the main methods for clinical treatment of cancer. Among them, chemotherapy can kill the residual tumor cells of patients, which can improve the curative effect and improve the prognosis. However, the adverse reaction, bone marrow suppression, is often an important cause of the patient's failure to complete chemotherapy on time, or the death of the patient from serious infection. To review the recent 10 years' literatures on the pathological changes and treatment of bone marrow suppression, to review the progress in the study of bone marrow suppression induced by radiotherapy and chemotherapy, and to identify the various pathological changes and treatment of bone marrow suppression after radiotherapy and chemotherapy. The pathological changes and treatment of bone marrow suppression caused by radiotherapy and chemotherapy combined with traditional Chinese medicine and modern medical research provide the basis for the research and development of drugs for the treatment of bone marrow suppression. According to the pathological changes of bone marrow suppression after radiotherapy and chemotherapy, we can develop a new kind of medicine to preserve myelin and generate blood, and provide reference for further treatment of bone marrow suppression, and promote the development of clear material basis and clear mechanism of action. Natural drugs and their preparations for the preservation of myelin and blood with minimal adverse reactions.
【作者單位】： 成都中醫(yī)藥大學藥學院中藥材標準化教育部重點實驗室四川省中藥資源系統(tǒng)研究與開發(fā)利用重點實驗室(省部共建國家重點實驗室培育基地);江西中醫(yī)藥大學現(xiàn)代中藥制劑教育部重點實驗室;
【基金】：國家自然科學基金項目(No.81373976) 國家新藥創(chuàng)制重大專項項目(No.2013ZX09103002-013)~~
【分類號】：R730.5

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