【摘要】：背景與目的：肺癌是中國(guó)目前發(fā)病率及死亡率最高的惡性腫瘤之一,本研究旨在探討脈灌注化療與靜脈全身化療在中晚期非小細(xì)胞肺癌患者治療中的有效性及安全性。方法：計(jì)算機(jī)檢索PubMed、 Cochranelibrary、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(CBM)、中國(guó)知識(shí)資源總庫(kù)(CNKI)、萬(wàn)方數(shù)據(jù)在線知識(shí)服務(wù)平臺(tái),收集國(guó)內(nèi)外2000年-2014年間公開(kāi)發(fā)表的有關(guān)支氣管動(dòng)脈灌注化療與全身靜脈化療臨床對(duì)照試驗(yàn)的中英文文獻(xiàn),按照入選標(biāo)準(zhǔn)嚴(yán)格篩選文獻(xiàn)并對(duì)文獻(xiàn)質(zhì)量進(jìn)行評(píng)估,對(duì)最終入選的文獻(xiàn)使用RevMan5.0軟件進(jìn)行Meta分析。結(jié)果：納入分析的文獻(xiàn)共計(jì)11篇,Meta分析顯示支氣管灌注化療組有效率明顯高于全身靜脈化療組(RR,1.57; 95%CI,1.37-1.82; P0.001; 12=0%),但兩組患者1年生存率無(wú)統(tǒng)計(jì)學(xué)差異(RR,1.10; 95%CI,0.91-1.33;P=0.30;I2=24%)。支氣管動(dòng)脈灌注化療組血小板降低發(fā)生率顯著低于全身靜脈化療組(RR,0.64; 95%CI,0.30-1.37; P=0.006; 12=0%),但2組患者白細(xì)胞降低發(fā)生率無(wú)統(tǒng)計(jì)學(xué)差異(RR,0.77; 95%CI, 0.56-1.04; P=0.09; 12=87%),惡心、嘔吐發(fā)生率亦無(wú)統(tǒng)計(jì)學(xué)差異(RR, 0.64; 95%CI,0.30-1.37; P=0.25; I2=98%)。結(jié)論：支氣管動(dòng)脈化療對(duì)晚期非小細(xì)胞肺癌的有效率明顯高于全身靜脈化療,且在一定程度上能降低某些化療不良反應(yīng)的發(fā)生,可作為部分晚期非小細(xì)胞肺癌患者首選治療方式之一。
[Abstract]:Background & objective: lung cancer is one of the malignant tumors with the highest morbidity and mortality in China. The purpose of this study was to investigate the efficacy and safety of pulse infusion chemotherapy and intravenous systemic chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: the online knowledge service platform of PubMed, Cochranelibrary, (CBM), China knowledge Resource General Database (CNKI),) was searched by computer. To collect the Chinese and English literature on clinical controlled trials of bronchial artery infusion chemotherapy and systemic intravenous chemotherapy published at home and abroad from 2000 to 2014, and to screen the literature strictly according to the inclusion criteria and evaluate the quality of the literature. The final selected documents were analyzed by Meta using RevMan5.0 software. Results: a total of 11 meta-analysis papers showed that the effective rate of bronchial infusion chemotherapy group was significantly higher than that of systemic intravenous chemotherapy group (RRN 1.57; 95CII 1.37-1.82; P0.001; 120.0%), but there was no significant difference in 1-year survival rate between the two groups (RRN 1.10; 95 CI 0.91-1.33P0.30I224%). The incidence of thrombocytopenia in bronchial artery infusion chemotherapy group was significantly lower than that in systemic intravenous chemotherapy group (RRR 0.64; 95 CI 0.30-1.37; P0. 006; 120%), but there was no significant difference in the incidence of leukopenia between the two groups (RRR0. 77; 95CI0. 56-1. 04; P0. 09; 1287%), and there was no significant difference in the incidence of nausea and vomiting (RR0. 64; 95CIT 0. 30-1.37; P0. 25; I298%). Conclusion: the effective rate of bronchial arterial chemotherapy on advanced non-small cell lung cancer is significantly higher than that of systemic intravenous chemotherapy, and to some extent can reduce the occurrence of some adverse reactions. It can be used as one of the first treatment methods in patients with advanced non-small cell lung cancer (NSCLC).
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R734.2

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