天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

當(dāng)前位置:主頁 > 醫(yī)學(xué)論文 > 腫瘤論文 >

CD133在胃癌組織中的表達(dá)及其臨床意義的系統(tǒng)評價

發(fā)布時間:2018-07-08 08:56

  本文選題:胃癌 + CD133; 參考:《蘭州大學(xué)》2015年碩士論文


【摘要】:目的全面收集國內(nèi)外發(fā)表的相關(guān)研究,系統(tǒng)評價CD133蛋白表達(dá)與胃癌及其臨床病理學(xué)特征之間的關(guān)系,以了解CD133在胃癌發(fā)生、發(fā)展過程中的作用,以期為胃癌的治療和預(yù)后干預(yù)提供循證醫(yī)學(xué)依據(jù)。方法計算機(jī)檢索中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫、中文科技期刊全文數(shù)據(jù)庫、相關(guān)期刊論文、萬方數(shù)據(jù)庫、PubMed、EMbase、Web of Knowledge和The Cochrane Library,均從建庫檢索至2013年10月;并輔以手工檢索,查找國內(nèi)外公開發(fā)表的關(guān)于CD133蛋白表達(dá)與胃癌及其臨床病理特征相關(guān)性的病例-對照研究。由兩位研究者按照事先制定的納入排除標(biāo)準(zhǔn)篩選文獻(xiàn)、提取資料并評價方法學(xué)質(zhì)量后,采用RevMan 5.2軟件進(jìn)行Meta分析。使用STATA 11.0進(jìn)行Begg和Egger檢驗(yàn),并繪制Begg圖和Egger圖。最后,使用GRADEpro 3.6對各結(jié)果指標(biāo)進(jìn)行證據(jù)質(zhì)量分級。結(jié)果最終納入9個病例-對照研究,共623例患者。Meta分析結(jié)果顯示:CD133蛋白在胃癌組與癌旁和正常胃組織組[OR=3.89,95%CI (1.87,8.11),P=0.0003]、淋巴結(jié)轉(zhuǎn)移組與無淋巴結(jié)轉(zhuǎn)移組[OR=2.75,95%CI (1.99,3.81),P0.00001]、胃癌Ⅲ~Ⅳ期組與Ⅰ-Ⅱ期組[OR=2.83,95%CI (2.13,3.76),P0.00001]、伴遠(yuǎn)處轉(zhuǎn)移組與無遠(yuǎn)處轉(zhuǎn)移組[OR=2.38,95%CI (1.47,3.85),P=0.0004]的表達(dá)差異均有統(tǒng)計學(xué)意義。在高中分化組與低分化組的表達(dá)差異無統(tǒng)計學(xué)意義[OR=1.70,95%CI (0.90,3.21),p=0.10],但敏感性分析結(jié)果顯示該指標(biāo)Meta分析結(jié)果不穩(wěn)定,其他結(jié)果穩(wěn)定。發(fā)表偏倚檢測結(jié)果顯示本系統(tǒng)評價不存在發(fā)表偏倚。證據(jù)質(zhì)量分級結(jié)果顯示3個結(jié)果指標(biāo)為中等質(zhì)量,2個指標(biāo)為低質(zhì)量。結(jié)論CD133蛋白在胃癌組織中的表達(dá)比癌旁組織及正常胃組織高,而且其表達(dá)與淋巴結(jié)轉(zhuǎn)移、遠(yuǎn)處轉(zhuǎn)移及臨床分期等明顯相關(guān),說明CD133可能在胃癌發(fā)生、發(fā)展過程中起重要作用。上述結(jié)論尚需更多大樣本、設(shè)計嚴(yán)謹(jǐn)?shù)母哔|(zhì)量研究加以驗(yàn)證。
[Abstract]:Objective to investigate the relationship between CD133 protein expression and gastric cancer and its clinicopathological features in order to understand the role of CD133 in the carcinogenesis and development of gastric cancer. In order to provide evidence-based medicine basis for the treatment and prognosis intervention of gastric cancer. Methods Chinese biomedical literature database, Chinese scientific and technological journal full-text database, Chinese journal full-text database, Wanfang database were searched by computer from the construction of the database to October 2013, and the database was retrieved by hand. A case-control study on the correlation between CD133 protein expression and gastric cancer and its clinicopathological features was studied. After the two researchers sifted the literature according to the pre-established exclusion criteria, extracted the data and evaluated the quality of methodology, the Meta-analysis was carried out with Revman 5.2 software. Stata 11.0 was used to test Begg and Egger, and Begg and Egger were drawn. Finally, gradepro 3.6 was used to classify the quality of evidence. The results were eventually included in 9 case-control studies, Meta-analysis of 623 patients showed that the proportion of CD133 protein was present in gastric cancer group, paracancerous group and normal gastric tissue group [OR3.899 995 CI (1.87 鹵8.11) P0. 0003], lymph node metastasis group and non lymph node metastasis group [OR2. 755 + 95 CI (1. 993. 81) P 0. 00001], gastric cancer stage 鈪,

本文編號:2106899

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/zlx/2106899.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶78124***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
免费亚洲黄色在线观看| 欧美一区二区三区性视频| 91欧美一区二区三区| 国产一区二区三中文字幕| 日韩精品视频免费观看| 亚洲美女国产精品久久| 五月婷婷六月丁香亚洲| 亚洲国产av一二三区| 亚洲综合激情另类专区老铁性| 亚洲中文字幕亲近伦片| a久久天堂国产毛片精品| 九九热精品视频免费观看| 欧美人妻一区二区三区| 欧美日韩亚洲巨色人妻| 亚洲av专区在线观看| 在线欧美精品二区三区| 婷婷激情四射在线观看视频| 久久精品国产一区久久久| 国产成人精品视频一区二区三区| 激情中文字幕在线观看| 国产成人午夜在线视频| 在线日本不卡一区二区| 亚洲中文字幕有码在线观看| 亚洲国产成人一区二区在线观看| 日本欧美一区二区三区在线播| 国产av一区二区三区四区五区| 欧美性猛交内射老熟妇| 亚洲欧美日韩网友自拍| 欧美中文日韩一区久久| 亚洲精品国产主播一区| 人人妻在人人看人人澡| 国产精品欧美一区两区| 色婷婷激情五月天丁香| 国产又粗又猛又爽色噜噜| 精品国产一区二区欧美| 日韩一区二区三区高清在| 欧美成人高清在线播放| 在线欧洲免费无线码二区免费| 91一区国产中文字幕| av在线免费播放一区二区| 久热99中文字幕视频在线|