本文選題：宮頸細(xì)胞學(xué) + 高危型HPV檢測��； 參考：《中國婦產(chǎn)科臨床雜志》2017年01期

【摘要】：目的 對宮頸細(xì)胞學(xué)、高危型HPV和聯(lián)合檢測(細(xì)胞學(xué)聯(lián)合高危型HPV檢測)3種方法在檢出宮頸癌及癌前病變中的作用進(jìn)行了比較。方法 從2014年1月至2015年12月在北京大學(xué)第三醫(yī)院婦科門診自愿行機(jī)會性篩查的婦女,進(jìn)行宮頸細(xì)胞學(xué)檢查和高危型HPV檢測及陰道鏡檢查和宮頸活檢組織病理學(xué)檢查。宮頸細(xì)胞學(xué)采用Surepath和Thinprep液基薄片的方法,高危型HPV檢測采用HC2和Cobas 4800檢測系統(tǒng)。結(jié)果兩年間共有3 467例婦女入組進(jìn)行機(jī)會性篩查,年齡24~65歲,宮頸細(xì)胞學(xué)檢出宮頸癌及癌前病變的漏診率(9.03%)高于高危型HPV檢測(2.66%)和聯(lián)合檢測(0.21%),差異有統(tǒng)計學(xué)意義(P0.001)。高危型HPV陽性的ASC-US、ASC-H、LSIL、HSIL和AGC經(jīng)組織病理學(xué)檢出≥CIN2病變的概率均比HPV陰性者高(P0.05)。結(jié)論 聯(lián)合檢測檢出宮頸癌及癌前病變的漏診率低于細(xì)胞學(xué)和HPV檢測,聯(lián)合檢測能為異常篩查結(jié)果的管理提供更多指導(dǎo)臨床的信息,并有助于提高宮頸腺癌的檢出。
[Abstract]:Objective to compare the role of cervical cytology, high risk HPV and combined detection (cytology combined with high risk HPV detection) in the detection of cervical cancer and precancerous lesions. Methods from January 2014 to December 2015, women who volunteered for opportunistic screening in gynecological outpatient clinic of Peking University third Hospital were examined with cervical cytology, high-risk HPV, colposcopy and cervical biopsy histopathology. Cervical cytology was performed by Surepath and Thinprep liquid-based smears, and HC2 and Cobas 4800 were used for high-risk HPV detection. Results A total of 3 467 women were selected for opportunistic screening, aged 24 to 65 years. The missed diagnosis rate of cervical cancer and precancerous lesions detected by cervical cytology (9.03%) was higher than that of high-risk HPV (2.66%) and combined detection (0.21%). The difference was statistically significant (P0.001). The probability of HSIL and AGC detecting 鈮，

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