本文選題：慢性應(yīng)激 + 腫瘤標(biāo)志物�。� 參考：《廣東醫(yī)學(xué)》2017年23期

【摘要】：目的探討慢性應(yīng)激損傷對(duì)模型大鼠消化系統(tǒng)相關(guān)血清腫瘤標(biāo)志物的影響。方法 Wistar大鼠20只,隨機(jī)分為模型組和空白組�？瞻捉M常規(guī)飼養(yǎng),模型組在常規(guī)飼養(yǎng)基礎(chǔ)上另外給予對(duì)應(yīng)的慢性應(yīng)激刺激[足底電擊(40 V,0.1 Hz),冰水游泳(4℃,5 min),禁水(24 h),禁食(24 h),束縛(4 h)],21 d后采血清,ELISA法測(cè)定血清CEA、CA199、CA724、AFP,比較兩組血清腫瘤標(biāo)志物變化并分析消化系統(tǒng)相關(guān)腫瘤標(biāo)志物變化與慢性應(yīng)激的相關(guān)性。結(jié)果模型組CEA、CA199、CA724、AFP高于空白組,差異有統(tǒng)計(jì)學(xué)意義(P0.01)。CA199、CA724、AFP與慢性應(yīng)激有相關(guān)性,且以AFP相關(guān)性最高,回歸分析得到的最佳回歸方程為Y=0.199+0.029CA724+0.001CA199+0.045AFP,復(fù)相關(guān)系數(shù)R=0.994,決定系數(shù)R2=0.998。結(jié)論慢性應(yīng)激損傷能刺激大鼠血清消化系統(tǒng)相關(guān)腫瘤標(biāo)志物升高,有直接誘發(fā)腫瘤發(fā)生的可能性。
[Abstract]:Objective to investigate the effect of chronic stress injury on serum tumor markers in digestive system of model rats. Methods Twenty Wistar rats were randomly divided into model group and blank group. Normal feeding in blank group, The model group was given the corresponding chronic stress stimulation on the basis of routine feeding [plantar electric shock 40 V / L 0.1 HzN, ice water swimming 4 鈩，

本文編號(hào)：1969365