本文選題：甲狀腺腫瘤 + 癌��； 參考：《中國(guó)普通外科雜志》2017年05期

【摘要】：目的:探討腫瘤微環(huán)境相關(guān)因子IL-6、IL-10、CXCR7在甲狀腺乳頭狀癌中的表達(dá)及臨床意義。方法:采用免疫組織化學(xué)方法檢測(cè)50例甲狀腺乳頭狀癌、20例結(jié)節(jié)性甲狀腺腫組織中IL-6、IL-10、CXCR7的表達(dá),比較三者在兩種組織中的表達(dá)差異,并分析三者與甲狀腺乳頭狀癌臨床病理因素的關(guān)系。結(jié)果:IL-6、IL-10、CXCR7蛋白在甲狀腺乳頭狀癌中的陽(yáng)性表達(dá)率均明顯高于結(jié)節(jié)性甲狀腺腫組(62.0%vs.30.0%,52.0%vs.20.0%,66.0%vs.35.0%,均P0.05)。甲狀腺乳頭狀癌中IL-6、IL-10的高表達(dá)與癌灶的包膜侵犯有關(guān)(均P0.05),CXCR7的高表達(dá)與淋巴結(jié)轉(zhuǎn)移有關(guān)(P0.05)。結(jié)論:腫瘤微環(huán)境相關(guān)因子IL-6、IL-10和CXCR7在甲狀腺乳頭狀癌組織中表達(dá)上調(diào),其表達(dá)水平可作為評(píng)估甲狀腺乳頭狀癌惡性侵襲及轉(zhuǎn)移參考的指標(biāo)。
[Abstract]:Objective: to investigate the expression and clinical significance of tumor microenvironment related factor IL-6, IL-10 and CXCR7 in papillary thyroid carcinoma. Methods: immunohistochemical method was used to detect the expression of IL-6, IL-10 and CXCR7 in 50 cases of papillary thyroid carcinoma and 20 cases of nodular goiter. The relationship between the three factors and the clinicopathological factors of papillary thyroid carcinoma was analyzed. Results the positive expression rate of CXCR7 protein in papillary thyroid carcinoma was significantly higher than that in nodular goiter group (P 0.05). The high expression of IL-6 and IL-10 in papillary thyroid carcinoma was associated with the invasion of the capsule (P 0.05) and the high expression of CXCR7 was associated with lymph node metastasis (P 0.05). Conclusion: tumor microenvironment related factors IL-6, IL-10 and CXCR7 are up-regulated in papillary thyroid carcinoma. The expression level of IL-10 and CXCR7 may be used as a reference index to evaluate the malignant invasion and metastasis of papillary thyroid carcinoma.
【作者單位】： 江蘇大學(xué)附屬醫(yī)院甲乳外科;江蘇大學(xué)附屬醫(yī)院耳鼻喉科;江蘇大學(xué)附屬醫(yī)院病理科;
【基金】：江蘇省鎮(zhèn)江市重點(diǎn)研發(fā)計(jì)劃-社會(huì)發(fā)展課題基金資助，

本文編號(hào)：1961345