本文選題：胃腫瘤 + Lauren分型��； 參考：《中國全科醫(yī)學(xué)》2017年13期

【摘要】：目的探討腸型胃癌和彌漫型胃癌的臨床特點及預(yù)后。方法選取2007-01-01至2015-12-30在長治醫(yī)學(xué)院附屬和平醫(yī)院外科病房手術(shù)治療的胃癌患者392例,其中腸型231例(58.9%),彌漫型161例(41.1%)。建立胃癌流行病學(xué)調(diào)查問卷,并由經(jīng)過培訓(xùn)的專業(yè)人員按統(tǒng)一標(biāo)準(zhǔn)采集胃癌患者信息,包括基本情況(性別、年齡、身高、體質(zhì)量、文化程度、婚姻狀況、血型、幽門螺桿菌感染、腫瘤家族史)、生活方式及習(xí)慣(吸煙、飲酒、進(jìn)食速度、進(jìn)食燙食、進(jìn)食酸菜/咸菜/泡菜、進(jìn)食油炸食品)及病理診斷與臨床分期等;并由本院中心實驗室具有碩士及以上學(xué)歷人員對患者進(jìn)行電話隨訪,詢問生存情況,隨訪截至2015-12-30。結(jié)果腸型與彌漫型胃癌患者性別、體質(zhì)指數(shù)(BMI)、文化程度、婚姻狀況、血型、幽門螺桿菌感染、腫瘤家族史比較,差異無統(tǒng)計學(xué)意義(P0.05);腸型與彌漫型胃癌患者年齡比較,差異有統(tǒng)計學(xué)意義(P0.05)。腸型與彌漫型胃癌患者吸煙、飲酒比較,差異有統(tǒng)計學(xué)意義(P0.05);腸型與彌漫型胃癌患者進(jìn)食速度、進(jìn)食燙食、進(jìn)食酸菜/咸菜/泡菜、進(jìn)食油炸食品比較,差異無統(tǒng)計學(xué)意義(P0.05)。腸型與彌漫型胃癌患者T期、M期比較,差異無統(tǒng)計學(xué)意義(P0.05);腸型與彌漫型胃癌患者N期比較,差異有統(tǒng)計學(xué)意義(P0.05)。340例胃癌患者完成隨訪,隨訪率為86.7%;截至隨訪日期,腸型胃癌患者生存率為66.5%(129/194),中位生存時間為24個月;彌漫型胃癌患者生存率為52.7%(77/146),中位生存時間為18個月。腸型與彌漫型胃癌患者生存曲線比較,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論不同Lauren分型胃癌臨床特點和預(yù)后不同。Lauren分型在胃癌治療及預(yù)防中起一定的決策作用。
[Abstract]:Objective to investigate the clinical features and prognosis of intestinal and diffuse gastric cancer. Methods 392 patients with gastric cancer were selected from January 1, 2007 to May 12, 2015-30 in the surgical ward of the affiliated Peace Hospital of Changzhi Medical College. 231 cases of intestinal type and 161 cases of diffuse type were selected. A questionnaire on gastric cancer epidemiology was established and trained professionals were trained to collect information on gastric cancer patients according to uniform criteria, including basic information (sex, age, height, body mass, education, marital status, blood type). Helicobacter pylori infection, family history of cancer, lifestyle and habits (smoking, drinking, eating speed, eating hot food, eating pickles / pickles, eating fried food), pathological diagnosis and clinical stages. And from the central laboratory of our hospital with master's degree and above to carry on the telephone follow-up to the patient, inquire the survival condition, follow up to 2015-12-30. Results there was no significant difference in sex, BMI, education, marital status, blood group, Helicobacter pylori infection, family history of tumor between intestinal type and diffuse type of gastric cancer (P 0.05). The difference was statistically significant (P 0.05). There was significant difference in smoking and drinking between intestinal type and diffuse type of gastric cancer (P 0.05), but there was no significant difference between intestinal type and diffuse type of gastric cancer in terms of eating speed, hot food, pickle / pickle and fried food (P 0.05). There was no significant difference in T phase M stage between intestinal type and diffuse type of gastric cancer, but there was no significant difference between intestinal type and diffuse type of gastric cancer in N stage, and there was significant difference in P 0.05% and 340 cases of gastric cancer with a follow-up rate of 86.7%. The survival rate of patients with intestinal type gastric cancer was 12.9 / 194, the median survival time was 24 months, and the survival rate of diffuse gastric cancer patients was 52.777 / 146, with a median survival time of 18 months. There was significant difference in survival curve between intestinal type and diffuse type of gastric cancer (P 0.05). Conclusion the clinical characteristics and prognosis of gastric cancer with different Lauren types are different. Lauren's classification plays a decisive role in the treatment and prevention of gastric cancer.
【作者單位】： 長治醫(yī)學(xué)院預(yù)防醫(yī)學(xué)系流行病與衛(wèi)生統(tǒng)計學(xué)教研室;長治醫(yī)學(xué)院附屬和平醫(yī)院中心實驗室;
【基金】：山西省基礎(chǔ)研究計劃項目(2015021185) 國家自然科學(xué)基金資助項目(81302518) 山西省長治醫(yī)學(xué)院創(chuàng)新團(tuán)隊(CX201403)
【分類號】：R735.2

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