本文選題：保婦康栓 + 殼聚糖抗菌膜��； 參考：《中國藥房》2017年03期

【摘要】：目的:探討保婦康栓聯(lián)合殼聚糖抗菌膜對宮頸上皮內(nèi)瘤變(CIN)患者行宮頸錐切術(shù)后療效及相關(guān)指標(biāo)的影響。方法:200例擬行宮頸錐切術(shù)的CIN患者隨機(jī)分為對照組(100例)和觀察組(100例)。兩組患者均于月經(jīng)干凈2~7 d后行宮頸錐切術(shù);術(shù)后,對照組患者給予殼聚糖抗菌膜1片,以無菌操作桿推入陰道并貼敷于創(chuàng)面,以紗塊進(jìn)行填塞,每2 d更換1次;觀察組患者在對照組治療的基礎(chǔ)上給予保婦康栓1粒,陰道置入,每日1次。兩組療程均為2周。觀察兩組患者的臨床療效,創(chuàng)面愈合時間、陰道排液時間,治療前后的炎癥因子[白細(xì)胞介素(IL)-4、IL-10、腫瘤壞死因子(TNF)-α]水平,記錄術(shù)后并發(fā)癥及不良反應(yīng)發(fā)生情況。結(jié)果:觀察組患者總有效率顯著高于對照組,創(chuàng)面愈合時間和陰道排液時間均顯著短于對照組,術(shù)后并發(fā)癥發(fā)生率顯著低于對照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者炎癥因子水平均顯著低于同組治療前,且觀察組顯著低于對照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:宮頸錐切術(shù)后,保婦康栓聯(lián)合殼聚糖抗菌膜治療CIN的療效顯著,可有效提高術(shù)后患者創(chuàng)面愈合效果,降低炎癥反應(yīng)水平及術(shù)后并發(fā)癥發(fā)生率,且不增加不良反應(yīng)的發(fā)生。
[Abstract]:Objective: to investigate the effect of Baofukang suppository combined with chitosan antibacterial membrane on the postoperative efficacy and related indexes of cervical intraepithelial neoplasia (CINs) patients. Methods two hundred patients with CIN were randomly divided into control group (n = 100) and observation group (n = 100). The patients in both groups were treated with cervical conization 7 days after menorrhagia, the patients in control group were treated with chitosan antibacterial film 1 tablet, and then applied to the wound with aseptic pole, then filled with yarn and replaced once every 2 days. The patients in the observation group were given 1 capsule of Baofukang suppository on the basis of treatment in the control group, and the vagina was implanted once a day. The course of treatment was 2 weeks in both groups. The clinical efficacy, wound healing time, vaginal effusion time, the levels of inflammatory factor IL-10 and tumor necrosis factor TNF- 偽 before and after treatment were observed in the two groups. The postoperative complications and adverse reactions were recorded. Results: the total effective rate in the observation group was significantly higher than that in the control group, the wound healing time and vaginal drainage time were significantly shorter than those in the control group, and the incidence of postoperative complications was significantly lower than that in the control group (P 0.05). After treatment, the levels of inflammatory factors in both groups were significantly lower than those before treatment in the same group, and the levels of inflammatory factors in the observation group were significantly lower than those in the control group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: Baofukang suppository combined with chitosan antimicrobial membrane is effective in the treatment of CIN, which can effectively improve the wound healing effect, reduce the level of inflammatory reaction and the incidence of postoperative complications, and do not increase the incidence of adverse reactions.
【作者單位】： 漯河市中心醫(yī)院;漯河醫(yī)學(xué)高等�？茖W(xué)校藥學(xué)系;漯河市第三人民醫(yī)院藥劑科;
【分類號】：R737.33

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