本文選題：促甲狀腺激素 + 甲狀腺惡性腫瘤��； 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:研究血清促甲狀腺激素(thyroid stimulating hormone,TSH)水平與乳頭狀甲狀腺微癌(papillary thyroid microcarcinoma,PTMC)患者的臨床病理學(xué)特征間的關(guān)系。方法:總結(jié)分析從2012年1月至2015年4月在我科第一次接受手術(shù)的甲狀腺有病變的患者的臨床與病理學(xué)方面的資料,包括TSH水平、性別、年齡。其中符合入選標(biāo)準(zhǔn)的有806例,術(shù)后病理學(xué)檢查確診為乳頭狀甲狀腺微癌的病例數(shù)為403例,良性甲狀腺結(jié)節(jié)腫瘤病變者(BTN,benign thyroid nodules)為403例,予以回顧性分析所入選病例的病史及臨床病理學(xué)資料,并比較2組患者術(shù)前TSH水平、抗甲狀腺球蛋白抗體(thyroid globulin antibody,TGAb)水平以及比較2組患者一般資料(包括:性別、年齡、族別、病灶大小等),最終比較不同TSH水平之間PTMC患者所占比例,對乳頭狀甲狀腺微癌的危險因素進(jìn)行單因素和多因素的logistic回歸分析。結(jié)果:甲狀腺良性組中男173例,女633例,男:女比例為1:4.30。乳頭狀甲狀腺微癌組中男76例,女327例,男:女比例為1:4.30;良性組男97例,女306例,男:女為1:3.15。2組之間男女構(gòu)成比例的差異無統(tǒng)計學(xué)意義(χ~2=3.246,P=0.072)。2組間年齡差異有統(tǒng)計學(xué)意義(Z=-5.855,P=0.001)。乳頭狀甲狀腺微癌和良性甲狀腺結(jié)節(jié)腫瘤2組病例術(shù)前TSH水平的差異有統(tǒng)計學(xué)意義(Z=-6.233,P=0.001);2組間民族構(gòu)成的差異有統(tǒng)計學(xué)意義(χ2=38.961,P=0.001)。logistic回歸分析顯示:年齡和TSH水平是乳頭狀甲狀腺微癌的獨(dú)立危險因素(年齡:OR=0.914,P=0.027;TSH:OR=4.662,P=0.008)。結(jié)論:乳頭狀甲狀腺微癌患者血清TSH水平較甲狀腺良性結(jié)節(jié)患者高,血清TSH水平的高低可能與乳頭狀甲狀腺微癌的發(fā)生有關(guān),血清TSH是預(yù)測乳頭狀甲狀腺微癌風(fēng)險的指標(biāo)之一。
[Abstract]:Objective: to study the relationship between serum thyroid stimulating hormone (TSH) levels and clinicopathological features of papillary thyroid carcinomas (PTMCs). Methods: from January 2012 to April 2015, the clinical and pathological data, including TSH level, sex and age, of the patients with thyroid lesions underwent the first operation in our department were summarized and analyzed. Among them, 806 cases met the inclusion criteria, 403 cases were diagnosed as papillary thyroid microcarcinoma by postoperative pathological examination, 403 cases were diagnosed as benign thyroid nodules, and 403 cases were diagnosed as benign thyroid nodules. The history and clinicopathological data of the selected patients were retrospectively analyzed, and the preoperative TSH levels, the levels of thyroid globulin antibody-tGAbs and the general data of the two groups (including sex, age, race) were compared. The proportion of PTMC patients with different TSH levels was compared and the risk factors of papillary thyroid microcarcinoma were analyzed by univariate and multivariate logistic regression analysis. Results: there were 173 males and 633 females in benign thyroid group. The ratio of male to female was 1: 4.30. In the papillary thyroid microcarcinoma group, there were 76 males and 327 females, the ratio of male to female was 1: 4.30; in benign group, there were 97 males, 306 females and 1: 3.15.2 males: females. There were significant differences in preoperative TSH levels between the two groups of patients with papillary thyroid microcarcinoma and benign thyroid nodule tumor. There was a significant difference in ethnic composition between the two groups (蠂 ~ 2 / 38.961p ~ (0.001). Logistic regression analysis showed that age and TSH level were papillary. The independent risk factors of thyroid microcarcinoma (age: 0. 914) and TSH: 4.662 (P = 0. 008). Conclusion: the level of serum TSH in patients with papillary thyroid microcarcinoma is higher than that in patients with benign thyroid nodules. The level of serum TSH may be related to the occurrence of papillary thyroid microcarcinoma. Serum TSH is one of the predictors of the risk of papillary thyroid microcarcinoma.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R736.1

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