本文選題：幽門螺桿菌 + 胰腺癌　； 參考：《暨南大學》2015年碩士論文

【摘要】：目的:探討幽門螺桿菌(Helicobacter pylori,H.pylori)感染與胰腺癌的關系。方法:檢索相關文獻,對符合納入標準的文獻進行資料提取,用Revman5.3軟件進行meta分析,估計合并效應量OR值及對應的95%可信區(qū)間(95%CI),再繪制漏斗圖評價發(fā)表性偏倚。結果:共納入8篇文獻,病例組和對照組共3133例。H.pylori感染與胰腺癌關系的合并OR值為1.27,95%CI:1.04-1.56,I2=24%。按照研究對象人種不同,分為東、西方兩個亞組,西方人群(OR=1.14,95%CI:0.91-1.42,I2=0%),表明H.pylori感染與胰腺癌沒有關系,但東方人群(OR=2.06,95%CI:1.29-3.29,I2=0%),表明H.pylori感染與胰腺癌有關系,且H.pylori感染是胰腺癌的危險因素,倒漏斗圖示基本對稱。有6篇文獻檢測Cag A+,其合并OR值為1.32,95%CI:0.83-2.10,I2=72%,亞組分析示西方人群(OR=0.92,95%CI:0.73-1.16,I2=0%),表明Cag A+與胰腺癌沒有關系,但東方人群(OR=4.29,95%CI:2.14-8.60,I2=0%),表明Cag A+與胰腺癌有關系,且Cag A+可增加患胰腺癌的風險。結論:東方人群H.pylori感染和Cag A+可增加患胰腺癌的風險,西方人群H.pylori感染和Cag A+與胰腺癌沒有關系。
[Abstract]:Objective: to investigate the relationship between Helicobacter pylori H.pylori infection and pancreatic cancer. Methods: the relevant literature was retrieved, and the data of the literature that met the inclusion criteria were extracted. The meta analysis was carried out with Revman5.3 software. The OR value of the combined effect and the 95% confidence interval (95% CI) were estimated, and then the funnel graph was drawn to evaluate the published bias. Results: a total of 8 articles were included. The OR value of 3133 cases of H.pylori infection and pancreatic cancer was 1.2795 CI: 1.04-1.56I224.4. According to the different race of the subjects, they were divided into two subgroups of east and west, and the Western population was 1.1495, and the H.pylori infection had no relationship with pancreatic cancer, but the oriental population had no relationship with pancreatic cancer, which indicated that H.pylori infection was associated with pancreatic cancer, and H.pylori infection was the risk factor of pancreatic cancer. The inverted funnel is basically symmetrical. Six papers examined Cag A, with a OR value of 1.32 鹵95CI0.83-2.10 and I2720.The subgroup analysis showed that Cag A had no relationship with pancreatic cancer, but Cag A had no relationship with pancreatic cancer, indicating that Cag A was associated with pancreatic cancer, and Cag A could increase the risk of pancreatic cancer. Conclusion: H.pylori infection and Cag A in oriental population can increase the risk of pancreatic cancer, but H.pylori infection and Cag A in western population are not associated with pancreatic cancer.
【學位授予單位】：暨南大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R735.9

【參考文獻】

相關期刊論文 前2條

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2 Hans-Olof Nilsson;Unne Stenram;Ingemar Ihse;Torkel Wadstr(o|¨)m;;Helicobacter species ribosomal DNA in the pancreas, stomach and duodenum of pancreatic cancer patients[J];World Journal of Gastroenterology;2006年19期

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本文編號：1803665