本文選題：預(yù)后營養(yǎng)指數(shù) + 血紅蛋白�。� 參考：《山東大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年04期

【摘要】：目的探討預(yù)后營養(yǎng)指數(shù)(PNI)及血紅蛋白(HGB)評(píng)估中晚期非小細(xì)胞肺癌患者預(yù)后的臨床價(jià)值。方法選取2013年8月至2015年8月首次確診的、符合本研究條件的中晚期非小細(xì)胞肺癌患者的臨床資料;通過電子病歷系統(tǒng)、門診及電話等方法對(duì)所有患者進(jìn)行隨訪,隨訪截止到患者死亡或2016年8月;根據(jù)PNI中位數(shù)(46.52)及HGB中位數(shù)(115 g/L)將患者分為高PNI組、低PNI組及高HGB組、低HGB組;通過單因素及多因素分析PNI及HGB對(duì)患者總生存期(OS)的影響;制作兩組患者的Kaplan-Meier生存曲線,同時(shí)行Log-rank檢驗(yàn)。通過單因素分析PNI及HGB相關(guān)影響因素。結(jié)果單因素變量分析示首次確診時(shí)年齡≥65歲、吸煙指數(shù)≥400、PNI46.52、HGB115 g/L的患者OS明顯低于年齡65歲、吸煙指數(shù)400、PNI≥46.52、HGB≥115 g/L的患者OS(P0.05);PNI與患者年齡、臨床分期、胸腔積液及吸煙指數(shù)密切相關(guān)(P0.05);HGB與患者年齡、體質(zhì)量下降率密切相關(guān)(P0.05)。多因素分析示僅PNI及HGB對(duì)患者OS的影響有統(tǒng)計(jì)學(xué)意義[Exp(B)=2.180,P0.001;Exp(B)=2.032,P=0.001]。繪制Kaplan-Meier生存曲線同時(shí)行Log-rank檢驗(yàn)示,高PNI組與低PNI組患者、高HGB組與低HGB組患者OS差異有統(tǒng)計(jì)學(xué)意義(P0.001)。結(jié)論P(yáng)NI及HGB可作為中晚期非小細(xì)胞肺癌患者預(yù)后的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to evaluate the prognostic value of prognostic nutrition index (PNI) and hemoglobin (HGB) in patients with advanced non small cell lung cancer (NSCLC).Methods the clinical data of patients with advanced non-small cell lung cancer (NSCLC), who were first diagnosed from August 2013 to August 2015, were followed up by electronic medical record system, outpatient service and telephone, etc.According to the median of PNI (46.52) and HGB (115g / L), the patients were divided into three groups: high PNI group, low PNI group and high HGB group, low HGB group, univariate and multivariate analysis of the influence of PNI and HGB on total survival time.The Kaplan-Meier survival curves of the two groups were made and the Log-rank test was performed at the same time.The related factors of PNI and HGB were analyzed by univariate analysis.Results the univariate analysis showed that the patients with smoking index 鈮，

本文編號(hào)：1769726