本文選題：二氫嘧啶脫氫酶 + 亞甲基四氫葉酸還原酶�。� 參考：《中國(guó)臨床藥理學(xué)雜志》2017年17期

【摘要】：目的分析結(jié)直腸癌患者二氫嘧啶脫氫酶(DPYD)和亞甲基四氫葉酸還原酶(MTHFR)基因多態(tài)性的分布情況及基因多態(tài)性與卡培他濱方案治療的藥物不良反應(yīng)的相關(guān)性。方法回顧性分析我院2015年4月至2016年10月治療的81例結(jié)直腸癌患者DPYD、MTHFR基因型的分布情況,用數(shù)字熒光分子雜交(DFMH)技術(shù)對(duì)患者基因型進(jìn)行測(cè)定。藥物不良反應(yīng)評(píng)價(jià)按照美國(guó)國(guó)立癌癥研究所常規(guī)藥物不良反應(yīng)判定標(biāo)準(zhǔn)3.0(NCI-CTCAE3.0)實(shí)施。結(jié)果 81例結(jié)直腸癌患者DPYD基因檢測(cè)未發(fā)現(xiàn)突變型,而MTHFR基因檢測(cè)結(jié)果分布如下:MTHFR(1298AC)野生型A/A、雜合突變型A/C和純合突變型C/C分別為57例(70.37%),21例(25.93%)和3例(3.70%)。MTHFR基因純合突變型(C/C型)和雜合突變型(A/C型)發(fā)生Ⅱ~Ⅳ度惡心嘔吐風(fēng)險(xiǎn)高于野生型(A/A),分別為33.33%,19.05%和1.75%(P0.05)。MTHFR突變型基因發(fā)生Ⅱ~Ⅳ度白細(xì)胞減少和血小板減少的風(fēng)險(xiǎn)高于野生型,但差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論在我院尚未發(fā)現(xiàn)DPYD基因突變型患者,MTHFR基因多態(tài)性可以預(yù)測(cè)卡培他濱方案治療結(jié)直腸癌患者發(fā)生藥物不良反應(yīng)的風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the distribution of dihydropyrimidine dehydrogenase (DPYD) and methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in patients with colorectal cancer and the relationship between polymorphism and adverse drug reactions (ADR) after capecitabine therapy.Methods the distribution of DPYD- MTHFR genotypes in 81 patients with colorectal cancer treated in our hospital from April 2015 to October 2016 was analyzed retrospectively. The genotypes were determined by digital fluorescent molecular hybridization (DFMH) technique.Adverse drug reaction (ADR) evaluation was performed according to the National Cancer Institute (NCI-CTCAE 3.0) criteria for the determination of adverse drug reactions (NCI-CTCAE 3.0).Results there was no mutation in DPYD gene in 81 patients with colorectal cancer.The results of MTHFR gene detection were as follows: the wild type A / A, the heterozygous mutant A / C and the homozygous mutant C / C were 57 cases (70.37) and 21 cases (25.93%), respectively) and 3 cases (C / C) of homozygous type C (C / C) and heterozygous mutant type (Ac).The risk of vomiting was higher than that of wild type A / A, which was 33.33% and 19.05%, respectively, and the risk of grade 鈪，

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