本文選題：NANOG + CTLA-4　； 參考：《昆明理工大學(xué)》2015年碩士論文

【摘要】：本論文是通過(guò)收集已有的關(guān)于NANOG同CTLA-4蛋白在臨床試驗(yàn)的研究數(shù)據(jù),并用加權(quán)Youden指數(shù)合并效應(yīng)量的方法來(lái)改進(jìn)統(tǒng)計(jì)軟件使用的模型,最終通過(guò)改進(jìn)的方法模型去獲得NANOG同CTLA-4與胃癌腫瘤細(xì)胞之間的關(guān)系以及分析出藥物Ipilimumab在治療黑色素瘤過(guò)程中相對(duì)于傳統(tǒng)的手術(shù)化療法的效果強(qiáng)弱性。在對(duì)于方法改進(jìn)中首先假設(shè)各研究間相互獨(dú)立,同一個(gè)研究中的特異度和靈敏度也相互獨(dú)立并且服從二項(xiàng)分布。在固定效應(yīng)模型下建立加權(quán)Youden指數(shù)合并效應(yīng)量估計(jì)方法并采用最大似然估計(jì)法和最小二乘法進(jìn)行估計(jì)并進(jìn)行比較。在隨機(jī)效應(yīng)模型下構(gòu)建加權(quán)Youden指數(shù)的合并效應(yīng)量的估計(jì)方法并采用加權(quán)最小二乘方法進(jìn)行估計(jì)。最終采用Monte Carlo模擬比較各種方法的統(tǒng)計(jì)學(xué)性能。數(shù)據(jù)的獲取和分析是通過(guò)在PubMed、Mediun、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(CBM)、知網(wǎng)、維普、萬(wàn)方數(shù)據(jù)庫(kù)采用相同的檢索策略(關(guān)鍵詞：Nanog、CTLA-4、癌癥、隨機(jī)、對(duì)照)收集所有Nanog和CTLA-4相關(guān)的診斷性試驗(yàn),對(duì)最新的期刊進(jìn)行手工檢索；結(jié)合兩種檢索結(jié)果進(jìn)行資料的提取并應(yīng)用QUADAS質(zhì)量評(píng)價(jià)標(biāo)準(zhǔn)進(jìn)行質(zhì)量評(píng)估后,采用RevMan分析軟件用改進(jìn)的方法進(jìn)行系統(tǒng)性分析,得出我們想要的結(jié)論。最終的結(jié)果表明,在加權(quán)Youden指數(shù)合并效應(yīng)量的方法改進(jìn)下,統(tǒng)計(jì)性能有所提高。通過(guò)新模型對(duì)于數(shù)據(jù)的統(tǒng)計(jì)分析,得出NANOG同胃癌細(xì)胞、不同的胃癌分期以及胃癌細(xì)胞的轉(zhuǎn)移有著強(qiáng)關(guān)聯(lián)性,并且分析了CTLA-4四組等位基因同胃癌是否有關(guān),最后分析出Ipilimumab相對(duì)傳統(tǒng)的手術(shù)化療法對(duì)于黑色素瘤的治療有著更加明顯的療效。
[Abstract]:This paper is to improve the model of statistical software by collecting the existing research data about NANOG and CTLA-4 protein in clinical trials and using weighted Youden index to combine effect quantity.Finally, the relationship between NANOG and CTLA-4 and gastric cancer tumor cells was obtained by the improved method model, and the effect of drug Ipilimumab in the treatment of melanoma was compared with that of traditional surgical therapy.In the improvement of the method, it is assumed that each study is independent of each other, the specificity and sensitivity of the same study are independent and the binomial distribution is obtained.Under the fixed effect model, the weighted Youden exponent combined effect quantity estimation method is established, and the maximum likelihood estimation method and the least square method are used to estimate and compare.Under the stochastic effect model, the method of estimating the combined effect quantity of weighted Youden exponent is constructed and the weighted least square method is used to estimate it.Finally, Monte Carlo is used to simulate and compare the statistical performance of various methods.The data were obtained and analyzed by collecting all diagnostic trials related to Nanog and CTLA-4 using the same retrieval strategy (keyword: Nanog CTLA-4, cancer, randomized, control) at PubMeden Mediun, the Chinese Biomedical Literature Database (CBM), Zhiwang, Wiper, and Wanfang.This paper carries on the manual retrieval to the newest periodical, combines two kinds of retrieval results to carry on the data extraction and the application QUADAS quality evaluation standard to carry on the quality appraisal, uses the RevMan analysis software to carry on the systematic analysis with the improved method, obtains the conclusion which we want.The final results show that the statistical performance is improved with the improvement of weighted Youden exponent combination effect quantity.Through the statistical analysis of the new model, it is concluded that there is a strong correlation between NANOG and gastric cancer cells, different stages of gastric cancer and metastasis of gastric cancer cells, and whether the four groups of CTLA-4 alleles are related to gastric cancer.Finally, it is concluded that Ipilimumab is more effective than conventional surgical therapy in the treatment of melanoma.
【學(xué)位授予單位】：昆明理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R730.5;O213

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本文編號(hào)：1764508