本文選題：多發(fā)性?xún)?nèi)分泌腺瘤病1型 + 臨床分析��； 參考：《浙江大學(xué)》2015年碩士論文

【摘要】：目的： 探討多發(fā)性?xún)?nèi)分泌腺瘤病1型(MEN-1)的臨床特點(diǎn)和治療,提高對(duì)其認(rèn)識(shí)水平。 方法： 回顧性分析2013年4月至2014年10月在浙江大學(xué)醫(yī)學(xué)院附屬邵逸夫醫(yī)院就診的4例MEN-1患者的臨床資料。 結(jié)果： 4例患者皆有甲狀旁腺腺瘤,3例明確合并胰腺神經(jīng)內(nèi)分泌腫瘤,1例高度懷疑合并胰腺神經(jīng)內(nèi)分泌腫瘤,1例合并垂體瘤,臨床表現(xiàn)因涉及的腺體不同而異。4例患者最后都進(jìn)行了手術(shù)治療,切除了腫瘤。 文獻(xiàn)學(xué)習(xí)： 多發(fā)性?xún)?nèi)分泌腺瘤病1型是一種常染色體顯性遺傳病,可以出現(xiàn)內(nèi)分泌各個(gè)靶器官的腫瘤。其致病基因位于染色體11q13,稱(chēng)為menin基因。MEN-1迄今為止所知道的內(nèi)分泌腫瘤有20多種,其臨床表現(xiàn)各種各樣。MEN-1治療與非MEN-1單發(fā)的內(nèi)分泌腺瘤治療方式相似,以手術(shù)為主,輔以?xún)?nèi)科治療、化療、分子靶向藥物等。 結(jié)論： 應(yīng)重視MEN-1型的診斷線(xiàn)索,早期診斷和早期治療。MEN-1型的診斷和治療需要多學(xué)科的合作。
[Abstract]:Objective:To investigate the clinical features and treatment of multiple endocrine adenomatosis type 1 (MEN 1) and to improve its understanding.Methods:The clinical data of 4 patients with MEN-1 from April 2013 to October 2014 in run run Shaw Hospital affiliated to Zhejiang University Medical College were retrospectively analyzed.Results:All the 4 patients had parathyroid adenoma. 3 cases were confirmed to have pancreatic neuroendocrine tumor. 1 case was highly suspected to have pancreatic neuroendocrine tumor and 1 case was associated with pituitary adenoma.The clinical manifestations varied according to the glands involved. 4. 4 cases were treated surgically and the tumor was removed.Literature learning:Multiple endocrine adenomatosis type 1 is an autosomal dominant hereditary disease.The pathogenetic gene is located on chromosome 11q13, which is called menin gene. MEN-1 is known to be more than 20 kinds of endocrine tumors so far. Its clinical manifestations are similar to those of non-#en1# single endocrine adenoma.With medical treatment, chemotherapy, molecular targeted drugs and so on.Conclusion:Attention should be paid to the diagnostic cues of MEN-1 type. The diagnosis and treatment of early diagnosis and treatment of MEN-1 require multidisciplinary cooperation.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：R736

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