本文關(guān)鍵詞：腫瘤新生血管及分子靶向治療新策略，由筆耕文化傳播整理發(fā)布。

靶向制劑,靶向制劑研究,靶向性藥物,靶向性藥物評價

Progenitors

Primitivevascularnetwork

Capilary

Maturevascularnetwork

Vein

圖1血管發(fā)生和血管生成血管發(fā)生：內(nèi)皮前體細(xì)胞形成一個原始的血管網(wǎng)絡(luò)。血管生成：原始血

管網(wǎng)擴(kuò)張，形成動脈、靜脈和毛細(xì)血管周細(xì)胞和平滑肌細(xì)胞環(huán)繞形成完整的新生血管(圖引自[4]并得到許可)

Fig.1ThedevelopmentofthevascularsystemsDuringvasculogenesis,endothelialprogenitors

giverisetoaprimitivevascularlabyrinthofarteresandveins;duringsubsequentangiogenesis,thenetworkexpands,pericytes(PCs)andsmoothmusclecells(SMCs)covernascentendothelialchannels,andastereotypicallyorganizedvascularnetworkemerges(FiguretakenfromRef.4withpermissionfromthepublisher)

皮細(xì)胞從靜止?fàn)顟B(tài)變成具有遷移能力的頂細(xì)胞(tipcell)，同時激活間質(zhì)金屬蛋白酶(matrixmetalloproteinase，MMP2或MMP9)降解血管外基質(zhì)，幫助頂細(xì)胞向周圍擴(kuò)增和遷移形成柱狀絲狀偽足，并逐步形成血管腔(lumen)。最后，周細(xì)胞(pericytecell，PC)和血管平滑肌細(xì)胞(vascularsmoothmusclecell，SMC)等支持細(xì)胞(muralcell)環(huán)繞在內(nèi)皮細(xì)胞周圍形成完整的新生血管(圖2)。

圖2

Endothelialcell

(A)Pre-existingbloodvessel

Muralcell

血管生成(A)原有正常血管；(B)內(nèi)皮細(xì)

胞由靜止?fàn)顟B(tài)轉(zhuǎn)變成具有遷移能力的頂細(xì)胞；(C)頂細(xì)胞向周圍擴(kuò)增和遷移形成柱狀或絲狀偽足，，并逐步形成血管腔(lumen)，內(nèi)皮細(xì)胞出芽；(D)血管腔形成；(E)在細(xì)胞粘附作用和周細(xì)胞、血管平滑肌細(xì)胞等支持細(xì)胞的作用下形成成熟且穩(wěn)定的新生血管(圖引自[9]并得到許可)

Fig.2SchematicrepresentationoftheangiogenicprocessshowingAngiogenesisstartsfrompre-existingvessels(A),withtheconversionofapreviouslyquiescentendothelialcellintoatip(B).Thelatterformsfilopodiathatprobethesurroundingenvironmentwhichistheninvadedbytheendothelialsprout,wherethetipcellisfollowedbythemigratingcolumn,formedbyproliferatingendothelialcell(C).Duringendothelialsprouting,vacuolesformingwithinstalkcellscoalesceandgiverisetothevascularlumen(D).Uponformationofthenewvessel,thisundergoesstabilizationandmaturation,aprocessmainlymediatedbyintercellularadhesionandmuralcellcoverage(E)(FiguretakenfromRef.9withpermissionfromthepublisher)

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(B)Tipcellformation

Tipcell

Tipcell

(C)Endothelialsproutformation

Migratingcolumn

(D)Lumenformation

(E)Maturation

｜ACTABIOPHYSICASINICA

  本文關(guān)鍵詞：腫瘤新生血管及分子靶向治療新策略，由筆耕文化傳播整理發(fā)布。