發(fā)布時(shí)間：2018-04-09 03:21

  本文選題：宮頸癌　切入點(diǎn)：miR-　出處：《醫(yī)學(xué)研究生學(xué)報(bào)》2017年01期

【摘要】：微小RNA(miRNA)可在轉(zhuǎn)錄后水平調(diào)控腫瘤相關(guān)基因的表達(dá),從而在腫瘤發(fā)生發(fā)展等過(guò)程中發(fā)揮重要作用。研究顯示,miR-214在宮頸癌細(xì)胞中表達(dá)異常,并可通過(guò)與多種宮頸癌相關(guān)基因(包括Plexin-B1、GALNT7以及TFAM等)的相互作用抑制宮頸癌細(xì)胞的增殖、遷移、侵襲能力,促進(jìn)宮頸癌細(xì)胞的凋亡。文中就近年來(lái)有關(guān)miR-214在宮頸癌中的研究進(jìn)展進(jìn)行綜述,以期探索miR-214與宮頸癌發(fā)生發(fā)展之間的關(guān)系,并為宮頸癌的臨床診斷和治療提供新的思路。
[Abstract]:Small RNAs miRNAs can regulate the expression of tumor-related genes at post-transcriptional level and thus play an important role in tumorigenesis and development.The results showed that the expression of miR-214 was abnormal in cervical cancer cells, and could inhibit the proliferation, migration and invasion of cervical cancer cells and promote the apoptosis of cervical cancer cells through the interaction of many kinds of cervical cancer related genes (including Plexin-B1GALNT7 and TFAM).This paper reviews the research progress of miR-214 in cervical cancer in recent years in order to explore the relationship between miR-214 and the occurrence and development of cervical cancer and to provide new ideas for clinical diagnosis and treatment of cervical cancer.
【作者單位】： 中國(guó)醫(yī)學(xué)科學(xué)院&北京協(xié)和醫(yī)學(xué)院醫(yī)學(xué)生物學(xué)研究所;昆明醫(yī)科大學(xué)第三附屬醫(yī)院婦科;
【基金】：國(guó)家自然科學(xué)基金(31270030,81573206) 云南省科技廳-昆明醫(yī)科大學(xué)應(yīng)用基礎(chǔ)研究聯(lián)合專(zhuān)項(xiàng)(2013FB169) 云南省醫(yī)療衛(wèi)生單位內(nèi)設(shè)研究機(jī)構(gòu)科研項(xiàng)目(2014NS032)
【分類(lèi)號(hào)】：R737.33
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本文編號(hào)：1724624