發(fā)布時間：2018-04-02 15:12

  本文選題：口腔鱗癌　切入點(diǎn)：新輔助化療　出處：《口腔醫(yī)學(xué)研究》2017年12期

【摘要】：目的:觀察口腔鱗癌患者新輔助化療療效與5年生存率的關(guān)系,并探討P-gp、MRP1、GST-π與新輔助化療療效的關(guān)系。方法:1)收集南昌大學(xué)第一附屬醫(yī)院診治的口腔鱗癌石蠟標(biāo)本77例(有效組50例,無效組27例),隨訪5年生存時間,Envision法檢測P-gp、MRP1、GST-π表達(dá)水平;2)收集本單位口腔鱗癌新鮮標(biāo)本33例(有效組18例,無效組15例),qPCR、WesternBlot法檢測P-gp、MRP1、GST-π表達(dá)水平。結(jié)果:1)KaplanMeier顯示:有效組5年生存率高于無效組(P0.05)。2)Envision、qPCR、WesternBlot顯示:無效組化療后Pgp、MRP1表達(dá)上升量較有效組有顯著差異(P0.05),而GST-π表達(dá)上升量無顯著差異(P0.05)。結(jié)論:口腔鱗癌新輔助化療有效組5年生存率明顯高于無效組;化療療效與P-gp、MRP1表達(dá)相關(guān),表達(dá)上升量越高,療效越差。
[Abstract]:Objective: to investigate the relationship between the efficacy of neoadjuvant chemotherapy and 5 year survival rate in patients with oral squamous cell carcinoma (SCC), and to explore the relationship between P-gpMr MRP1GST- 蟺 and neoadjuvant chemotherapy.Methods A total of 77 cases of oral squamous cell carcinoma (OSCC) were collected from the first affiliated Hospital of Nanchang University (effective group, 50 cases).Twenty-seven cases of ineffective group were followed up for 5 years to detect the expression level of GST- 蟺 by envision method. 33 cases of oral squamous cell carcinoma were collected (18 cases of effective group and 15 cases of ineffective group) to detect the expression of GST- 蟺 in MRP1GST- 蟺 by Western Blot.Conclusion: the 5-year survival rate of neoadjuvant chemotherapy in oral squamous cell carcinoma is significantly higher than that in ineffective group, and the effect of chemotherapy is correlated with the expression of P-gpfen MRP1, and the higher the expression level is, the worse the curative effect is.
【作者單位】： 南昌大學(xué)第一附屬醫(yī)院口腔頜面外科;
【基金】：江西省科技廳自然科學(xué)基金重大項目(編號:20152ACB20019)
【分類號】：R739.8

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本文編號：1700943