本文選題：食管腫瘤　切入點(diǎn)：三維適形放射治療　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:比較胸中段食管癌三維適形放療(3D-CRT)和不同野調(diào)強(qiáng)放療(IMRT)劑量學(xué)差異。方法:病例自2015.2-2015.12首次在我院確診的15例胸中段食管癌患者,在模擬CT下定位,數(shù)據(jù)傳輸至Elekta計(jì)劃系統(tǒng)。對(duì)所有患者統(tǒng)一標(biāo)準(zhǔn)勾畫靶區(qū),分別制作3D-CRT、IMRT-5野、IMRT-7野、IMRT-9野4種放療計(jì)劃,采用單因素方差分析對(duì)4種放療劑量學(xué)行對(duì)比分析,顯著性差異檢驗(yàn)水平設(shè)為P0.05。結(jié)果:3DCRT和IMRT均能滿足靶區(qū)內(nèi)95%的等劑量曲線≥95%PTV體積的劑量學(xué)要求,3D-CRT計(jì)劃與所有IMRT靶區(qū)劑量學(xué)參數(shù)比較適形度指數(shù)(CI)、高劑量區(qū)體積(V105)、平均劑量(Dmean)均有顯著性差異(P0.05)。3D-CRT計(jì)劃與所有IMRT比較雙肺V20有顯著性差異(P0.05),雙肺低劑量區(qū)隨IMRT放射野數(shù)目增加而增大,高劑量區(qū)隨放射野數(shù)目增加而減小。3D-CRT計(jì)劃與IMRT比較脊髓受照射最大劑量(Dmax)有顯著性差異(P0.05),Dmax隨IMRT放射野數(shù)目的增加而降低;心臟比較無(wú)顯著性差異(P0.05)。3DCRT與IMRT比較機(jī)器跳數(shù)、有效治療時(shí)間均有顯著性差異(P0.05)。結(jié)論:3D-CRT與IMRT均可滿足胸中段食管癌放射治療要求,在靶區(qū)適形性和危及器官保護(hù)方面IMRT總體比較略有優(yōu)勢(shì),而3D-CRT減少了機(jī)器跳數(shù),縮短了單次治療時(shí)間,可在治療中獲益。
[Abstract]:Objective: to compare the dosimetry difference between 3D-CRT and IMRTT for middle thoracic esophageal carcinoma. Methods: 15 patients with middle thoracic esophageal carcinoma diagnosed in our hospital from May 2 to December 2015 were located under simulated CT. The data were transmitted to the Elekta planning system. The 3D-CRTRT IMRT-5 field IMRT-7 field IMRT-9 field four radiotherapy plans were made for all patients. The single factor variance analysis was used to compare the four radiotherapy dosimetry. Results the dosimetric requirements of 95% isodose curve 鈮，

本文編號(hào)：1696727