本文選題：血栓彈力圖　切入點：凝血功能　出處：《中國輸血雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的探討乳腺癌患者血栓彈力圖(TEG)各參數(shù)與常規(guī)凝血試驗指標的相關(guān)性,評價2種方法在檢測乳腺癌患者凝血功能中的作用。方法選取2014年在本院接受治療的270例女性乳腺癌患者作為觀察組,乳腺良性疾病患者210例作為對照組,2組均進行TEG與常規(guī)凝血試驗,將TEG檢測的各參數(shù)結(jié)果與凝血四項和血小板計數(shù)結(jié)果進行相關(guān)性分析,并評價TEG與常規(guī)凝血試驗指標對診斷乳腺癌患者高凝狀態(tài)的靈敏度和特異度。結(jié)果與乳腺良性疾病患者相比,乳腺癌患者PT(10.61±0.83)s vs(11.02±0.91)s和APTT(30.37±4.60)s vs(32.70±5.07)s,明顯縮短;FIB(2.75±0.55)g/L vs(2.50±0.47)g/L及Plt(250.33±65.34)×109L-1vs(233.74±51.83)×109L-1明顯升高,P均0.05;乳腺癌組R值(3.69±0.92)min vs(4.30±1.00)min和K值(1.47±0.50)min vs(1.70±0.39)min明顯縮短,Angle角(69.54±5.38)deg vs(66.55±4.37)deg、MA值(64.29±4.37)mm vs(62.24±3.58)mm和CI值(2.39±1.35)vs(1.42±1.18)明顯增大,P均0.05,表明患者存在血液高凝狀態(tài)。R值與活化部分凝血活酶時間(APTT)呈正相關(guān)性,與Plt呈負相關(guān)性(P0.05);K值與APTT、TT呈正相關(guān)性,與FIB、Plt呈負相關(guān)性(P0.05);Angle角與APTT、TT呈負相關(guān)性,與FIB、Plt呈正相關(guān)性(P0.05);MA與PT、APTT、TT呈負相關(guān)性,與FIB、Plt呈正相關(guān)性(P0.05);CI與APTT、TT呈負相關(guān),與FIB、Plt呈正相關(guān)性(P0.05)。TEG和常規(guī)凝血試驗指標對乳腺癌高凝患者的診斷靈敏度和特異性的一致性差。結(jié)論 TEG不僅能較全面地反映乳腺癌患者體內(nèi)的凝血狀況,而且與常規(guī)凝血試驗具有相關(guān)性,二者結(jié)合能夠更全面準確地反映患者的凝血狀況。
[Abstract]:Objective to investigate the correlation between the parameters of thromboelastogram (TEG) and the indexes of routine coagulation test in patients with breast cancer. To evaluate the role of two methods in detecting the coagulation function of breast cancer patients, 270 female breast cancer patients who were treated in our hospital in 2014 were selected as the observation group. Two hundred and ten patients with benign breast disease were treated with TEG and routine coagulation test. The correlation between the parameters of TEG and the four items of coagulation and platelet count was analyzed. The sensitivity and specificity of TEG and conventional coagulation test in the diagnosis of hypercoagulable state of breast cancer were evaluated. In breast cancer patients, PT(10.61 鹵0.83s vs(11.02 鹵0.91s and APTT(30.37 鹵4.60s vs(32.70 鹵5.07s significantly shortened the values of vs(2.50 鹵0.47g / L and Plt(250.33 鹵65.34 脳 10 9L -1 vs 233.74 鹵51.83) 脳 10 9L -1 (P < 0.05); in breast cancer patients, the R value was 3.69 鹵0.92min, vs(4.30 鹵1.00min, and K value 1.47 鹵0.50min vs(1.70 鹵0.39g / min, respectively. All of them were significantly shorter than those in breast cancer patients (69.54 鹵5.38deg vs(66.55 鹵4.37odegdegdegma 64.29 鹵4.37mm vs(62.24 鹵3.58mm and CI 2.39 鹵3.35vs1.1842 鹵1.1842). The value of state. R was positively correlated with activated partial thromboplastin time (APTT). There was a negative correlation between P0.05K and Plt, a negative correlation between P0.05T and APTTTT, a negative correlation between P0.05V angle and APTTTT, a positive correlation between P0.05T and Plt, a negative correlation between P0.05T and APTTTT, a negative correlation between P0.05CI and APTTTT with FIBPlt, a negative correlation between P0.05T and APTTTT, and a negative correlation between P0.05CI and APTTTT with FIBPlt. The diagnostic sensitivity and specificity of TEG in patients with breast cancer with hypercoagulability were poor. Conclusion TEG can not only reflect the coagulation status of breast cancer patients, but also can reflect the blood coagulation status of breast cancer patients. In addition, there is a correlation with the routine coagulation test, and the combination of the two can more comprehensively and accurately reflect the coagulation status of the patients.
【作者單位】： 鄭州大學附屬腫瘤醫(yī)院輸血科;
【分類號】：R737.9

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