本文選題：胃癌　切入點(diǎn)：癌旁組織　出處：《四川大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年01期 　論文類型：期刊論文

【摘要】：目的探討缺氧誘導(dǎo)因子-1α(HIF-1α)、葡萄糖轉(zhuǎn)運(yùn)蛋白-1(GLUT-1)及乳酸脫氫酶-5(LDH-5)在胃癌中表達(dá)的臨床病理意義。方法收集2014年3月至2015年9月貴州省人民醫(yī)院胃腸外科臨床資料完整的手術(shù)切除并經(jīng)病理確診為腺癌組織的胃癌標(biāo)本82例(實(shí)驗(yàn)組)。男42例,女40例。年齡19~77歲,平均64歲。Ⅰ~Ⅱ期44例,Ⅲ~Ⅳ期38例。同時(shí)取其胃癌旁組織作為對(duì)照組(82例)。采用免疫組化SP法檢測(cè)胃癌組織及其癌旁組織中HIF-1α、GLUT-1及LDH-5蛋白的表達(dá),分析其與臨床病理特征的關(guān)系。結(jié)果HIF-1α、GLUT-1及LDH-5在胃癌組織的表達(dá)率分別約為78.05%(64/82)、75.61%(62/82)及68.29%(56/82),與癌旁組織的表達(dá)率比較,其差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。胃癌組織中HIF-1α、GLUT-1及LDH-5的陽(yáng)性表達(dá)率與淋巴結(jié)轉(zhuǎn)移、腫瘤分化程度和病理分期有相關(guān)性(P均0.05);胃癌中HIF-1α、GLUT-1和LDH-5的表達(dá)兩兩之間呈正相關(guān)(P0.05)。結(jié)論 HIF-1α、GLUT-1及LDH-5在胃癌組織高度表達(dá)且與部分臨床病理特征有關(guān),或可考慮作為胃癌的診斷、治療及預(yù)后的指標(biāo)。
[Abstract]:Objective to investigate the clinicopathological significance of the expression of hypoxia-inducible factor-1 偽 (HIF-1 偽), glucose transporter (GLUT-1) and lactate dehydrogenase (LDH-5) in gastric cancer. Methods from March 2014 to September 2015, the clinical data of gastrointestinal surgery in Guizhou Provincial people's Hospital were collected. Methods Eighty-two gastric cancer specimens were surgically resected and pathologically diagnosed as adenocarcinoma (experimental group, n = 42, male, n = 42). There were 40 females aged 19 to 77 years, with an average age of 64 years. 44 cases of stage 鈪，

本文編號(hào)：1560010