本文關(guān)鍵詞： 臍帶間充質(zhì)干細胞 放射性肺纖維化 細胞治療　出處：《第三軍醫(yī)大學學報》2017年10期 　論文類型：期刊論文

【摘要】：目的觀察臨床級臍帶間充質(zhì)干細胞(clinical grade umbilical cord mesenchymal stem cell,UC-MSC)治療放射性肺纖維化(radiation-induced pulmonary fibrosis,RPF)的安全性和有效性。方法從2014年1月至2016年6月共入組8例RPF患者,其中2例乳腺癌,6例肺癌。通過支氣管鏡對RPF病灶部位灌洗后單次注入臍帶間充質(zhì)干細胞(1×10~6/kg),觀察治療前及治療后第3天、3個月、6個月的臨床癥狀、血液指標和圣喬治呼吸問卷(St George’s respiratory questionnaire,SGRQ)、6 min步行距離(six-minute walk distance,6MWD)、肺功能指標、相關(guān)炎癥因子、CT肺密度的變化情況。結(jié)果 8例患者均能耐受UC-MSC治療,6例患者自覺氣促、咳嗽等癥狀有所好轉(zhuǎn),圣喬治呼吸問卷評分有差異(P0.05),血常規(guī)、C反應蛋白、肝腎功指標治療前后無明顯變化,轉(zhuǎn)化生長因子-β1(transforming growth factor-β1,TGF-β1)在治療后有下降趨勢,但差異無統(tǒng)計學意義(P0.05),CT肺密度自身治療前后比較有下降。結(jié)論 UC-MSC治療RPF對患者的肝腎等主要臟器無損害,且能夠減輕患者的臨床癥狀和降低肺纖維化密度,但其確切的治療效果及機制需更加嚴謹?shù)难芯窟M一步證實。
[Abstract]:Objective to observe clinical grade umbilical cord mesenchymal stem cell of umbilical cord mesenchymal stem cells. UC-MSCI was used to treat radiation-induced pulmonary fibrosis. Methods from January 2014 to June 2016, 8 patients with RPF were enrolled, 2 of them were breast cancer. Six cases of lung cancer were treated with bronchoscopy. Umbilical cord mesenchymal stem cells were injected with 1 脳 10 ~ (-6) / kg ~ (-1) 路kg ~ (-1) of umbilical cord mesenchymal stem cells by bronchoscopy. Before treatment and 3 days after treatment, 3 months after treatment were observed. Six months of clinical symptoms, blood indicators and St George's respiratory questionnaire questionnaire (St George's respiratory questionnaire SGRQ). 6 min walking distance from six-minute walk distension to 6MW DX, pulmonary function index, and related inflammatory factors. Results the changes of lung density in CT were all able to tolerate UC-MSC treatment in 6 patients with spontaneous shortness of breath and cough. The score of St. George's Respiratory questionnaire was significantly different (P 0.05). There was no significant change in serum C-reactive protein and liver and kidney function before and after treatment. Transforming growth factor- 尾 _ 1 was transformed into growth factor- 尾 _ 1. TGF- 尾 1) decreased after treatment, but the difference was not statistically significant (P 0.05). Conclusion UC-MSC can not damage the main organs such as liver and kidney, and can alleviate the clinical symptoms and reduce the density of pulmonary fibrosis. But its exact therapeutic effect and mechanism need to be further confirmed by more rigorous research.
【作者單位】： 第三軍醫(yī)大學西南醫(yī)院呼吸內(nèi)科;第三軍醫(yī)大學西南醫(yī)院老年科;
【基金】：中國科學院戰(zhàn)略性先導專項項目(XDA 01030000)~~
【分類號】：R730.55
【正文快照】： 放射性肺損傷是在對胸部惡性腫瘤(肺癌、乳腺南醫(yī)院和新橋醫(yī)院放療中心篩選放療病人1 829例,癌、食管癌等)進行放射治療時引起的肺組織損傷。根據(jù)納入標準共入組8例RPF患者,患者具體篩選流根據(jù)放射性肺損傷發(fā)生在放療后的時間不同分為:放程圖見圖1,其中2例乳腺癌,6例肺癌,年齡

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