【摘要】：目的探討鋁電解職業(yè)人群認(rèn)知功能減退和周圍血全基因組甲基化改變之間的關(guān)系。方法采用橫斷面調(diào)查方法,以366名從事鋁電解作業(yè)10年以上的工人為鋁接觸組,以102名面粉廠工人為對(duì)照組。2組人群均采用簡(jiǎn)易精神狀態(tài)量表(MMSE)評(píng)價(jià)認(rèn)知功能,采集周圍血檢測(cè)血清鋁水平和全基因組甲基化率。鋁接觸組人群根據(jù)是否檢出輕度認(rèn)知功能障礙(MCI)分為MCI和非MCI亞組。結(jié)果與對(duì)照組比較,鋁接觸組人群血清鋁水平較高[中位數(shù)(M):48.99 vs 29.17μg/L,P0.01],MMSE總分較低[(27.78±1.38)vs(29.10±1.77)分,P0.01],MCI檢出率較高(11.75%vs 2.94%,P0.01),全基因組甲基化率較低[M:15.05%vs 17.01%,P0.01]。鋁接觸組人群MMSE總分和全基因組甲基化率均隨血清鋁水平增加而下降(P0.05)。鋁接觸組人群MCI亞組全基因組甲基化率低于非MCI亞組[M:15.53%vs 17.54%,P0.05]。多元線性逐步回歸分析結(jié)果顯示,鋁電解職業(yè)人群MMSE總分與血清鋁水平呈負(fù)相關(guān)(P0.05),與全基因組甲基化水平呈正相關(guān)(P0.01)。結(jié)論長(zhǎng)期接觸鋁可以導(dǎo)致職業(yè)人群MCI,其認(rèn)知水平和鋁接觸水平及周圍血全基因組甲基化水平均有關(guān)聯(lián)。
[Abstract]:Objective to investigate the relationship between cognitive impairment and genomic methylation of peripheral blood in aluminum electrolysis workers. Methods A cross-sectional survey was conducted. 366 workers who had been engaged in aluminum electrolysis for more than 10 years were selected as the aluminum exposure group and 102 flour mill workers as the control group. The cognitive function was evaluated by simple mental state scale (MMSE) in both groups. Peripheral blood samples were collected to detect serum aluminum level and genomic methylation rate. Aluminum exposure group was divided into MCI subgroup and non-MCI subgroup according to whether mild cognitive impairment (MCI) was detected. Results compared with the control group, the serum Al level in the aluminum exposure group was higher [median (M): 48.99 vs 29.17 渭 g / L P0.01], and the total MMSE score was lower [(27.78 鹵1.38) vs (29.10 鹵1.77), P 0.01]. The detection rate of MCI was higher (11.75%vs 2.94) and the whole genome methylation rate was lower [M:15.05%vs 17.01]. The total MMSE score and total genomic methylation rate of aluminum exposure group decreased with the increase of serum aluminum level (P0.05). The total genomic methylation rate of MCI subgroup in aluminum exposure group was lower than that in non MCI subgroup [M:15.53%vs 17.54% P0.05]. Multiple linear stepwise regression analysis showed that the total score of MMSE in aluminum electrolysis workers was negatively correlated with serum aluminum level (P0.05) and positively correlated with the whole genome methylation level (P0.01). Conclusion Long-term exposure to aluminum can lead to the association of MCI, cognitive level with aluminum exposure level and the whole genome methylation level of peripheral blood.
【作者單位】： 山西醫(yī)科大學(xué)第一臨床醫(yī)學(xué)院老年病科;山西醫(yī)科大學(xué)公共衛(wèi)生學(xué)院勞動(dòng)衛(wèi)生教研室;
【基金】：國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目(81430078)
【分類號(hào)】：R135

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本文編號(hào)：2406485