【摘要】：研究苦瓜多糖對一次性力竭運動后小鼠疲勞緩解及氧化損傷影響。以醇沉水提法制備的苦瓜多糖灌胃小鼠21 d后,采用力竭游泳試驗,測定小鼠力竭游泳時間,血清乳酸,乳酸脫氫酶及尿素氮,肝肌糖原及組織(心肌、肝臟)中谷胱甘肽過氧化物酶(glutathione peroxidase,GPX)與超氧化物歧化酶(superoxide dismutase,SOD)活力、丙二醛(malondialdehyde,MDA)含量。同力竭對照小鼠比較,苦瓜多糖能延長小鼠負重游泳時間,提高肝臟及肌肉糖原水平,減少運動后血乳酸,尿素氮的堆積,提高乳酸脫氫酶活性。此外,還可提高心臟及肝臟中SOD及GPX活性,降低MDA水平。結果表明苦瓜多糖具有顯著的抗疲勞功效,可減輕大強度運動后自由基造成的氧化損傷,促進機體功能恢復。
[Abstract]:The effects of Momordica charantia polysaccharides on fatigue relief and oxidative damage in mice after exhaustive exercise were studied. After the mice were perfused with polysaccharides from Momordica charantia by alcohol precipitation for 21 days, the exhaustive swimming time, serum lactic acid, lactate dehydrogenase and urea nitrogen, glycogen in liver muscle and tissue (myocardium) were determined by exhaustive swimming test. The activity of glutathione peroxidase (glutathione peroxidase,GPX) and superoxide dismutase (superoxide dismutase,SOD) and the content of malondialdehyde (malondialdehyde,MDA) in liver. Compared with the exhausted control mice, Momordica charantia polysaccharide could prolong the swimming time, increase the glycogen level of liver and muscle, reduce the accumulation of blood lactic acid and urea nitrogen, and increase the activity of lactate dehydrogenase. In addition, it also increased the activity of SOD and GPX in heart and liver, and decreased the level of MDA. The results showed that Momordica charantia polysaccharide had obvious anti-fatigue effect, which could reduce the oxidative damage caused by free radicals and promote the recovery of body function.
【作者單位】： 河南科技學院;
【分類號】：R151

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